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MicroRNAs (miRNAs) crucially modulate fundamental biologic processes such as angiogenesis. In the present study, we focused on the molecular function of miRNA-370-3p (miR-370) in regulating the angiogenic activity of endothelial cells (ECs). Transfec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aa23e93d80c91eef5d69c1fda31721
Autor:
David C.S. Huang, Amber E. Alsop, Wai Shan Yuen, Grant Dewson, Khatira Anwari, Ruth M. Kluck, Nicholas A. Smith, John L. Carroll, Brian J. Smith, Sweta Iyer
Publikováno v:
ResearcherID
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2–α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a389d82c2bc8601be7026532200662c6
Publikováno v:
J Invest Dermatol
The Ca(2+)-sensing receptor (CaSR) drives essential Ca(2+) and E-cadherin-mediated processes in the epidermis, including differentiation (Komuves et al., 2002), cell-to-cell adhesion (Tu et al., 2008) and epidermal barrier homeostasis in cells and yo
Publikováno v:
Journal of Investigative Dermatology. 141:2679-2689
Opsin-3 (OPN3) is a potential key regulator of human melanocyte melanogenesis. How OPN3-mediated regulation of melanocyte melanogenesis is triggered is largely unclear. TGFβ can inhibit the growth of human melanocytes and reduce melanin synthesis in
Publikováno v:
Journal of Investigative Dermatology. 141:2354-2368
Cutaneous squamous cell carcinomas (SCCs) are frequent heterogeneous tumors arising from sun-exposed regions of the skin and characterized by complex pathogenesis. HOPX is a member of the homeodomain-containing superfamily of proteins holding an atyp
Autor:
Wataru Morozumi, Yuki Iwata, Hideaki Hara, Masamitsu Shimazawa, Shinsuke Nakamura, Kota Aoshima, Satoshi Inagaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 2, Pp 211-221 (2021)
Trabecular meshwork (TM) regulates the intraocular pressure (IOP) through the control of aqueous humor outflow. Previous reports show that TM cells express 11 types of mechanosensitive molecules, including Piezo 1, which sense mechanical stimuli. How
Autor:
Xianying Xing, Bogi Andersen, Alexander A. Merleev, Jiaoling Chen, Lam C. Tsoi, Joseph Kirma, Mrinal K. Sarkar, Chang Zeng, Robert L. Modlin, Shuai Shao, William R. Swindell, Rachael Wasikowski, Olesya Plazyo, Allison C. Billi, Matteo Pellegrini, Feiyang Ma, Johann E. Gudjonsson, Nicole L. Ward, Jingru Sun, Yanyun Jiang, J. Michelle Kahlenberg, Ranjitha Uppala, Stephan Weidinger, Emanual Michael Maverakis, Bethany E. Perez White, Paul W. Harms, Gang Wang, John J. Voorhees
Publikováno v:
J Invest Dermatol
The Journal of investigative dermatology, vol 141, iss 10
The Journal of investigative dermatology, vol 141, iss 10
Many inflammatory skin diseases are characterized by altered epidermal differentiation. Whether this altered differentiation promotes inflammatory responses has been unknown. Here, we show that IRAK2, a member of the signaling complex downstream of I
Autor:
Ya-Yu Zhao, Chen-Chun Wang, Jia-Lu Ying, Xue Chen, Hong-Bo Jin, Cheng-Cheng Yang, Xin-Yao Yin, Yi-Chi Lu, Pan Du
Publikováno v:
Biochemical and Biophysical Research Communications. 568:103-109
At present, stem cell transplantation has a significant therapeutic effect on spinal cord injury (SCI), however, it is still challenging for the seed cells selection. In this study, in order to explore cells with wide neural repair potentials, we sel
Publikováno v:
J Invest Dermatol
Dermatomyositis (DM) is a rare, systemic autoimmune disease that most frequently affects the skin, muscles, and lungs. The inflammatory infiltrate in the skin has not been fully characterized, and, in this study, we took a single-cell, unbiased appro
Autor:
Ronald Hoffman, Manisha Kintali, Christoph Schaniel, Camelia Iancu-Rubin, Luena Papa, Mansour Djedaini, Marcia Meseck, Mahtab Zangui
Publikováno v:
Cytotherapy. 23:841-851
Background aims Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for a wide range of malignant and genetic disorders of the hematopoietic and immune systems. Umbilical cord blood (UCB) is a readily avai