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Publikováno v:
Genes & Diseases. 10:542-553
Periodontitis is an oral chronic inflammatory disease. Inhibiting tissue destruction and promoting tissue regeneration are important means for the treatment of periodontitis. Metformin not only has hypoglycemic effect but also has anti-inflammatory e
Publikováno v:
J Biomol Struct Dyn
Modulation of proteasome function by pharmacological interventions and molecular biology tools is an active area of research in cancer biology and neurodegenerative diseases. Curcumin (diferuloylmethane) is a naturally occurring polyphenol that affec
Publikováno v:
Antioxidantsredox signaling. 37(7-9)
SIGNIFICANCE Reactive oxygen species (ROS) contribute to multiple aspects of peripheral nervous system (PNS) biology ranging from physiological processes (e.g. axonal outgrowth and regeneration), to pathophysiology (e.g. nerve degeneration). Although
Publikováno v:
Aquaculture and Fisheries. 8:18-25
In this paper, we studied the structure, expression and function of black carp insulin gene. The complete Mylopharyngodon piceus insulin (Mp-Ins) gene is 1,965 bp long and includes a 1,499 bp 5ʹ-untranslated region (UTR), a 139 bp 3′-UTR with a po
Autor:
Colin G. Nichols, Robert C. Tryon, Maria S. Remedi, Nathaniel W. York, Jennifer Ikle, Soma S. Singareddy
Publikováno v:
Islets. 14:200-209
KATP channel gain- (GOF) and loss-of-function (LOF) mutations in SUR1 or Kir6.2 underlie human neonatal diabetes mellitus (NDM) and congenital hyperinsulinism (CHI), respectively. Genetically modified mice with transgenic overexpression of GOF mutati
Autor:
Jun-ichi Ohkubo, Thi Nga Nguyen, Hideaki Suzuki, Yasuhiro Yoshida, Takuro Kitamura, Tetsuro Wakasugi
Publikováno v:
Auris Nasus Larynx. 49:964-972
Objective Transglutaminase (TGM)2 and peroxisome proliferator-activated receptor (PPAR)γ are thought to participate in the pathogenesis of nasal polyp formation in cystic fibrosis (CF). We herein investigated expressions of cystic fibrosis transmemb
Autor:
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Publikováno v:
Am J Respir Cell Mol Biol
RationalePulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Facto
Autor:
Xiaofeng Xu, Hua Han
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 37:779-791
Background: Both microRNA (miR)-205 and GATA Binding Protein 3 (GATA3) were involved in cervical cancer (CC), yet their correlation remained poorly understood. The authors' study aimed to unveil their correlation in CC. Materials and Methods: Clinica
Publikováno v:
Current Molecular Medicine. 22:722-734
Abstract: Microglia are immune cells found in the central nervous system (CNS) involved in infection combat and cellular debris clean. These glial cells are involved in synaptogenesis during brain development by their interactions with neurons and ot
Autor:
Sibasish Mohanty, Pallavi Mohapatra, Omprakash Shriwas, Shamima Azma Ansari, Manashi Priyadarshini, Swatismita Priyadarsini, Rachna Rath, Mahesh Sultania, Saroj Kumar Das Majumdar, Rajeeb Kumar Swain, Rupesh Dash
Publikováno v:
Oncogene. 41:4929-4940
Cisplatin, 5FU and docetaxel (TPF) are the most common chemotherapy regimen used for advanced OSCC. However, many cancer patients experience relapse, continued tumor growth, and spread due to drug resistance, which leads to treatment failure and meta