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Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
Autor:
Sumana Sanyal, Fabien Thery, Wilson W. Ng, Andreas Damianou, Antje Beling, Hidde L. Ploegh, Adan Pinto-Fernandez, Chris Ka Pun Mok, Julian Ho, Lewis Yu Lam Siu, Horace Hok Yeung Lee, Deeksha Munnur, Francis Impens, Qi Wen Teo, Denzel Eggermont, Benedikt M. Kessler, Sophie Wilhelmina van Leur
Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) (ISG15) is a ubiquitin-like modifier induced during infections and involved in host defense mechanisms. Not surprisingly, many viruses encode deISGylating activities to antagonize its effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c350ea779304531b48d7fbc6decd67b
https://doi.org/10.1038/s41590-021-01035-8
https://doi.org/10.1038/s41590-021-01035-8
Autor:
Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos, Juan Carlos Acosta
Publikováno v:
Cell Death Differ . 2022 Jun;29(6):1267-1282
Fernández Duran, I, Quintanilla, A, Tarrats, N, Birch, J, Hari, P, Millar, F, Lagnado, A B, Smer Barreto, V, Muir, M, Brunton, V G, Passos, J F & Acosta, J-C 2021, ' Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence ', Cell Death & Differentiation (CDD) . https://doi.org/10.1038/s41418-021-00917-6
Fernández Duran, I, Quintanilla, A, Tarrats, N, Birch, J, Hari, P, Millar, F, Lagnado, A B, Smer Barreto, V, Muir, M, Brunton, V G, Passos, J F & Acosta, J-C 2021, ' Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence ', Cell Death & Differentiation (CDD) . https://doi.org/10.1038/s41418-021-00917-6
Cytoplasmic recognition of microbial lipopolysaccharides (LPS) in human cells is elicited by the caspase-4 and caspase-5 noncanonical inflammasomes, which induce a form of inflammatory cell death termed pyroptosis. Here we show that LPS-mediated acti
Autor:
Anuradhani Kasturiratne, Khadija I. Khawaja, Sajjad Ahmad, Samreen Siddiqui, Khurram Shahzad, Lathika K. Athauda, Ranil Jayawardena, Sara Mahmood, Mirthe Muilwijk, Tayyaba Batool, Saira Burney, Matthew Glover, Saranya Palaniswamy, Vodathi Bamunuarachchi, Manju Panda, Suren Madawanarachchi, Baldeesh Rai, Iqra Sattar, Wnurinham Silva, Swati Waghdhare, Marjo-Riitta Jarvelin, Ravindra P. Rannan-Eliya, Heather M. Gage, Irene G. M. van Valkengoed, Jonathan Valabhji, Gary S. Frost, Marie Loh, Ananda R. Wickremasinghe, Jaspal S. Kooner, Prasad Katulanda, Sujeet Jha, John C. Chambers
Publikováno v:
Kasturiratne, A, Khawaja, K I, Ahmad, S, Siddiqui, S, Shahzad, K, Athauda, L K, Jayawardena, R, Mahmood, S, Muilwijk, M, Batool, T, Burney, S, Glover, M, Palaniswamy, S, Bamunuarachchi, V, Panda, M, Madawanarachchi, S, Rai, B, Sattar, I, Silva, W, Waghdhare, S, Jarvelin, M R, Rannan-Eliya, R P, Gage, H M, van Valkengoed, I G M, Valabhji, J, Frost, G S, Loh, M, Wickremasinghe, A R, Kooner, J S, Katulanda, P, Jha, S & Chambers, J C 2021, ' The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes : study protocol for a randomised controlled trial ', Trials, vol. 22, no. 1, 928 . https://doi.org/10.1186/s13063-021-05803-7
Trials, 22(1):928. BioMed Central
Trials
Trials, Vol 22, Iss 1, Pp 1-13 (2021)
Trials, 22(1):928. BioMed Central
Trials
Trials, Vol 22, Iss 1, Pp 1-13 (2021)
Background People from South Asia are at increased risk of type 2 diabetes (T2D). There is an urgent need to develop approaches for the prevention of T2D in South Asians that are cost-effective, generalisable and scalable across settings. Hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad1a77e35f751e411eaa27f6f681aa6
https://bura.brunel.ac.uk/handle/2438/23917
https://bura.brunel.ac.uk/handle/2438/23917
Autor:
Tom Cadoux-Hudson, Ingvild Hvinden, Martine I. Abboud, James S. O. McCullagh, Tobias John, Shuang Liu, Victor A. Mikhailov, Ilaria Pettinati, Christopher J. Schofield, Xiao Liu, John Walsby-Tickle
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Cancer linked isocitrate dehydrogenase (IDH) 1 variants, notably R132H IDH1, manifest a ‘gain-of-function’ to reduce 2-oxoglutarate to 2-hydroxyglutarate. High-throughput screens have enabled clinically useful R132H IDH1 inhibitors, mostly allost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37dfb86cb4ae446c10b878b96d42cd9
https://doi.org/10.1038/s42003-021-02743-5
https://doi.org/10.1038/s42003-021-02743-5
Autor:
Martín-Alonso, Mara, Iqbal, Sharif, Vornewald, Pia M., Lindholm, Håvard T., Damen, Mirjam J., Martínez, Fernando, Hoel, Sigrid, Díez-Sánchez, Alberto, Altelaar, Maarten, Katajisto, Pekka, Arroyo, Alicia G., Oudhoff, Menno J., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
17 p.-8 fig.
Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells may have.
Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells may have.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b98826dca588121db8a83fd6e3dd47
http://hdl.handle.net/10261/256789
http://hdl.handle.net/10261/256789
Autor:
E. Bass, M. Winkler, Hashim U. Ahmed, A Pantovic, Ardeshir R. Rastinehad, Martin J. Connor, Rhian Gabe, Stacy Loeb
Publikováno v:
Prostate Cancer and Prostatic Diseases
Background Multiparametric MRI localizes cancer in the prostate, allowing for MRI guided biopsy (MRI-GB) 43 alongside transrectal ultrasound-guided systematic biopsy (TRUS-GB). Three MRI-GB approaches exist; visual estimation (COG-TB); fusion softwar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefd83ba403417a29a39c843ee6a7cba
http://rimi.imi.bg.ac.rs/bitstream/id/2517/Diagnostic_accuracy_of_magnetic_resonance_pub_2021.pdf
http://rimi.imi.bg.ac.rs/bitstream/id/2517/Diagnostic_accuracy_of_magnetic_resonance_pub_2021.pdf
Autor:
Sera, F., Armstrong, B., Abbott, S., Meakin, S., O’Reilly, K., von Borries, R., Schneider, R., Royé, D., Hashizume, M., Pascal, M., Tobias, A., Vicedo-Cabrera, A.M., Hu, W., Tong, S., Lavigne, E., Correa, P.M., Meng, X., Kan, H., Kynčl, J., Urban, A., Orru, H., Ryti, N.R.I., Jaakkola, J.J.K., Cauchemez, S., Dallavalle, M., Schneider, A., Zeka, A., Honda, Y., Ng, C.F.S., Alahmad, B., Rao, S., Di Ruscio, F., Carrasco Escobar, Gabriel, Seposo, X., Holobâcă, I.H., Kim, H., Lee, W., Íñiguez, C., Ragettli, M.S., Aleman, A., Colistro, V., Bell, M.L., Zanobetti, A., Schwartz, J., Dang, T.N., Scovronick, N., de Sousa Zanotti Stagliorio Coélho, M., Diaz, M.H., Zhang, Y., Russell, T.W., Koltai, M., Kucharski, A.J., Barnard, R.C., Quaife, M., Jarvis, C.I., Lei, J., Munday, J.D., Chan, Y.-W.D., Quilty, B.J., Eggo, R.M., Flasche, S., Foss, A.M., Clifford, S., Tully, D.C., Edmunds, W.J., Klepac, P., Brady, O., Krauer, F., Procter, S.R., Jombart, T., Rosello, A., Showering, A., Funk, S., Hellewell, J., Sun, F.Y., Endo, A., Williams, J., Gimma, A., Waterlow, N.R., Prem, K., Bosse, N.I., Gibbs, H.P., Atkins, K.E., Pearson, C.A.B., Jafari, Y., Villabona-Arenas, C.J., Jit, M., Nightingale, E.S., Davies, N.G., van Zandvoort, K., Liu, Y., Sandmann, F.G., Waites, W., Abbas, K., Medley, G., Knight, G.M., Gasparrini, A., Lowe, R., MCC Collaborative Research Network, CMMID COVID-19 Working Group
Publikováno v:
Nature Communications
NATURE COMMUNICATIONS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Sera, F, Armstrong, B, Abbott, S, Meakin, S, O’Reilly, K, von Borries, R, Schneider, R, Royé, D, Hashizume, M, Pascal, M, Tobias, A, Vicedo-Cabrera, A M & Gasparrini, A & Lowe, R 2021, ' A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries ', Nature Communications, vol. 12, no. 1, 5968 . https://doi.org/10.1038/s41467-021-25914-8
Nat. Commun. 12:5968 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sera, Francesco; Armstrong, Ben; Abbott, Sam; Meakin, Sophie; O'Reilly, Kathleen; von Borries, Rosa; Schneider, Rochelle; Royé, Dominic; Hashizume, Masahiro; Pascal, Mathilde; Tobias, Aurelio; Vicedo-Cabrera, Ana Maria; Gasparrini, Antonio; Lowe, Rachel (2021). A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries. Nature communications, 12(1), p. 5968. Nature Publishing Group 10.1038/s41467-021-25914-8
NATURE COMMUNICATIONS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Sera, F, Armstrong, B, Abbott, S, Meakin, S, O’Reilly, K, von Borries, R, Schneider, R, Royé, D, Hashizume, M, Pascal, M, Tobias, A, Vicedo-Cabrera, A M & Gasparrini, A & Lowe, R 2021, ' A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries ', Nature Communications, vol. 12, no. 1, 5968 . https://doi.org/10.1038/s41467-021-25914-8
Nat. Commun. 12:5968 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sera, Francesco; Armstrong, Ben; Abbott, Sam; Meakin, Sophie; O'Reilly, Kathleen; von Borries, Rosa; Schneider, Rochelle; Royé, Dominic; Hashizume, Masahiro; Pascal, Mathilde; Tobias, Aurelio; Vicedo-Cabrera, Ana Maria; Gasparrini, Antonio; Lowe, Rachel (2021). A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries. Nature communications, 12(1), p. 5968. Nature Publishing Group 10.1038/s41467-021-25914-8
