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Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________70::9aea084d0d9240e6199470c1313c453a
https://dspace.lib.cranfield.ac.uk/handle/1826/19899
https://dspace.lib.cranfield.ac.uk/handle/1826/19899
Autor:
Susanna Koivuluoma, Sandra Vorimo, Tiina M. Mattila, Anna Tervasmäki, Timo Kumpula, Outi Kuismin, Robert Winqvist, Jukka Moilanen, Tuomo Mantere, Katri Pylkäs
TINF2 is a critical subunit of the shelterin complex, which protects and maintains the length of telomeres. Pathogenic missense and truncating TINF2 mutations are causative for dyskeratosis congenita (DC), a rare, dominantly inherited bone marrow fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82ca51eaee43bed77387d88cb2876ed
http://urn.fi/urn:nbn:fi-fe2023053150756
http://urn.fi/urn:nbn:fi-fe2023053150756
Autor:
Michelle C. Turner, Esther Gracia-Lavedan, Kyriaki Papantoniou, Nuria Aragonés, Gemma Castaño-Vinyals, Trinidad Dierssen-Sotos, Pilar Amiano, Eva Ardanaz, Alba Marcos-Delgado, Ana Molina-Barceló, Juan Alguacil, Yolanda Benavente, Thalia Belmonte, José J. Jiménez-Moleón, Rafael Marcos-Gragera, Beatriz Pérez, Inés Gómez-Acebo, Marina Pollán, Manolis Kogevinas
Publikováno v:
Scientifc Reports (2022) 12:21807
The study was partially funded by the ‘Accion Transversal del Cancer’, approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f74689b5c37b73ce3008f8868255fa6
https://hdl.handle.net/10481/79551
https://hdl.handle.net/10481/79551
Autor:
Jan-Stefan van der Walt, Joji Mori, Takahiro Nakayama, Kenichi Inoue, Yoshinori Ito, George W. Sledge, Yasuo Miyoshi, Tsutomu Kawaguchi, Masato Takahashi, Yoshinori Tanizawa, Masakazu Toi, Antonio Llombart-Cussac, Norikazu Masuda, Hiroji Iwata, Hirofumi Mukai, Sachi Sakaguchi
Publikováno v:
Breast Cancer (Tokyo, Japan)
Background This was a Japanese subpopulation analysis of MONARCH 2, a double-blind, randomized, placebo-controlled, phase 3 study of abemaciclib plus fulvestrant in patients with hormone receptor-positive, human epidermal growth factor receptor 2-neg
Publikováno v:
Journal of Human Genetics
Breast cancer is a heterogeneous disease that develops through a multistep process via the accumulation of genetic/epigenetic alterations in various cancer-related genes. Current treatment options for breast cancer patients include surgery, radiother
Publikováno v:
npj breast cancer
Breast cancer intrinsic subtypes (IS) are biologically distinct entities, characterized by specific natural gene expression patterns. The most widely accepted IS are the Luminal A, Luminal B, HER2-Enriched, and Basal-like (Fig. 1). These entities are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78db143a8d2117c1a71180bc436ca192
http://hdl.handle.net/2445/194395
http://hdl.handle.net/2445/194395
Autor:
Yokotani, Tomoyo, Ikeda, Naoya, Hirao, Tomoko, Tanaka, Yukimi, Morita, Kohei, Fujii, Tomomi, Ohbayashi, Chiho, Nakamura, Takashi, Kobayashi, Toyoki, Sho, Masayuki
Publikováno v:
Surgery today. 51(4):595-604
Purpose: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). Methods: The s
Autor:
Denis Le Bihan, Hiroyoshi Isoda, Masako Kataoka, Mami Iima, Yuji Nakamoto, Hirohiko Imai, Akihiko Yoshizawa, Yuko Someya
Publikováno v:
Scientific Reports. 12
We investigated the associations of time-dependent DWI, non-Gaussian DWI, and CEST parameters with histological biomarkers in a breast cancer xenograft model. 22 xenograft mice (7 MCF-7 and 15 MDA-MB-231) were scanned at 4 diffusion times [Td = 2.5/5
Autor:
Honkanen, T. J. (Tiia J.), Luukkainen, M. E. (Milla E. K.), Tikkanen, A. (Antti), Karihtala, P. (Peeter), Mäkinen, M. (Markus), Väyrynen, J. P. (Juha P.), Koivunen, J. P. (Jussi P.)
Purpose: Recent works have characterized that metastatic site can affect the tumour immune profiles and efficiency of cancer immunotherapies. The prognosis of HER2-positive breast cancer is associated with the characteristics of the tumour immune mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::85cad544f842d88d27228ac1399e83db
http://urn.fi/urn:nbn:fi-fe2022030922640
http://urn.fi/urn:nbn:fi-fe2022030922640
Publikováno v:
Br J Cancer
NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential scaffold for the assembly of a class of nuclear ribonucleoprotein bodies called p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bde762ce063b40b9e2f9019c14773ac
https://hdl.handle.net/10037/24685
https://hdl.handle.net/10037/24685