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Autor:
Abdulrazaq Bidemi Nafiu, Abdulbasit Amin, Bamidele Victor Owoyele, Adedamola Bayo-Olugbami, Olalekan M. Ogundele, Charles C. Lee
Publikováno v:
Nutr Neurosci
BACKGROUND: L-DOPA, the predominant therapy for Parkinson’s disease (PD) is associated with motor deficits after prolonged use. The nigrostriatal tract, a primary target of neurodegeneration in PD, contains abundant Vitamin-D receptors, suggesting
Autor:
Celia Gellman, Jeff A. Beeler, Holly Moore, Abigail Kalmbach, Stephen Rayport, Benjamin Y. Klein, Roseanna M. Zanca, Devry Mourra, Peter A. Serrano, Susana Mingote, Rebecca Ravenelle, Nesha S. Burghardt
Publikováno v:
Biol Psychiatry
Background Increased physical activity is a common feature of anorexia nervosa (AN). Although high activity levels are associated with greater risk of developing AN, particularly when combined with dieting, most individuals who diet and exercise main
Autor:
Jaap J. Plomp, Dominic J. Wells, Christa L Tanganyika-de Winter, David Bull, Annemieke Aartsma-Rus, John C. W. Hildyard, Sofia Nnorom, K E Wells, Ingrid E.C. Verhaart, Ornella Cappellari
Publikováno v:
Journal of Neuromuscular Diseases
Journal of Neuromuscular Diseases, 8(5), 845-863. IOS PRESS
Journal of Neuromuscular Diseases, 8(5), 845-863. IOS PRESS
Duchenne muscular dystrophy is an X-linked, recessive muscular dystrophy in which the absence of the dystrophin protein leads to fibrosis, inflammation and oxidative stress, resulting in loss of muscle tissue. Drug repurposing, i.e. using drugs alrea
Autor:
L. Yang, Corinne Schneider, Vinh Dang, L. A. Van Der Kraak, J. A. Varghese, Timothy W. Hand, Eric S. Weiss, Scott W. Canna, Ansen H.P. Burr
Publikováno v:
Mucosal immunology
Major Histocompatibility Complex Class II (MHCII) is dynamically expressed on intestinal epithelial cells (IECs) throughout the intestine, but its regulation remains poorly understood. We observed that spontaneous upregulation of IEC MHCII in locally
Autor:
Yuki Kurauchi, Takeshi Masuda, Keita Kinoshita, Masanori Hijioka, Akinori Hisatsune, Kosei Matsumoto, Takahiro Seki, Hiroshi Katsuki, Sumio Ohtsuki
Publikováno v:
Neuroscience Research. 170:284-294
Here we examined the effect of nicotine on angiogenesis in the brain after intracerebral hemorrhage (ICH), as angiogenesis is considered to provide beneficial effects on brain tissues during recovery from injury after stroke. Nicotine was administere
Publikováno v:
Reproductive BioMedicine Online. 43:379-393
Research question Can preoperative or perioperative intervention reduce the risk of recurrence of endometriosis caused by either incomplete excision or spillage and dissemination? Design A mouse model of endometriosis recurrence caused by spillage an
Autor:
Yuelin Gao, Ping Pang, Xiuzhu Wang, Zhezhe Qu, Yingqiong Jia, Baofeng Yang, Weijie Du, Kuiwu Liu, Jiaming Ju, Xin Li, Xinda Yin, Xiaoqian Bi, Yu Bian, Ning Wang, Zhongting Mei, Shuting Yu, Han Wu, Qian Liu
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:128-139
Myocardial infarction (MI)-induced the activation of NLRP3 inflammasome has been well known to aggravate myocardial injury and cardiac dysfunction by causing inflammation and pyroptosis in the heart. Circular RNAs (circRNAs) have been demonstrated to
Autor:
Yoshinori Kakino, Maho Matsuo, Yuki Kawasaki, Chihiro Takada, Yuto Tamaoki, Ryu Yasuda, Shinji Ogura, Isamu Muraki, Toshiaki Taniguchi, Hirotsugu Fukuda, Shozo Yoshida, Takahito Miyake, Akio Suzuki, Hiroyuki Tomita, Ayumi Kuroda, Hideshi Okada, Ayane Nishio, Nagisa Miyazaki, Shigeo Takashima, Risa Inagawa, Yuichiro Kitagawa, Tomoaki Doi, Haruka Okamoto, Tetsuya Fukuta, Keiko Suzuki, Yugo Wakayama, Kodai Suzuki, Takahiro Yoshida
Publikováno v:
The American Journal of Pathology
Sepsis-induced endothelial acute respiratory distress syndrome is related to microvascular endothelial dysfunction caused by endothelial glycocalyx disruption. Recently, recombinant antithrombin (rAT) was reported to protect the endothelial glycocaly
Autor:
Byram W. Bridle, Alicia Viloria-Petit, Alexandra S Rasiuk, Lily Chan, Scott R. Walsh, Sarah K. Wootton, Khalil Karimi
Publikováno v:
Viral Immunology. 34:470-482
During viral infections, cells produce type I interferons (IFNs), which are detected by the IFNα/β receptor (IFNAR). To survive in hosts, viruses have strategies to downregulate IFN-mediated signaling. We hypothesized that macrophages, which are am
Publikováno v:
Trends Cancer
Autophagy is a catabolic intracellular nutrient scavenging pathway triggered by nutrient deprivation and stress that captures and degrades intracellular proteins and organelles in lysosomes. The breakdown products are then recycled into metabolic pat