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Autor:
Kenneth D. Roth, Valentina Pirro, Kevin L. Duffin, Jonathan M. Wilson, Yanzhu Lin, Jill A. Willency, Axel Haupt, Paul L. Milligan, Christopher B. Newgard, Giacomo Ruotolo
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:363-378
Context Tirzepatide substantially reduced hemoglobin A1c (HbA1c) and body weight in subjects with type 2 diabetes (T2D) compared with the glucagon-like peptide 1 receptor agonist dulaglutide. Improved glycemic control was associated with lower circul
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:e1-e24
Context The increasing burden of diabetic kidney disease (DKD) has led to the discovery of novel therapies. Objective This review aims to summarize the results of recent clinical trials that test the efficacy of potential therapies for DKD. Methods A
Autor:
Conor F. Murphy, John V. Reynolds, Jason P. Mcmorrow, Brendan Moran, Neil G. Docherty, Carel W. le Roux, Jessie A Elliott, Anthony P. Goldstone, Nicholas Rs Stratford, Narayanasamy Ravi, Marie Louise Healy
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:e204-e216
Background Recurrence-free patients after esophageal cancer surgery face long-term nutritional consequences, occurring in the context of an exaggerated postprandial gut hormone response. Acute gut hormone suppression influences brain reward signaling
Autor:
Heiko Krude, Uta Neumann, John Porter, Bernard Voet, Martin J. Whitaker, Katarina Braune, Oliver Blankenstein, Dena Digweed, Richard J. Ross, Susanna Wiegand
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Children with congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) require daily hydrocortisone replacement with accurate dosing. Objective Prospective study of efficacy and safety of hydrocortisone granules in children with AI
Autor:
Svetlana Lajic, Annelies Van't Westeinde, Nelly Padilla, Valeria Messina, Marius Zimmermann, Leif Karlsson
Publikováno v:
Van't Westeinde, A, Zimmermann, M, Messina, V, Karlsson, L, Padilla, N & Lajic, S 2020, ' First Trimester DEX Treatment Is Not Associated with Altered Brain Activity During Working Memory Performance in Adults ', The Journal of clinical endocrinology and metabolism, vol. 105, no. 11 . https://doi.org/10.1210/clinem/dgaa611
The Journal of Clinical Endocrinology and Metabolism
The Journal of Clinical Endocrinology and Metabolism
Context Prenatal dexamethasone (DEX) treatment is sometimes used in pregnancies at risk for congenital adrenal hyperplasia (CAH) to prevent virilization in female fetuses with CAH. In boys and in fetuses not having CAH, there is no benefit of early D
Autor:
Rachel Small, Lee J Middleton, Davor Jurkovic, Yacoub Khalaf, Arri Coomarasamy, Khashia Mulbagal, Andrew Sizer, Martyn Underwood, Pratima Gupta, Mark D. Kilby, Samantha Farrell-Carver, Justin Chu, Kristien Boelaert, Ayman Ewies, Natalie Nunes, Rina Agrawal, Raj Rai, Lynne Robinson, Shiao Chan, Aurelio Tobias, Kalsang Bhatia, Edmond Edi-Osagie, Paul P. Smith, Siobhan Quenby, Rima K Dhillon-Smith, Jane P Daniels, Caroline Overton, Kirandeep K Sunner, Jackie Ross, Ruth Bender-Atik, Tarek Ghobara, Shakila Thangaratinam, Krystyna Baker, Nick Raine-Fenning
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:2667-2677
Objective To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception. Design Observational cohort study. Setting A total of 49 hospitals across the United Kingdom bet
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Objective To evaluate the efficacy of insulin sensitizers on menstrual frequency, sex hormone, and metabolic parameters in overweight women with polycystic ovary syndrome (PCOS). Methods We searched multiple databases from inception to September 2019
Autor:
Qingfeng Cheng, Zhengping Feng, Shumin Yang, Linqiang Ma, Zhipeng Du, Hikaru Hashimura, Zhihong Wang, Jinbo Hu, Qifu Li, Wenwen He, Kanran Wang, Jun Yang, Ying Song, Peter J. Fuller
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e2449-e2456
Context The Endocrine Society Guidelines for the diagnosis of primary aldosteronism (PA) suggest that confirmatory tests (CFT) are not required when the following criteria are met: plasma aldosterone concentration (PAC) is >20 ng/dL, plasma renin is
Autor:
Donna M. O'Neil, Wiebke Arlt, John A.H. Wass, Christopher J Mowatt, Joanne L. Fallowfield, Janet M. Lord, John Komninos, Angela E Taylor, Dimitra Vassiliadi, Irina Bancos, Alessandro Prete, Radu Mihai, Violet Fazal-Sanderson, Sibylle Kohler, Djillali Annane, Brian G. Keevil, David J. Smith, Mark A. Foster, Niki Karavitaki
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Patients with adrenal insufficiency require increased hydrocortisone cover during major stress to avoid a life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective To identify the most appro
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:1670-1681
ContextThe goal of the meta-analysis was to evaluate the effect of pioglitazone on the primary and secondary prevention of cardiovascular diseases (CVDs) and renal adverse events in patients with or at high risk of type 2 diabetes mellitus (T2DM).Des