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Publikováno v:
Developmental Biology. 498:35-48
Fibroblasts play an important role in maintaining tissue integrity by secreting components of the extracellular matrix and initiating response to injury. Although the function of fibroblasts has been extensively studied in adults, the embryonic origi
Autor:
Jane C Fenelon, Alistair R. Evans, Michael Pyne, Stephen D. Johnston, Neal Anthwal, Abigail S. Tucker, Abbie Bennetts, Marilyn B. Renfree
Publikováno v:
Developmental Biology. 495:8-18
In the short-beaked echidna, Tachyglossus aculeatus, after an initial period of in utero development, the egg is laid in the pouch and incubated for 10 days. During this time, the fetuses develop an egg tooth and caruncle to help them hatch. However,
Publikováno v:
Aquaculture and Fisheries. 8:18-25
In this paper, we studied the structure, expression and function of black carp insulin gene. The complete Mylopharyngodon piceus insulin (Mp-Ins) gene is 1,965 bp long and includes a 1,499 bp 5ʹ-untranslated region (UTR), a 139 bp 3′-UTR with a po
Autor:
Colin G. Nichols, Robert C. Tryon, Maria S. Remedi, Nathaniel W. York, Jennifer Ikle, Soma S. Singareddy
Publikováno v:
Islets. 14:200-209
KATP channel gain- (GOF) and loss-of-function (LOF) mutations in SUR1 or Kir6.2 underlie human neonatal diabetes mellitus (NDM) and congenital hyperinsulinism (CHI), respectively. Genetically modified mice with transgenic overexpression of GOF mutati
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:2189-2201
Background: Eryngium is a genus flowering plant in the Umbelliferae family, having pharmacological properties, such as anti-inflammatory and anti-diabetic. Given the nature of melanoma and breast cancers in recent years and the fact that the anti-can
Autor:
Roberto Docampo, Anibal E. Vercesi
Publikováno v:
Antioxidants & Redox Signaling. 36:969-983
Significance Millions of people are infected with trypanosomatids and new therapeutic approaches are needed. Trypanosomatids possess one mitochondrion per cell, and its study has led to discoveries of general biological interest. These mitochondria,
Autor:
Samuel Long, Brian Berkemeier
Publikováno v:
Methods. 201:49-64
Sensitive detection of viral nucleic acids is critically important for diagnosis and monitoring of the progression of infectious diseases such as those caused by SARS-CoV2, HIV-1, and other viruses. In HIV-1 infection cases, assessing the efficacy of
Autor:
Nahla Gamal, Abdel-Rahman N. Zekri, Nadia El-Guendy, Reem Mebed, Nahla Shehata, Yasser B.M. Ali, Salwa Sabet
Publikováno v:
Current Molecular Medicine. 22:374-383
Background: Bevacizumab (Bev) resistance is hypothesized to be overcome by combining inhibitors of other signalling pathways. Objective: We aimed to study the effect of combining Bev with knocked down β-catenin (Bev-β-cat-siRNA) on the expression o
Publikováno v:
Molecular Therapy. 30:2078-2091
Zika virus (ZIKV), a flavivirus associated with neurological disorders, constitutes a global health threat. During pregnancy, ZIKV traverses the placenta and causes congenital disease such as microcephaly and Guillain-Barre syndrome in newborns. To d
Autor:
Anouck Becker, Valentina Galata, Georges Pierre Schmartz, Eckart Meese, Jörn Walter, Andreas Keller, Sascha Tierling, Jacqueline Weiland, Laura Gröger, Andreas Schwiertz, Nadja Grammes, Marcus M. Unger, Gudrun Wagenpfeil, Hannah Philippeit, Nicole Ludwig, Klaus Faßbender, Jörg Spiegel
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:274-287
The composition of the gut microbiome is linked to multiple diseases, including Parkinson’s disease (PD). Bacteria producing short-chain fatty acids (SCFAs) and fecal SCFA concentrations are reduced in PD. SCFAs exert various beneficial functions i