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Autor:
Kristen R. Breit, Irene Shkolnikov, Hannah M.O. Reid, Cristina G. Rodriguez, Taylor M. Snowden, Jennifer D. Thomas, Brian R. Christie
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: We have recently shown that alcohol and cannabis can interact prenatally, and in a recent review paper we further identified Parvalbumin-positive (PV) interneurons in the hippocampus as a potential point of convergence for these teratogen
Publikováno v:
Cancer Medicine, Vol 10, Iss 15, Pp 5235-5245 (2021)
Cancer Medicine
Cancer Medicine
Background Histone deacetylases (HDACs) have been demonstrated to be aberrantly activated in tumorigenesis and cancer development. Thus, HDAC inhibitors (HDACIs) are considered to be promising anti‐cancer therapeutics. However, recent studies have
Autor:
Steve F. Perry, William Joyce
Publikováno v:
Joyce, W & Perry, S F 2021, ' Hif-1α is not required for the development of cardiac adrenergic control in zebrafish (Danio rerio) ', Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, vol. 335, no. 7, pp. 623-631 . https://doi.org/10.1002/jez.2507
Adrenergic regulation, acting via the sympathetic nervous system, provides a major mechanism to control cardiac function. It has recently been shown that hypoxia inducible factor-1α (Hif-1α) is necessary for normal development of sympathetic innerv
Autor:
Oscar Della Pasqua, Sean Oosterholt
Publikováno v:
British Journal of Clinical Pharmacology. 87:4718-4725
AIMS Raxibacumab is a fully humanized monoclonal antibody that blocks the interaction of Bacillus anthracis toxins, thereby protecting target cells from its effects. Raxibacumab is approved in the USA for the treatment of adults and children with inh
Publikováno v:
Angewandte Chemie (International Ed. in English)
Modafinil, a widely used psychoactive drug, has been shown to exert a positive impact on cognition and is used to treat sleep disorders and hyperactivity. Using time‐of‐flight secondary ion mass spectrometric imaging, we studied the changes of br
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1423-1430 (2021)
Clinical and Translational Science
Clinical and Translational Science
Durlobactam (formerly ETX2514) is a diazabicyclooctane β‐lactamase inhibitor that inhibits class A, C, and D β‐lactamases. Sulbactam combined with durlobactam has in vitro and in vivo activity against Acinetobacter baumannii including carbapene
Autor:
Wenpeng Ma, Zixin Cui, Miaomiao Zhang, Feng Ye, Songmei Geng, Zhihong Yao, Xinwu Niu, Chengcheng Liu, Xiaopeng Wang, Yanyan Zhu
Publikováno v:
Microbial Biotechnology. 15:499-512
Trichophyton rubrum is responsible for the majority of dermatophytosis. Current systemic and topical antifungals against dermatophytosis are often tedious and sometimes unsatisfactory. Antimicrobial photodynamic therapy (aPDT) is a non-invasive alter
Autor:
Mahbubur Rahman, Shane R. Wilkinson, Aishah Mahmood, Ambika Dattani, Isatou Drammeh, Joanna Szular
Publikováno v:
Molecular Microbiology. 116:674-689
Nitroheterocycles represent an important class of compound used to treat trypanosomiasis. They often function as prodrugs and can undergo type I nitroreductase (NTR1)-mediated activation before promoting their anti-parasitic activities although the n
Autor:
Jukka Ollgren, Emilia Attman, Outi Lyytikäinen, Reetta Huttunen, Risto Vuento, Jaana Syrjänen, Marjatta Sinisalo, Erja Mattila
Publikováno v:
European Journal of Haematology. 107:311-317
OBJECTIVES The aim was to identify the clinical characteristics, outcome, and antimicrobial susceptibility of healthcare-associated bloodstream infections (BSIs) in hematological patients. METHODS This retrospectively collected laboratory-based surve
Autor:
Jie Huang, Hailiang Wang, Ge Li, Ziyan Wang, Xinshu Li, Chengyin Shi, Ting Li, Qingli Zhang, Guosi Xie, Miao Gong, Ping Wang, Xiaoyuan Wan
Publikováno v:
Journal of Fish Diseases. 44:1543-1552
A novel pathogenic strain Vibrio 20190611023 was isolated from the hepatopancreas of moribund cultured Penaeus vannamei suffering from black gill disease. This strain was identified as V. brasiliensis based on the phylogenetic analyses of 16S rDNA ge