Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sergio Valente"'
Autor:
Clemens Steegborn, Chunbo He, Fang Yu, Antonello Mai, Kuldeep S. Attri, Sarika Chaudhary, Eric Verdin, Ping Lan, Tuo Hu, Sergio Valente, Surendra K. Shukla, Audrey J. Lazenby, Enza Vernucci, Ravi Thakur, David A. Tuveson, Divya Murthy, Xiao Fu, Nicholas J Mullen, Dante Rotili, Ryan J. King, Pankaj Singh, Dezhen Wang, Kamiya Mehla, Marco Tafani, Scott E. Mulder, Robin High, Kanupriya Jha, Johan Auwerx, Nina V. Chaika, Kasturi Siddhanta, Camila G. Pacheco
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarci
Publikováno v:
Journal of Medicinal Chemistry
Epigenetics is nowadays a well-accepted area of research. In the last years, tremendous progress was made regarding molecules targeting EZH2, directly or indirectly. Recently tazemetostat hit the market after FDA-approval for the treatment of lymphom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69155e75b57af29a69fbd97848202bc2
http://hdl.handle.net/11588/865398
http://hdl.handle.net/11588/865398
Autor:
Daniel I. Benjamin, Alessandro Aliverti, Antonello Mai, Sergio Valente, Biagina Marrocco, Daniel K. Nomura, Andrea Mattevi, Simone Nenci, Valentina Piano
Publikováno v:
ACS Chemical Biology. 10:2589-2597
Dysregulated ether lipid metabolism is an important hallmark of cancer cells. Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers ke
Publikováno v:
Expert Opinion on Drug Discovery. 10:599-613
Histone deacetylases (HDACs) are key players in the mediation of gene expression for both cancerous and noncancerous malignancies. Overexpression of these enzymes has been demonstrated in numerous types of cancer with some enzyme isoforms also involv
Introduction: The histone methyltransferase EZH2 is the catalytic subunit of the PRC2 complex involved in H3K27 trimethylation. Aberrant PRC2 activity has been reported in several cancers and EZH2 overexpression has been associated with poor outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb72ab8d83cffa63437b8c6cc23f2f36
Autor:
Irene Bozzoni, Stefania Straino, Claudia Colussi, Antonella Farsetti, Matteo Vecellio, Francesco Spallotta, Jessica Rosati, Sergio Valente, Maurizio C. Capogrossi, Alfredo Pontecorvi, Antonello Mai, Silvia Tardivo, Julie Martone, Carlo Gaetano, Simona Nanni
Publikováno v:
The Journal of biological chemistry
288 (2013): 22915–22929. doi:10.1074/jbc.M113.484337
info:cnr-pdr/source/autori:Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7/titolo:Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia/doi:10.1074%2Fjbc.M113.484337/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:22915/pagina_a:22929/intervallo_pagine:22915–22929/volume:288
288 (2013): 22915–22929. doi:10.1074/jbc.M113.484337
info:cnr-pdr/source/autori:Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7/titolo:Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia/doi:10.1074%2Fjbc.M113.484337/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:22915/pagina_a:22929/intervallo_pagine:22915–22929/volume:288
Histone deacetylase inhibitors (DIs) are promising drugs for the treatment of several pathologies including ischemic and failing heart where they demonstrated efficacy. However, adverse side effects and cardiotoxicity have also been reported. Remarka
Autor:
Paolo Mellini, Donatella Del Bufalo, Sébastien Moniot, Lucia Polletta, Clemens Steegborn, Marco Tafani, Ilaria Carnevale, Roberta Budriesi, Maria Tardugno, Lucia Altucci, Chiara Gabellini, Sandra Atlante, Daniela Trisciuoglio, Antonello Mai, Vincenzo Carafa, Angela Nebbioso, Serena Saladini, Sergio Valente, Francesco Spallotta, Clemens Zwergel, Chiara Cencioni, Carlo Gaetano
Publikováno v:
Journal of medicinal chemistry (2016).
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
Modulators of sirtuins are considered promising therapeutic targets for the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases. Here we prepared new 1,4-dihydropyridines (DHPs) bearing changes at the C2/C6, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4bbdf098839e19177d1bd2f68f8889
http://hdl.handle.net/11573/870523
http://hdl.handle.net/11573/870523
Lysine demethylase 1 (LSD1) plays an important role in mediating the expression of genes involved in cancer and non-cancer diseases such as viral infections, cardiovascular and neurodegenerative disorders. It is involved in a number of processes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b34fa3d359d482f0990303e31d1946
http://hdl.handle.net/11573/870518
http://hdl.handle.net/11573/870518
Autor:
Roberto Cirilli, Maria Tardugno, Aristotele Karytinos, Saverio Minucci, Antonello Mai, Sergio Valente, Simona Pilotto, Claudia Binda, Mauro Romanenghi, Federico Forneris, Dale E. Edmondson, Andrea Mattevi, Giuseppe Ciossani, Oronza A. Botrugno
Publikováno v:
Journal of the American Chemical Society. 132:6827-6833
LSD1 and LSD2 histone demethylases are implicated in a number of physiological and pathological processes, ranging from tumorigenesis to herpes virus infection. A comprehensive structural, biochemical, and cellular study is presented here to probe th
Autor:
Antonello Mai, Jorge Domínguez-Andrés, Elena Puerta, M.M. Erburu, Sergio Valente, Rosa M. Tordera, Takayoshi Suzuki, Elena Beltran, I. Muñoz-Cobo
Changes in histone acetylation could contribute to the pathogenesis of depression and antidepressant therapy. Using the chronic social defeat stress (CSDS) model of depression and different antidepressant treatments we studied the regulation of histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cadd1d6ed1bce716c27a14ea96385a
http://hdl.handle.net/11573/884185
http://hdl.handle.net/11573/884185