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Autor:
Yue Xing, Hong Xiang Zuo, Ming Yue Li, Zhi Hong Zhang, Juan Ma, Xuejun Jin, Jing Ying Wang, Hong Lan Jin
Publikováno v:
British Journal of Pharmacology. 179:1887-1907
ZFP91 positively regulates IL-1β production in macrophages and may be a potential therapeutic target to treat inflammatory-related diseases. We investigated whether this process is modulated by convallatoxin, which is a cardiac glycoside isolated fr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 199-211 (2022)
Finerenone is a nonsteroidal, selective mineralocorticoid receptor antagonist (MRA) that recently demonstrated its efficacy to delay chronic kidney disease (CKD) progression and reduce cardiovascular events in patients with CKD and type 2 diabetes. H
Autor:
Roger A. Jones, Barbara L. Gaffney
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
This unit describes the specific incorporation of (15)N into the N7 and amino positions of adenosine, and conversion of the adenosine to guanosine labeled at the N1, N7, and amino positions. Two variations of the procedures are also presented that in
Autor:
Patrick Trouillas, J. Javellaud, Václav Bazgier, Nicolas Picard, Pierre Marquet, Petra Čechová, Souleiman El Balkhi, Michal Otyepka, Franck Saint-Marcoux, Roland Lawson, Eliès Zarrouk
Publikováno v:
British Journal of Pharmacology. 180:829-842
BACKGROUND AND PURPOSE Opioids and benzodiazepines are frequently combined in medical as well as in non-medical contexts. At high doses, such combinations often result in serious health complications attributed to pharmacodynamics interactions. Here,
Publikováno v:
British Journal of Pharmacology. 179:1338-1352
BACKGROUND AND PURPOSE Prostacyclin mimetics express potent vsoactive effects via prostanoid receptors which are not defined unequivocally, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of
Publikováno v:
Environmental Toxicology and Chemistry. 41:396-409
The derivation of protective values for aquatic life can be enhanced by the development and use of bioavailability models. Recent advances to metals bioavailability modeling are applicable to other analyte groups and should be widely considered. In t
Risk of Pregabalin‐Induced Hypoglycemia: Analysis of the Japanese Adverse Drug Event Report Database
Autor:
Masashi Neo, Junko Makino, Kaoru Suzuki, Masami Nishihara, Tomoyuki Yamada, Satoru Mitsuboshi
Publikováno v:
The Journal of Clinical Pharmacology. 62:756-761
Pregabalin is a first-line treatment option for neuropathic pain. Recently, some cases of pregabalin-induced hypoglycemia have been reported, which can complicate the treatment of neuropathic pain and worsen patient outcomes. Therefore, a better unde
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 1, Pp 253-258 (2022)
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Background There is a paucity of veterinary literature on the safety or outcome of zoledronic acid (ZA) use in dogs for either bone pain or hypercalcemia. Hypothesis/Objectives The primary aim was to report the adverse events in dogs receiving intrav
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 1, Pp 272-278 (2022)
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
A 14‐year‐old male castrated domestic medium‐hair cat with diabetes mellitus was evaluated for vomiting, diarrhea, and anorexia. Two weeks before presentation, the cat had been diagnosed with congestive heart failure and started on furosemide.
Autor:
Tomoaki Nakajima, Keizo Anzai, Atsushi Kawaguchi, Osamu Kurai, Yoshihito Kubotsu, Ayako Takamori, Hirokazu Takahashi, Michihiro Nonaka, Hideyuki Hyogo, Masafumi Ono, Satoshi Oeda, Miwa Kawanaka, Yuichiro Eguchi, Kenichi Tanaka, Kento Imajo, Masato Yoneda, Masayoshi Kage, Shinichi Aishima, Takaomi Kessoku, Yoichiro Kitajima, Ryo Tajiri, Atsushi Nakajima, Hiroshi Isoda, Hideki Fujii
Publikováno v:
Hepatology Communications, Vol 6, Iss 1, Pp 120-132 (2022)
Hepatology Communications
Hepatology Communications
Sodium glucose cotransporter‐2 inhibitors (SGLT2is) are now widely used to treat diabetes, but their effects on nonalcoholic fatty liver disease (NAFLD) remain to be determined. We aimed to evaluate the effects of SGLT2is on the pathogenesis of NAF