Zobrazeno 1 - 10
of 14
pro vyhledávání: '"327"'
Publikováno v:
Molecules, Vol 21, Iss 3, p 327 (2016)
Molecules; Volume 21; Issue 3; Pages: 327
Molecules
Molecules; Volume 21; Issue 3; Pages: 327
Molecules
The rates of deamidation reactions of asparagine (Asn) residues which occur spontaneously and nonenzymatically in peptides and proteins via the succinimide intermediate are known to be strongly dependent on the nature of the following residue on the
Autor:
Angelita Rebollo, Bernard Caudron, Eric Deveaud, Alphonse Garcia, Fernando Roncal, Xavier Cayla
Publikováno v:
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2004, 327, pp.93-97
Comptes Rendus Biologies, Elsevier, 2004, 327, pp.93-97
Protein phosphatase 1 is regulated by the interaction between a catalytic subunit (PP1c) and multiple interacting proteins that allow the specific dephosphorylation of diverse cellular targets. This communication proposes to use the simultaneous pres
Publikováno v:
Brandl, Fabian; Busslinger, Sarah; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2020). Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life. Journal of controlled release, 327, pp. 186-197. Elsevier 10.1016/j.jconrel.2020.08.004
Despite some approvals of antibody-drug conjugates for cancer therapy, their clinical success rate is unsatisfactory because of very small therapeutic windows, influenced by on-target and off-target toxicities of conjugate and liberated toxin. Additi
Autor:
Indhira Guzmán Peralta, Laura Vilariño-Maneiro, Maria Torres Duran, Adrian Sousa, José Abal-Arca, Adolfo Baloira Villar, Eva Romay-Lema, Dolores Corbacho-Abelaira, Pedro J. Marcos, Vanessa Riveiro-Blanco, Fernando De La Iglesia Martínez, Luis Pérez de Llano, María Bustillo Casado, Nuria Rodríguez Nuñez, Christian Anchorena Diaz, Rafael Golpe, Carmen Montero Martínez, Carmen Diego-Roza
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253465 (2021)
PLoS ONE
PLoS ONE
Introduction This study was aimed to identify risk factors associated with unfavorable outcomes (composite outcome variable: mortality and need for mechanical ventilation) in patients hospitalized in Galicia with COVID-19 pneumonia. Methods Retrospec
Autor:
Shigeyuki Kawa, Masao Ota, Takeji Umemura, Hideaki Hamano, Kaname Yoshizawa, Satoru Joshita, Eiji Tanaka
Publikováno v:
Journal of Human Genetics. 62:963-967
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by an autoimmune reaction to hepatocytes. The Src homology 2 adaptor protein 3 (SH2B3) gene is a member of the SH2B family of adaptor proteins that has been implicated i
Autor:
S.-G. Choi, Hee-Won Moon, Hee-Jung Chung, Hanah Kim, Hyun Kyung Lee, Seungho Lee, Mina Hur, Yeo-Min Yun
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226477 (2019)
PLoS ONE
PLoS ONE
BackgroundVISION Max (Ortho-Clinical Diagnostics, Raritan, NJ, USA) is a newly introduced automated blood bank system. Cross-matching (XM) is an important test confirming safety by simulating reaction between packed Red Blood Cells (RBCs) and patient
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 41(4)
The primary aim of this study is to determine the value of using a combination of serum histidine-rich glycoprotein (HRG) level and uterine artery pulsatility index (PI) in pregnant women at 11-13+6 weeks' gestation to predict preeclampsia. The secon
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 13, Iss 8, p e1002072 (2016)
PLoS Medicine, Vol 13, Iss 8, p e1002072 (2016)
Background Diabetes is a well-known risk factor for tuberculosis (TB) and is increasingly prevalent in low- and middle-income countries, where the burden of TB is high. Glycemic control has the potential to modify the risk of TB. However, there are f
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158756 (2016)
PLoS ONE
PLoS ONE
Stathmin 1 (STMN1) is a neuronal growth-associated protein that is involved in microtubule dynamics and plays an important role in synaptic outgrowth and plasticity. Given that STMN1 affects fear behavior, we hypothesized that genetic variations in t
Autor:
Castrense Savojardo, Pier Luigi Martelli, Giulia Babbi, Piero Fariselli, Francesco Aggazio, Rita Casadio
Publikováno v:
BMC Genomics
none 6 no Background: Modern genomic techniques allow to associate several Mendelian human diseases to single residue variations in different proteins. Molecular mechanisms explaining the relationship among genotype and phenotype are still under deba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b81e4a9305351eb6c1a0f26f41ecd5e
http://hdl.handle.net/2318/1687509
http://hdl.handle.net/2318/1687509