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Autor:
Marko Pregel, Jia Liu, Edward B. Stevens, Yiting Wang, David N. Sheppard, Walailak Jantarajit, Lishuang Cao, Allison P. Berg, Katy J. Sutcliffe
Publikováno v:
British Journal of Pharmacology. 179:1319-1337
BACKGROUND AND PURPOSE Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl- channels at the plasma membrane to en
Autor:
Jitsuo Usuda, Susumu Takeuchi, Kengo Nagashima, Noriko Motoi, Masahiro Seike, Jun Matsubayashi, Hideaki Shiraishi, Kazufumi Honda, Shun-ichi Watanabe, Rintaro Noro, Kaoru Kubota, Xue Meng, Tatsuya Inoue, Huang Wilber, Ayumi Kashiro, Tetsuya Okano, Yukihiro Yoshida, Shinobu Kunugi, Akihiko Gemma, Norihiko Ikeda
Publikováno v:
Cancer Science. 113:1002-1009
Although adjuvant tegafur/uracil (UFT) is recommended for patients with completely resected stage I non-small cell lung cancer (NSCLC) in Japan, only one-third of cases has received adjuvant chemotherapy according to real-world data. Therefore, robus
Autor:
Ting-An Chou, Yi-Fang Huang, Chung-Yi Nien, Hsiang-Hsi Hong, Chao-Hua Liang, Adrienne Hong, Hui-Yi Hsiao, Tzung-Hai Yen, Alex Hong
Publikováno v:
Journal of Periodontology. 93:1553-1565
BACKGROUNDS Alveolar bone and cementum share many biological and developmental similarities. The mineralizing effect of calcitriol has been previously reported. Yet, its cementoinductivity has not been confirmed. This study evaluated the potential ce
Publikováno v:
Environmental Toxicology and Chemistry. 41:396-409
The derivation of protective values for aquatic life can be enhanced by the development and use of bioavailability models. Recent advances to metals bioavailability modeling are applicable to other analyte groups and should be widely considered. In t
Autor:
Kateryna Kovalenko, Yoonsun Mo, Natalia Shcherbakova, Wai Kin Li, Joshua Rosenberg, Kelsey L. Inman, Jose Orsini
Publikováno v:
The Journal of Clinical Pharmacology. 62:359-365
The use of population pharmacokinetics (PK) to optimize cefepime dosing could be an effective strategy, given the increasing prevalence of resistant gram-negative organisms. The objective of this study is to retrospectively compare dosing using PK ap
Publikováno v:
Arthritis Care & Research. 74:187-198
To understand the epidemiology, current treatment, and disease burden of systemic lupus erythematosus (SLE) in the Asia Pacific (APAC) region.A targeted literature review of published evidence on SLE in the APAC region was conducted, using the Medlin
Publikováno v:
The Canadian Journal of Chemical Engineering. 100:3063-3079
Publikováno v:
The Journal of Clinical Pharmacology. 62:646-655
This study aimed to characterize adverse drug reactions (ADRs) to hydroxychloroquine in the setting of Covid-19, occurring in Italy in the period March-May 2020. The analysis of the combination therapy with azithromycin or/and lopinavir/ritonavir as
Risk of Pregabalin‐Induced Hypoglycemia: Analysis of the Japanese Adverse Drug Event Report Database
Autor:
Masashi Neo, Junko Makino, Kaoru Suzuki, Masami Nishihara, Tomoyuki Yamada, Satoru Mitsuboshi
Publikováno v:
The Journal of Clinical Pharmacology. 62:756-761
Pregabalin is a first-line treatment option for neuropathic pain. Recently, some cases of pregabalin-induced hypoglycemia have been reported, which can complicate the treatment of neuropathic pain and worsen patient outcomes. Therefore, a better unde
Publikováno v:
The Journal of Clinical Pharmacology. 62:594-608
Anti-vascular endothelial growth factor (VEGF) therapy is used to slow the disease progression of neovascular age-related macular degeneration. Due to the treatment burden of frequent intravitreal injections, anti-VEGFs are often used on treat and ex