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Fresh Surgical Specimens Yield Breast Stem/Progenitor Cells and Reveal Their Oncogenic Abnormalities
Autor:
Ariel L. Hernandez, Jennifer A. Murphy, Rodney F. Pommier, Juliana E. Hansen, Patrick Muller, Arpana Naik, Esther Han, John T. Vetto, Brian S. Diggs, Su Ellen J. Pommier, Kristen P. Massimino, Erin Chamberlain
Publikováno v:
Annals of Surgical Oncology
Background The process by which breast cancer stem cells arise is unknown. It may be that the benign stem cells in breast tissue are transformed into malignant stem cells through the acquisition of genetic abnormalities. In this study, we collected a
Autor:
Heerma van Voss, Marise R., Schrijver, Willemijne A M E, Ter Hoeve, Natalie D., Hoefnagel, Laurien D., Manson, Quirine F., van der Wall, Elsken, Raman, Venu, van Diest, Paul J., Dutch Distant Breast Cancer Metastases Consortium, Distant Breast Cancer Metastases Consortium
Publikováno v:
Clinical & Experimental Metastasis, 34(1), 85–92. Springer Netherlands
Clinical & Experimental Metastasis, 34(1), 85-92. SPRINGER
Clinical & Experimental Metastasis
Clinical & Experimental Metastasis, 34(1), 85-92. SPRINGER
Clinical & Experimental Metastasis
Metastatic breast cancer remains one of the leading causes of death in women and identification of novel treatment targets is therefore warranted. Functional studies showed that the RNA helicase DDX3 promotes metastasis, but DDX3 expression was never
Autor:
Anieta M. Sieuwerts, J. Blom, Agnes Jager, Judith R. Kroep, John W.M. Martens, Caroline Seynaeve, Els M.J.J. Berns, J. Margriet Collée, Ans M.W. van den Ouweland, Mieke Kriege, Marion E. Meijer-van Gelder, Maartje J. Hooning, Antoinette Hollestelle
Publikováno v:
Journal of Cancer Research and Clinical Oncology, 141(10), 1879-1887. Springer-Verlag
Journal of Cancer Research and Clinical Oncology, 141(10), 1879-1887
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, 141(10), 1879-1887
Journal of Cancer Research and Clinical Oncology
Purpose The role of CHEK2 in DNA repair by homologous recombination suggests that CHEK2-associated breast cancer (BC) patients might be more sensitive to chemotherapy inducing double-strand DNA breaks, but results hereon are lacking. We compared the
Autor:
Clare, Robertson, Senthil Kumar Arcot, Ragupathy, Charles, Boachie, Cynthia, Fraser, Steve D, Heys, Graeme, Maclennan, Graham, Mowatt, Ruth E, Thomas, Fiona J, Gilbert, Robin, Wilson
Publikováno v:
European Radiology
To determine the diagnostic accuracy of surveillance mammography for detecting ipsilateral breast tumour recurrence and metachronous contralateral breast cancer in women previously treated for primary breast cancer.A systematic review of surveillance
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Most mammals develop their mammary glands in pairs of which the two counterparts are symmetrically displaced away from the ventral midline. Based on this symmetry and the same functional outcome as a milk-producing organ, the mammary glands are easil
Publikováno v:
Chinese Science Bulletin. 58(23):2805-2811
The main goal of this study was to investigate whether lidamycin (LDM) could enhance the efficacy of paclitaxel (TAX) against breast cancer. In the MTT assay, LDM showed much more potent cytotoxicity than paclitaxel, and there was a synergy on the 4T
Publikováno v:
Tumour Biology
The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk in the Chinese population has been widely reported, but results were inconsistent. In order to derive a more precise estimation of the relat
Autor:
Mariana Chavez-MacGregor, Carla H. van Gils, Petra H.M. Peeters, Paulus A. H. van Noord, Evelyn M. Monninkhof, Yvonne T. van der Schouw
Publikováno v:
Breast Cancer Research and Treatment
Objective Lifetime cumulative number of menstrual cycles is related to breast cancer risk. The aim of this study is to investigate the relation between this index and serum sex hormone levels in postmenopausal women. Methods Cross-sectional study inc
Publikováno v:
Breast Cancer (Tokyo, Japan)
Systemic therapies have been shown to effectively improve prognosis in patients with breast cancer. However, such therapies also become increasingly harmful as their duration increases, and they have adverse effects on fertility and ovarian function.
Autor:
Annele Sainio, Mikko Savontaus, Hannu Järveläinen, Tanja Kakko, Mirva Söderström, Pia Boström
Publikováno v:
Histochemistry and Cell Biology
The small extracellular matrix proteoglycan decorin which possesses a potent antitumor activity has been shown to be present in various amounts in the stroma of several tumors including those of the breast. Regarding decorin in breast malignancies th