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Introduction: The histone methyltransferase EZH2 is the catalytic subunit of the PRC2 complex involved in H3K27 trimethylation. Aberrant PRC2 activity has been reported in several cancers and EZH2 overexpression has been associated with poor outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb72ab8d83cffa63437b8c6cc23f2f36
Autor:
Francesco Spallotta, Carlo Gaetano, Antonello Mai, Andreas M. Zeiher, Fabio Martelli, Sergio Valente, Chiara Cencioni
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are availab
Lysine demethylase 1 (LSD1) plays an important role in mediating the expression of genes involved in cancer and non-cancer diseases such as viral infections, cardiovascular and neurodegenerative disorders. It is involved in a number of processes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b34fa3d359d482f0990303e31d1946
http://hdl.handle.net/11573/870518
http://hdl.handle.net/11573/870518
Publikováno v:
Expert opinion on therapeutic patents. 25(1)
Since 2000 sirtuins (SIRT1-7) have gained growing attention for their connections with many biological processes such as cellular metabolism regulation, neuroprotection, apoptosis, inflammation, and cancer progression. In particular, SIRT1 has been t
Autor:
Antonello Mai, Sergio Valente
Publikováno v:
Expert opinion on therapeutic patents. 24(4)
Histone deacetylases (HDACs) play an important role in mediating the expression of genes involved in cancer and non-cancer diseases. Overexpression of these enzymes has been shown in several types of cancer and some enzyme isoforms were described as
Autor:
Marta Valenza, Sergio Valente, Vanita Chopra, Luisa Quinti, Michele M. Maxwell, Dante Rotili, Aleksey G. Kazantsev, Antonello Mai, Lucia Altucci, Gianluigi Franci, Sarah Meade, Elena Cattaneo, Steven M. Hersch, Allison M. Amore
Publikováno v:
PLoS Currents. 2:RRN1172
The family of histone deacetylases (HDACs) has recently emerged as important drug targets for treatment of slow progressive neurodegenerative disorders, including Huntingtons disease (HD). Broad pharmaceutical inhibition of HDACs has shown neuroprote