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Autor:
Surakameth Mahasirimongkol, Fei Hou, Pattarin Tangtanatakul, Wei Wei, Qin Song, Yan Zhang, Zhiming Lin, Xinyu Zhang, Yao Lei, Yu-Lung Lau, Xiao Qin, Prapaporn Pisitkun, Nusara Satproedprai, Lichuan Zheng, Chengmin Qian, Li Shao, Nattiya Hirankarn, Wanling Yang, Yong-Fei Wang
Publikováno v:
Arthritis & Rheumatology. 74:840-848
Objectives Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with differences in prevalence and severity among ancestral groups. This study aims to identify novel genetic components either shared or distinct between Asian and Europ
Autor:
Stefania Tommasi, Letizia Porcelli, Roberta Di Fonte, Simona De Summa, Rosanna Lacalamita, Amalia Azzariti, Brunella Pilato, Katia Danza, Simona Serratì
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 904-920 (2022)
Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcit
Autor:
Sarah J. Freemantle, Megan Tomlin, Khadeeja Shahid, Andrea K. Corbet, Aleyah Hattab, Emmanuel Bikorimana, Hannah Baldwin, Raya I. Boyd, Ratnakar Singh, Cliff Yerby, Doha Shokry, Zeeshan Fazal, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Molecular Oncology
Molecular Oncology
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Autor:
Roberto Maria Pellegrino, Carla Emiliani, Matteo Caleo, Lucia Angella, Gabriele Parlanti, Ambra Del Grosso, Sara Carpi, Nadia Giordano, Elisa Ottalagana, Ilaria Tonazzini, Marco Cecchini, Husam B. R. Alabed
Publikováno v:
JIMD Reports, Vol 63, Iss 1, Pp 50-65 (2022)
JIMD Reports
JIMD reports
63 (2022): 50–65. doi:10.1002/jmd2.12258
info:cnr-pdr/source/autori:Del Grosso A.; Parlanti G.; Angella L.; Giordano N.; Tonazzini I.; Ottalagana E.; Carpi S.; Pellegrino R.M.; Alabed H.B.R.; Emiliani C.; Caleo M.; Cecchini M./titolo:Chronic lithium administration in a mouse model for Krabbe disease/doi:10.1002%2Fjmd2.12258/rivista:JIMD reports (Print)/anno:2022/pagina_da:50/pagina_a:65/intervallo_pagine:50–65/volume:63
JIMD Reports
JIMD reports
63 (2022): 50–65. doi:10.1002/jmd2.12258
info:cnr-pdr/source/autori:Del Grosso A.; Parlanti G.; Angella L.; Giordano N.; Tonazzini I.; Ottalagana E.; Carpi S.; Pellegrino R.M.; Alabed H.B.R.; Emiliani C.; Caleo M.; Cecchini M./titolo:Chronic lithium administration in a mouse model for Krabbe disease/doi:10.1002%2Fjmd2.12258/rivista:JIMD reports (Print)/anno:2022/pagina_da:50/pagina_a:65/intervallo_pagine:50–65/volume:63
Krabbe disease (KD; or globoid cell leukodystrophy) is an autosomal recessive lysosomal storage disorder caused by deficiency of the galactosylceramidase (GALC) enzyme. No cure is currently available for KD. Clinical applied treatments are supportive
Autor:
Joachim Weischenfeldt, Hans Skovgaard Poulsen, Petra Hamerlik, Olga Østrup, Christina Westmose Yde, Aidan Flynn, Jannick Brennum, Dorte Schou Nørøxe, Finn Cilius Nielsen, Ulrik Lassen, Jane Skjøth-Rasmussen
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 206-218 (2022)
Molecular Oncology
Nørøxe, D S, Flynn, A, Yde, C W, Østrup, O, Cilius Nielsen, F, Skjøth-Rasmussen, J, Brennum, J, Hamerlik, P, Weischenfeldt, J, Skovgaard Poulsen, H & Lassen, U 2022, ' Tumor mutational burden and purity adjustment before and after treatment with temozolomide in 27 paired samples of glioblastoma : a prospective study ', Molecular Oncology, vol. 16, no. 1, pp. 206-218 . https://doi.org/10.1002/1878-0261.13015
Molecular Oncology
Nørøxe, D S, Flynn, A, Yde, C W, Østrup, O, Cilius Nielsen, F, Skjøth-Rasmussen, J, Brennum, J, Hamerlik, P, Weischenfeldt, J, Skovgaard Poulsen, H & Lassen, U 2022, ' Tumor mutational burden and purity adjustment before and after treatment with temozolomide in 27 paired samples of glioblastoma : a prospective study ', Molecular Oncology, vol. 16, no. 1, pp. 206-218 . https://doi.org/10.1002/1878-0261.13015
Treatment of glioblastoma (GBM) remains a challenging task, with limited treatment options, none offering a cure. Immune therapy has proven effective across different cancers with remarkable response rates. Tumor mutational burden (TMB) is a marker o
Publikováno v:
American Journal of Medical Genetics Part A. 188:828-835
Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder based on a loss of paternally expressed genes in chromosome region 15q11-13. In addition to typical characteristics such as hyperphagia, PWS is evidenced by a certain behavioral phenot
Publikováno v:
FEBS Letters. 595:3042-3055
Selenium is an essential trace element of interest for its potential role in glucose homeostasis. The present study investigated the impact of selenium supplementation as selenomethionine (SeMet) on insulin secretion in MIN6-K8 cells, a pancreatic β
Autor:
Esmail Pagheh, Seyyed Morteza Hoseini, Hien Van Doan, Seyed Hossein Hoseinifar, Ali Taheri Mirghaed
Publikováno v:
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 337:227-237
The aim of this study was to assess the anesthetic efficacy and biochemical effects of citronellal on rainbow trout, Oncorhynchus mykiss. The fish were exposed to 200-800 µl/L citronellal to find the anesthesia induction and recovery times. The deep
Publikováno v:
American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 187:549-560
We previously reported increased pain and gastrointestinal (GI) medication prescription claims among persons with Ehlers-Danlos syndromes (EDS) and peripubertal increase in opioid and anti-emetic claims among women with EDS. Herein, we hypothesized a
Publikováno v:
FEBS Letters
Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid screening and co-immunop