There is conflicting evidence on the influence of weather on COVID-19 transmission. Our aim is to estimate weather-dependent signatures in the early phase of the pandemic, while controlling for socio-economic factors and non-pharmaceutical interventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4056072279bdc525af1d1bee7b52214
https://bura.brunel.ac.uk/handle/2438/23329
https://bura.brunel.ac.uk/handle/2438/23329
Autor:
Desirée Spronk, Alexander Luettich, Rufus Corkill, Catherine Lamb, Martyn Ezra, Kyle T.S. Pattinson, Jash Patel, Edit Frankó
Subarachnoid haemorrhage (SAH) is associated with long-term disability, serious reduction in quality of life and significant mortality. Early brain injury (EBI) refers to the pathological changes in cerebral metabolism and blood flow that happen in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5d14bee5cee8dc87f6ffdb6a47b16b
https://doi.org/10.1007/s12975-021-00939-9
https://doi.org/10.1007/s12975-021-00939-9
Autor:
Ina Balke, Kaspars Tars, Said Dermime, Mona O. Mohsen, Martin F. Bachmann, Zahra Gharailoo, Andris Zeltins, Monique Vogel, Gheyath K. Nasrallah, Byron E. E. Martina, Dominik Rothen, Varghese Inchakalody, Vilija Zeltina
Publikováno v:
npj Vaccines, 6(1):107. Nature Publishing Group
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Mohsen, Mona O.; Rothen, Dominik; Balke, Ina; Martina, Byron; Zeltina, Vilija; Inchakalody, Varghese; Gharailoo, Zahra; Nasrallah, Gheyath; Dermime, Said; Tars, Kaspars; Vogel, Monique; Zeltins, Andris; Bachmann, Martin F. (2021). Neutralization of MERS coronavirus through a scalable nanoparticle vaccine. NPJ vaccines, 6(1), p. 107. Springer Nature 10.1038/s41541-021-00365-w
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Mohsen, Mona O.; Rothen, Dominik; Balke, Ina; Martina, Byron; Zeltina, Vilija; Inchakalody, Varghese; Gharailoo, Zahra; Nasrallah, Gheyath; Dermime, Said; Tars, Kaspars; Vogel, Monique; Zeltins, Andris; Bachmann, Martin F. (2021). Neutralization of MERS coronavirus through a scalable nanoparticle vaccine. NPJ vaccines, 6(1), p. 107. Springer Nature 10.1038/s41541-021-00365-w
MERS-CoV continues to cause human outbreaks, so far in 27 countries worldwide following the first registered epidemic in Saudi Arabia in 2012. In this study, we produced a nanovaccine based on virus-like particles (VLPs). VLPs are safe vaccine platfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a45e168fb3ae3c92c61bc019e7215a
https://hdl.handle.net/10576/23003
https://hdl.handle.net/10576/23003
Autor:
Ivan Ahel, John Brognard, Evgeniia Prokhorova, Alessandra Peters, Ian Gibbs-Seymour, Sébastien Huet, Siham Zentout, Florian Zobel, Rebecca Smith, Valentina Zorzini, Thomas Agnew, Kira Schützenhofer, Marcin J. Suskiewicz, Joséphine Groslambert, Michael L. Nielsen, Dragana Ahel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Nature Communications, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, M L, Ahel, D, Huet, S, Suskiewicz, M J & Ahel, I 2021, ' Serine-linked PARP1 auto-modification controls PARP inhibitor response ', Nature Communications, vol. 12, no. 1, 4055 . https://doi.org/10.1038/s41467-021-24361-9
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Nature Communications, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, M L, Ahel, D, Huet, S, Suskiewicz, M J & Ahel, I 2021, ' Serine-linked PARP1 auto-modification controls PARP inhibitor response ', Nature Communications, vol. 12, no. 1, 4055 . https://doi.org/10.1038/s41467-021-24361-9
Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself and in other proteins. Several PARP1 and PARP2 inhibitors are currently employed in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23a9429d24efc41f73633abb3451ab8
https://doi.org/10.1038/s41467-021-24361-9
https://doi.org/10.1038/s41467-021-24361-9