Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Jeremy N. Rich, Hongzhen Tang, Yutang Mei, Ruoxin Du, Qi Xie, Jiayan Ma, Fuyi Liu, Peng Lin, Hongyan Zhang, Min Tang, Briana C. Prager, Zhen Xia, Chongran Sun, Ryan C. Gimple
Publikováno v:
Nucleic Acids Research
N6-methyladenosine (m6A) is the most common modification on endogenous RNA transcripts in mammalian cells. Currently, the lack of precise single-nucleotide RNA modification tools makes it challenging to understand the relationship between site-specif
Autor:
Zhen Dong, Kristoffer Vitting-Seerup, Xiuxing Wang, Li Jiang, Qiulian Wu, Qi Xie, Briana C. Prager, Shruti Bhargava, Reilly L. Kidwell, Jeremy N. Rich, Zhixin Qiu, Leo J.Y. Kim, Deobrat Dixit, Yang Wang, Samie R. Jaffrey, Petra Hamerlik, Hui Xian Poh, Jing Crystal Zhao, Ryan C. Gimple, Zhe Zhu
Publikováno v:
Cancer Discov
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here, we interrogated N6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA immunoprecipitation followed by sequencing and transcriptome analysis, findin
Autor:
Harish N. Vasudevan, Arie Perry, Zhe Zhu, Deobrat Dixit, Jeremy N. Rich, Qi Xie, Jean A. Bernatchez, Andrew R. Morton, Derrick Lee, Lisa C. Wallace, Qiulian Wu, Jair L. Siqueira-Neto, David R. Raleigh, Ryan C. Gimple, Briana C. Prager, Shruti Bhargava, Xiuxing Wang, Clark C. Chen, Stephen C. Mack, Gene H. Barnett, Melike Pekmezci, Lukas Chavez, Bradley H. King, M.A. Vogelbaum
Publikováno v:
Cancer Discovery. 10:1722-1741
Meningiomas are the most common primary intracranial tumor with current classification offering limited therapeutic guidance. Here, we interrogated meningioma enhancer landscapes from 33 tumors to stratify patients based upon prognosis and identify n
Autor:
Jinkyu Jung, Amber J. Giles, Orieta Celiku, Wei Zhang, Brian J. Williams, Roger Abounader, Jeremy N. Rich, Mark R. Gilbert, Deric M. Park, Ying Zhang, Hua Song
Publikováno v:
Cancer Research. 79:5218-5232
Cancer cells rely on mitochondrial functions to regulate key survival and death signals. How cancer cells regulate mitochondrial autophagy (mitophagy) in the tumor microenvironment as well as utilize mitophagy as a survival signal is still not well u
Autor:
Stephen C. Mack, Leo J.Y. Kim, Hu Cang, Zhen Dong, Deguan Lv, Jeremy N. Rich, Megan E Wolf, Reilly L. Kidwell, Qi Xie, Tao Huan, Qing Ye, J. Mark Brown, Xiuxing Wang, Tengqian Sun, Junfeng Bi, Guoxin Zhang, Derrick Lee, Ryan C. Gimple, Andrew E. Sloan, Zhe Zhu, Shruti Bhargava, Anthony D. Gromovsky, Linjie Zhao, Briana C. Prager, Li Jiang, Qiulian Wu, Paul S. Mischel
Publikováno v:
Cancer Discovery. 9:1248-1267
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSC) contribute to this poor prognosis by driving therapeutic resistance and maintaining cellular heterogeneity. To understand the m
Autor:
Courtney L.R. Jurd, Kathleen S. Ensbey, Thomas Robertson, Zara C. Bruce, Paul R. Jamieson, Carolin Offenhäuser, Rochelle C.J. D’Souza, Bryan W. Day, Fiona M. Smith, Andrew W. Boyd, Po Inglis, Rosalind L. Jeffree, Kevin P. Campbell, Seckin Akgul, Yuchen Li, Justin D. Lathia, Zarnie Lwin, Yi Chieh Lim, Jeremy N. Rich, Terrance Grant Johns, Brett W. Stringer, Krishna P.L. Bhat, Ulrich Baumgartner
Publikováno v:
Acta Neuropathologica
Glioblastomas (GBMs) are malignant central nervous system (CNS) neoplasms with a very poor prognosis. They display cellular hierarchies containing self-renewing tumourigenic glioma stem cells (GSCs) in a complex heterogeneous microenvironment. One pr
Publikováno v:
Genes & Development. 33:591-609
Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex. Although the original identification of GSCs dates back more than a decad
Publikováno v:
Cell Stem Cell. 24:41-53
Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a supportive niche. Viewed through the lens of an ecosystem, numerous tumor components have multi-directional interactions involving CSCs, supporting the complexity of tu
Autor:
Shengtao Zhou, Wei Wang, Linjie Zhao, Ryan C. Gimple, Yuan Wang, Xin Wang, Lian Xu, Jeremy N. Rich, Zhengnan Yang
Publikováno v:
Science Advances
Plasma cells shape the mesenchymal identity of ovarian cancers through exosome-mediated miR-330-3p/JAM2 axis.
Ovarian cancer represents a highly lethal disease that poses a substantial burden for females, with four main molecular subtypes carryi
Ovarian cancer represents a highly lethal disease that poses a substantial burden for females, with four main molecular subtypes carryi
Autor:
Tong Hu, Luciano Mazzoccoli, Jeremy N. Rich, Sachendra S. Bais, Michael S. Diamond, Milan G. Chheda, Hideho Okada, Pei Yong Shi, Arijita Jash, Jennifer Govero, Camila R. Fontes-Garfias, Sujan Shresta, Sharmila Nair, Chao Shan
Publikováno v:
JCI insight, vol 6, iss 1
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus (ZIKV) targets GBM stem cells and prevents death of mice with gliomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70a1ddc1d5cb1ac10ad87cd9a425e2b
https://escholarship.org/uc/item/00x665sr
https://escholarship.org/uc/item/00x665sr