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Publikováno v:
International Journal of Oncology. 62
With the development of precision medicine, targeted therapy has attracted extensive attention. Poly(ADP‑ribose) polymerase inhibitors (PARPi) are critical clinical drugs designed to induce cell death and are major antitumor targeted agents. Howeve
Publikováno v:
Molecular Medicine Reports. 27
The mechanism underlying bladder cancer metastasis is associated with tumor angiogenesis. The present study aimed to evaluate the predictive role and value of an angiogenesis‑associated long non‑coding (lnc)RNA signature in patients with bladder
Autor:
Bing, Jiang, Longfei, Feng, Tao, Yang, Wenjing, Guo, Yangyang, Li, Tao, Wang, Chengguang, Liu, Haixiang, Su
Publikováno v:
Molecular Medicine Reports. 27
Hepatocellular carcinoma (HCC) is the leading cause of cancer‑associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic suc
Publikováno v:
International Journal of Oncology. 62
Genetic alterations drive tumor onset and progression. However, the cross‑talk between tumor cells and the benign components of the surrounding stroma can also promote the initiation, progression and metastasis of solid tumors. These cellular and n
Autor:
Yue Qiu, Zeng Qi, Zhaohui Wang, Yu Cao, Ling Lu, Huiping Zhang, David Mathes, Elizabeth Pomfret, Shi-Long Lu, Zhirui Wang
Publikováno v:
Oncology Reports. 49
The epidermal growth factor receptor (EGFR) remains one of the best molecules for developing targeted therapy for multiple human malignancies, including head and neck squamous cell carcinoma (HNSCC). Small molecule inhibitors or antibodies targeting
Publikováno v:
Molecular Medicine Reports. 27
Premature ovarian insufficiency (POI) is a common clinical disease of the reproductive system in which patients lose normal gonadal function prior to the age of 40. Common pathogenic factors include iatrogenic injury, genetics, inflammation, autoimmu
Publikováno v:
Molecular Medicine Reports. 27
Ras‑related C3 botulinum toxin substrate 1 (RAC1), a member of the Rac family of guanosine triphosphate phosphohydrolases, has been suggested to be a regulator of myocardial injury during ischemia and reperfusion (I/R). Whether microRNAs (miRs) are
Autor:
Anja, Lindemann, Florian, Brandes, Melanie, Borrmann, Agnes S, Meidert, Benedikt, Kirchner, Ortrud K, Steinlein, Gustav, Schelling, Michael W, Pfaffl, Marlene, Reithmair
Publikováno v:
Oncology Reports. 49
Prometastatic and antitumor effects of different anesthetics have been previously analyzed in several studies with conflicting results. Thus, the underlying perioperative molecular mechanisms mediated by anesthetics potentially affecting tumor phenot
Publikováno v:
International Journal of Oncology. 62
Lung cancer is one of the most common malignant tumor types and the leading cause of cancer‑associated death worldwide. Different types of lung cancer exhibit differences in terms of pathophysiology and pathogenesis, and also treatment and prognosi
Publikováno v:
Molecular Medicine Reports. 27
The function of human dicarbonyl/L‑xylulose reductase (DCXR) in the pathophysiology of breast cancer is yet to be elucidated. The present study aimed to investigate the function of DCXR in glycolysis and the cell cycle of breast cancer cells with r