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Publikováno v:
Glycoconjugate Journal. 39:725-735
A homogeneous polysaccharide named as LJW2F2 was extracted and purified from the flowers of Lonicera japonica Thunb. Structural characteristic indicated that LJW2F2 was a homogalacturonan composed of α-1,4-D-galacturonic acid with a molecular weight
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 58:539-548
Mesenchymal stem cells can be differentiated into tissue-specific cells. MicroRNAs (miRNAs) regulate the translation of mRNAs involved in the growth and development of a variety of cells, including primordial germ cells (PGCs). This study evaluated m
Publikováno v:
Human Cell. 35:1591-1601
The aim of this study was to investigate the biological function and molecular mechanism of ARPC1A (actin related protein 2/3 complex subunit 1A) in prostate cancer progression. RT-qPCR and IHC results showed that the level of ARPC1A in prostate canc
Autor:
Juan Jose Rodriguez-Sevilla, Marta Salido, Maria Rodriguez-Rivera, Blanca Sanchez-Gonzalez, Fernando Gallardo, Ramon Maria Pujol, Luis Colomo
Publikováno v:
Virchows Archiv. 481:967-973
Deregulation of JAK-STAT pathway seems to be relevant in mycosis fungoides (MFs). We report the case of a 23-year-old woman diagnosed of atypical MF carrying isolated PCM1::JAK2 fusion and eosinophilia. The disease was refractory to common treatments
Publikováno v:
Journal of Muscle Research and Cell Motility. 43:135-145
Skeletal muscle dysfunction is a common comorbidity of chronic obstructive pulmonary disease (COPD), and the molecular mechanisms regarding to the pathogenesis of this disease have not been elucidated. In this study, a novel miR-145-5p was significan
Autor:
Zhangyu, Yao, Xiang, Li, Jun, Gao, Yutao, Wang, Linmei, Xiao, Xinxia, Chang, Fangzhou, Liu, Zhenqing, Feng, Xiao, Zhang
Publikováno v:
Human Cell. 35:1464-1474
Disulfiram (DSF), which is an inhibitor of aldehyde dehydrogenase (ALDH) and approved by the FDA for the treatment of alcoholism previously, has been repurposed for use as a cancer treatment because of its potent effect in preclinical studies. In thi
Publikováno v:
Apoptosis. 27:590-605
This study aimed to investigate the role and regulatory mechanism of RNF126 in nasopharyngeal carcinoma. Firstly, the expression and prognosis of RNF126 were analyzed by TCGA database. The expression of RNF126 was further verified by NPC tissue sampl
Modulation of CREB and its associated upstream signaling pathways in pesticide-induced neurotoxicity
Publikováno v:
Molecular and Cellular Biochemistry. 477:2581-2593
Human beings are exposed to various environmental xenobiotics throughout their life consisting of a broad range of physical and chemical agents that impart bodily harm. Among these, pesticide exposure that destroys insects mainly by damaging their ce
Publikováno v:
Cell Death & Differentiation. 29:2275-2287
Autophagy targets cytoplasmic materials for degradation, and influences cell health. Alterations in Atg6/Beclin-1, a key regulator of autophagy, are associated with multiple diseases. While the role of Atg6 in autophagy regulation is heavily studied,
Autor:
Björn Schneider, Doreen William, Nora Lamp, Annette Zimpfer, Christian Henker, Carl Friedrich Classen, Andreas Erbersdobler
Publikováno v:
Molecular and Cellular Biochemistry. 477:2297-2307
Glioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal prognosis. One frequent, putative driver mutation is the genomic amplification of the oncogenic receptor tyros