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Autor:
Gustavo Garcia, Beibei Wu, Spyridon Hasiakos, Sonal Srikanth, Vaithilingaraja Arumugaswami, Arunachalam Ramaiah
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 208, iss 1
ORAI1 and stromal interaction molecule 1 (STIM1) are the critical mediators of store-operated Ca2+ entry by acting as the pore subunit and an endoplasmic reticulum–resident signaling molecule, respectively. In addition to Ca2+ signaling, STIM1 is a
Publikováno v:
The Journal of Immunology. 207:1001-1008
Mast cells express multiple metabotropic purinergic P2Y receptor (P2YR) subtypes. Few studies have evaluated their role in human mast cell (HMC) allergic response as quantified by degranulation induced by cross-linking the high-affinity IgE receptor
Autor:
Isuzu Kobayashi, Tatsufumi Goto, Hideki Wakui, Kumi Ubukawa, Ken Asanuma, Yumi Sasaki, Naoto Takahashi, Yong-Mei Guo, Kenichi Sawada
Publikováno v:
The Journal of Immunology. 207:1078-1086
Emergency granulopoiesis, also known as demand-adapted granulopoiesis, is defined as the response of an organism to systemic bacterial infections, and it results in neutrophil mobilization from reservoir pools and increased myelopoiesis in the bone m
Autor:
Shun Li, Yong-An Zhang, Dan-Dan Chen, Yu Zhou, Zhuo-Cong Li, Yi Lei, Xiao-Yu Zhou, Long-Feng Lu, Can Zhang
Publikováno v:
The Journal of Immunology. 207:784-798
In mammals, cyclic GMP-AMP synthase (cGAS) recognizes cytosolic dsDNA to induce the type I IFN response. However, the functional role of cGAS in the IFN response of fish remains unclear or controversial. In this study, we report that cGAS orthologs f
Publikováno v:
The Journal of Immunology. 207:661-670
Inflammation contributes to the pathogenesis and morbidity of wide spectrum of human diseases. The inflammatory response must be actively controlled to prevent bystander damage to tissues. Yet, the mechanisms controlling excessive inflammatory respon
Autor:
Ariunaa Sampilvanjil, Tadayoshi Karasawa, Hiroshi Kurosu, Yasuchika Takeishi, Masafumi Takahashi, Kenji Tago, Naoya Yamada, Yutaka Miura, Kenta Fujimura, Makoto Kuro-o, Chintogtokh Baatarjav, Takanori Komada, Fumiya Anzai, Takayoshi Matsumura
Publikováno v:
ImmunoHorizons. 5:602-614
Calciprotein particles (CPPs) are nanoparticles composed of calcium phosphate crystals and fetuin-A and have been implicated in diseases associated with inflammation. In the current study, we investigated the molecular mechanisms underlying CPP-induc
Publikováno v:
J Immunol
The adaptor protein TNFR-associated factor 3 (TRAF3) is required for in vivo T cell effector functions and for normal TCR/CD28 signaling. TRAF3-mediated enhancement of TCR function requires engagement of both CD3 and CD28, but the molecular mechanism
Autor:
Jasmin Corso, Enas Hallumi, Arthur Weiss, Deborah Yablonski, Meirav Sela, Dvora Beach, Henning Urlaub, Wan-Lin Lo, Ilana Oz, Samuel Wittman, Rose Shalah, Amy Isenberg
Publikováno v:
J Immunol
The costimulatory receptor CD28 synergizes with the TCR to promote IL-2 production, cell survival, and proliferation; yet the obligatory interdependence of TCR and CD28 signaling is not well understood. Upon TCR stimulation, Gads, a Grb2-family adapt
Autor:
Guiliang Xu, Haijuan Gu, Shiqiang Li, Mingyao Liu, Chunlei Feng, Biao Zheng, Shuhua Han, Dali Li, Qing Li, Lingyun Li
Publikováno v:
The Journal of Immunology. 206:2338-2352
Macrophage polarization is a dynamic and integral process in tissue inflammation and remodeling. In this study, we describe that lipoprotein-associated phospholipase A2 (Lp-PLA2) plays an important role in controlling inflammatory macrophage (M1) pol
Autor:
Qiu-Ying Han, Yuan Chen, Li Ailing, Na Wang, Zeng-Lin Guo, Tao Zhou, Zhao-Shan Liu, Kun He, Hong Cai, Tao Li, Jiang-Man Zhao, Xue-Min Zhang, Feng Zhang, Tian Xia, Liang Chen, Wen Xue, Jie Mao, Weihua Li, Xin Liu, Li-Ming Sun
Publikováno v:
The Journal of Immunology. 206:2453-2467
The detection of intracellular nucleic acids is a fundamental mechanism of host defense against infections. The dysregulated nucleic acid sensing, however, is a major cause for a number of autoimmune diseases. In this study, we report that GTPase-act