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Autor:
Morie A. Gertz, Yi Lisa Hwa, Stephen J. Russell, David Dingli, Taxiarchis Kourelis, Wilson I. Gonsalves, Shaji Kumar, Eli Muchtar, Robert A. Kyle, Rahma Warsame, Francis K. Buadi, Mustaqeem A. Siddiqui, Nelson Leung, Prashant Kapoor, Suzanne R. Hayman, Amie Fonder, Moritz Binder, S. Vincent Rajkumar, Miriam Hobbs, Yi Lin, Martha Q. Lacy, Bharat Nandakumar, Angela Dispenzieri
Publikováno v:
Leukemia. 36:801-808
Background: There has been a steady improvement in the survival of patients with multiple myeloma (MM) due to better understanding of the pathophysiology, use of novel agents, and risk-adapted therapy. These improvements were largely observed in clin
Autor:
Brian S. Gloss, Kavitha Gowrishankar, Piers Blombery, Raymond H. Y. Louie, Kenneth P. Micklethwaite, Emily Blyth, Fritz J. Sedlazeck, Janine Street, David Gottlieb, Matthew MacKay, Christopher E. Mason, David Bishop, Leili Moezzi, Gaurav Sutrave, Curtis Cai, Ziduo Li, Leighton Clancy, Fabio Luciani, Jonathan Foox, Melanie A Mach
Publikováno v:
Blood. 138:1391-1405
We performed a phase 1 clinical trial to evaluate outcomes in patients receiving donor-derived CD19-specific chimeric antigen receptor (CAR) T cells for B-cell malignancy that relapsed or persisted after matched related allogeneic hemopoietic stem ce
Autor:
Kazuki Furuhashi, Katsuhiro Yoshimura, Masato Karayama, Noriyuki Enomoto, Naoki Inui, Hironao Hozumi, Takafumi Suda, Yutaro Nakamura, Yuzo Suzuki, Yusuke Inoue, Tomoyuki Fujisawa
Publikováno v:
Journal of Immunotherapy. 45:125-131
The nutritional status has the potential to affect cancer immunity. We evaluated the relationship between the nutritional status and the efficacy of nivolumab in patients with non-small cell lung cancer (NSCLC). This study was a post hoc analysis of
Autor:
Zeinab Albadry M. Zahran, Khalid Muhammad, Alaa Rashad, Zeinab A Abd Elhameed, Yasir Waheed, Salah M. Khallaf, Gaber El-Saber Batiha, Amal Rayan, Dalia O. Mohamed, Hanaa Nafady-Hego, Helal F Hetta, Asmaa M Zahran
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research
Journal of Immunology Research
Background and Aim. Myeloid-derived suppressor cells (MDSCs) contribute to the process of malignant transformation and tumor progression through immuno- and nonimmunosuppressive mechanisms. The current study is aimed at providing the predictive and p
Autor:
Stephanie Humblet-Baron, Stanislas Goriely, Pieter Pannus, B. Willems, Leo Heyndrickx, Sophie Servais, Kevin K. Ariën, Lorenzo Canti, Grégory Ehx, Adrian Liston, Johan Michiels, Aurélie Henry, Yves Beguin, Maria E Goossens, Arnaud Marchant, Frédéric Baron, Evelyne Willems, Isabelle Desombere, Julika Neumann, Laurence Seidel
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-12 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology, 14 (1
Journal of Hematology & Oncology
Journal of Hematology & Oncology, 14 (1
Background Factors affecting response to SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients remain to be elucidated. Methods Forty allo-HCT recipients were included in a study of immunization with BNT1
Autor:
Xiangkai Zhang, Shuli Liu, Jiong Deng, Yong Han, Liu Liu, Yang Wang, Shengming Xu, Zhiyuan Zhang, Weimin Ye
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor with poor clinical outcomes due to recurrence, metastasis, and treatment resistance. Cancer stem cells (CSCs), a small population among tumor cells, are proposed to be respons
Publikováno v:
Journal of Interferon & Cytokine Research. 41:375-384
Inflammatory cytokines has been of great interest in the field of colorectal cancer (CRC) tumor immunology in recent years. As an anti-inflammatory interleukin (IL), IL-38 may contribute to the ear...
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Colorectal tumorigenesis is a heterogeneous disease driven by multiple genetic and epigenetic alterations. F-box and WD repeat domain containing 11 (FBXW11) is a member of the F-box protein family that regulates the ubiquitination of key factors asso
Autor:
John C. Byrd, Deborah M. Stephens
Publikováno v:
Blood
Bruton tyrosine kinase inhibitors (BTKi) have significantly changed the treatment landscape for patients with B-cell malignancies, including chronic lymphocytic leukemia, Waldenstrom macroglobulinemia, mantle cell lymphoma, and marginal zone lymphoma
Autor:
Suzanne Krishfield, Elena N Cravens, Suruchi A Ramanujan, Vaishali R. Moulton, Vasileios C. Kyttaris
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective Autoimmune diseases affect women disproportionately more than men. Estrogen is implicated in immune cell dysfunction, yet its precise molecular roles are not fully known. We recently identified new roles for serine/arginine‐rich splicing