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Autor:
Helene Minyi Liu
Publikováno v:
IUBMB Life. 74:180-189
The induction of type I interferons (IFN) is critical for antiviral innate immune response. The rapid activation of antiviral innate immune responses is the key to successful clearance of evading pathogens. To achieve this, a series of proteins, incl
Publikováno v:
FEBS Letters. 595:2628-2637
We recently reported a physical interaction between the angiotensin II (AngII) receptor (AT1R) and thrombin receptor (PAR1) in HEK293 cells using bioluminescence resonance energy transfer (BRET) technology. This was characterized by thrombin trans-ac
Publikováno v:
FEBS Lett
Pleiotrophin (PTN) is a potent mitogenic cytokine whose activities are controlled by its interactions with glycosaminoglycan (GAG). We examined the specificity of PTN for several types of GAG oligosaccharides. Our data indicate that the interaction o
Autor:
Ritu Mishra, Kaitlyn M. Eckert, Carole R. Mendelson, Yaqin Yu, Lu Gao, Jeffrey G. McDonald, Jingfei Chen
Publikováno v:
The FASEB Journal. 34:16243-16261
Our previous research revealed that steroid receptor coactivators (Src)-1 and -2 serve a critical cooperative role in production of parturition signals, surfactant protein A and platelet-activating factor, by the developing mouse fetal lung (MFL). To
Autor:
Yingbi Zhou, Gang Yu, Tingting Guo, Jing Leng, Yingzhan Zhang, Yineng Xu, Ruhui Zeng, Bin Liu, Jiahui Ge
Publikováno v:
The FASEB Journal. 34:16105-16116
Vasomotor reactions of prostacyclin (prostaglandin I2 ; PGI2 ) can be collectively modulated by thromboxane prostanoid receptor (TP), E-prostanoid receptor-3 (EP3), and the vasodilator I prostanoid receptor (IP). This study aimed to determine the dir
Autor:
Umeharu Ohto, Roderic G. Eckenhoff, Sophia Koutsogiannaki, Miho Shibamura-Fujiogi, Lifei Hou, Koichi Yuki, H. Ishida, Weiming Bu
Publikováno v:
FASEB J
Toll like receptors (TLRs) are critical receptors to respond to danger signals, and their functions are relevant in the perioperative period. We previously reported that volatile anesthetics directly bound to TLR2 and TLR4 and attenuated their functi
Publikováno v:
The FASEB Journal. 34:13993-14005
Many factors are involved in the process of nerve regeneration. Understanding the mechanisms regarding how these factors promote an efficient remyelination is crucial to deciphering the molecular and cellular processes required to promote nerve repai
Publikováno v:
FEBS Lett
Inflammasomes are cytosolic multimeric signaling complexes of the innate immune system that induce activation of caspases. The NOD-like receptor NLRP9 recruits the adaptor protein ASC to form an ASC-dependent inflammasome to limit rotaviral replicati
Autor:
Javad Jalili, Ainaz Mihanfar, Mohammad Mirza-Aghazadeh-Attari, Parisa Hajalioghli, Russel J. Reiter, Reza Rikhtegar, Maryam Majidinia, Bahman Yousefi
Publikováno v:
IUBMB Life. 72:1560-1584
Melatonin (N-acetyl-5-methoxytryptamine), a pleotropic molecule with a wide distribution, has received considerable attention in recent years, mostly because of its various major effects on tissues or cells since it has both receptor-dependent and re
Autor:
A. O. Shpakov, Kira V. Derkach, Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Roy, Malsawmhriatzuala Jeremy
Publikováno v:
Molecular Reproduction and Development. 87:620-629
Diabetes mellitus impairs testicular activity and leads to infertility. Leptin is one of the endogenous regulators of the male reproductive functions, but the role of leptin and its receptor (LEPR/Ob-R) in the control of testosterone production and t