Zobrazeno 1 - 10
of 45 253
pro vyhledávání: ''
Publikováno v:
Seminars in Cancer Biology. 85:123-154
The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway involved in cell proliferation and survival. The three-layered MAPK signaling cascade is initiated upon RTK and RAS activation. Three RAF isoforms ARAF, BRAF and CRAF, and their d
Autor:
Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Bishnu Prasad Behera, Kewal Kumar Mahapatra, Shankargouda Patil, Amruta Singh, Rohan Dhiman, Srimanta Patra, Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra
Publikováno v:
Seminars in Cancer Biology. 83:399-412
Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-
Autor:
Sarah R. Amend, Emma U. Hammarlund, Robert Axelrod, Kenneth J. Pienta, Joel S. Brown, Robert H. Austin
Publikováno v:
Pienta, K J, Hammarlund, E U, Austin, R H, Axelrod, R, Brown, J S & Amend, S R 2022, ' Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy ', Seminars in Cancer Biology, vol. 81, pp. 145-159 . https://doi.org/10.1016/j.semcancer.2020.11.016
Unusually large cancer cells with abnormal nuclei have been documented in the cancer literature since 1858. For more than 100 years, they have been generally disregarded as irreversibly senescent or dying cells, too morphologically misshapen and chro
Publikováno v:
Semin Cancer Biol
The completion-of-tumor hypothesis involved in the dynamic interplay between the initiating oncogenic event and progression is essential to better recognize the foundational framework of tumors. Here we review and extend the gametogenesis-related hyp
Thrombus formation is dependent on the interaction of platelets, leukocytes and endothelial cells as well as proteins of the coagulation cascade. This interaction is tightly controlled by phospho-regulated pathways involving protein kinase CK2. A gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a1e8f015cf6edcffd7aa22cd6d13c
Publikováno v:
Seminars in Cell & Developmental Biology. 124:134-144
Malignancies of hepatocellular carcinoma (HCC) are rapidly spreading and commonly fatal. Like most cancers, the gene expression patterns in HCC vary significantly from patient to patient. Moreover, the expression networks during HCC progression are l
Autor:
Nivetha Sarah Ebenezer, Jawed A. Siddiqui, Mohd W. Nasser, Imayavaramban Lakshmanan, Ravi Salgia, Surinder K. Batra, Shailendra Kumar Maurya, Parvez Khan
Publikováno v:
Semin Cell Dev Biol
The process of cancer initiation and development is a dynamic and complex mechanism involving multiple genetic and non-genetic variations. With the development of high throughput techniques like next-generation sequencing, the field of cancer biology
Publikováno v:
Antioxidants & Redox Signaling. 36:608-630
Significance: Diabetic heart disease (DHD) is the primary cause of mortality in people with diabetes. A significant contributor to the development of DHD is the disruption of redox balance due to r...
Autor:
Pooria Fallah, Huling Lyu, Dan Burch, Deborah Foyle, Thomas G.H. Diekwisch, Xianghong Luan, Xiaofeng Zhou, Mirali Pandya
Publikováno v:
Semin Cell Dev Biol
Periodontal disease is an inflammatory reaction of the periodontal tissues to oral pathogens. In the present review we discuss the intricate effects of a regulatory network of gene expression modulators, microRNAs (miRNAs), as they affect periodontal
Publikováno v:
Seminars in Cell & Developmental Biology. 124:127-133
Hepatocellular carcinoma (HCC) is the third prominent cause of cancer mortality, with increasing prevalence and poor survival worldwide. Being diagnosed at an advanced stage, HCC frequently results in poor prognosis, treatment failure, and recurrence