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Publikováno v:
Oncology Reports
Activated epidermal growth factor receptors (EGFRs) are crucial for inducing metastasis in cancer cells by promoting matrix metalloproteinase (MMP) expression. The present study was designed to investigate the effects of 1‑palmitoyl‑2‑linoleoyl
Publikováno v:
Oncology Reports
Type 2 diabetes increases the risk various types of cancer and is associated with a poor prognosis therein. There is also evidence that the disease is associated with cancer metastasis. Centrosome amplification can initiate tumorigenesis with metasta
Publikováno v:
Oncology Reports. 46
Inability of early detection as well as lack of proper therapeutic intervention, both add to the complexity of pancreatic cancer. Understanding of the basic cellular processes is of the utmost importance and autophagy is one of these processes. Consi
Publikováno v:
Oncology Reports
Alternative splicing (AS) occurs in nearly all human genes and abnormal AS has a close association with cancer. Serine and arginine-rich splicing factor 6 (SRSF6), a canonical member of the serine/arginine-rich protein family, has been characterized
Autor:
Zvi Fishelson, Osnat Bairey, Ritta Jubran, Natalie Donin, Moran Saar-Ray, Anna Wawruszak, Lea Ziporen
Publikováno v:
International Journal of Oncology.
Cancer cells have developed numerous strategies to maintain their proliferative capacity and to withstand different kinds of stress. The mitochondrial stress‑70 protein named glucose regulated protein 75 (GRP75), also known as mortalin, is an intri
Autor:
Stefanie Engleitner, Daniela Milovanovic, Nathalie Ropek, Georg Krupitza, Walter Jäger, Rainer de Martin, Kerstin Kirisits, Junli Hong, Nicole Huttary, Judith Rehak, Chi Huu Nguyen, Stefan Brenner, Zsuzsanna Bago-Horvath, Siegfried Knasmüller
Publikováno v:
International Journal of Oncology.
Metastatic cancer cells cross endothelial barriers and travel through the blood or lymphatic fluid to pre‑metastatic niches, leading to their colonisation. 'S' stereoisomer 12S‑hydroxy‑5Z,8Z,10E,14Z‑eicosatetraenoic acid [12(S)‑HETE] is sec
Publikováno v:
Oncology Reports
It has been reported recently that bradykinin (BK) is involved in the regulation of various processes in cancer cells. However, its role and underlying mechanism of action in cervical cancer (CC) are still unknown. In the present study, it was reveal
Autor:
Ming Jen Fan, Fu Shin Chueh, Rick Sai-Chuen Wu, Han‑Yu Chou, Wen Wen Huang, Yi Shih Ma, Jing Gung Chung, Ching Lung Liao, Yung Lin Chu
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the cytotoxic effects of bufalin on SCC-4 human tongue cancer cells. Cell morphological changes and viability were examined using phase contrast microscopy and flow cytometry, respectively. The results
Autor:
Xiaolu Li, Li-Xiao Xu, Xiaolan Chen, Wei-Wei Du, Guang-Hui Qian, Chun Yang, Yi Wu, Jian Wang, Shaoyan Hu, He Zhao, Jian Pan, Fang Fang, Jun Lu, Xin Ding, Junli Ren, Zhi-Heng Li, Mei Li, Yunyun Xu, Yan-Fang Tao
Publikováno v:
Oncology Reports
Neuroblastoma is the most common extracranial solid childhood tumor. Despite the availability of advanced multimodal therapy, high-risk patients still have low survival rates. p21-activated kinase 4 (PAK4) has been shown to regulate many cellular pro
Autor:
Makiko Nakahana, Takashi Sasayama, Mohammed Salah, Ryo Nishikawa, Naritoshi Mukumoto, Sachiko Inubushi, Daisuke Miyawaki, Takeaki Ishihara, Yoshiko Fujita, Mennaallah Hassan, Hiroaki Akasaka, Hikaru Kubota, Ryohei Sasaki, Ai Nakaoka
Publikováno v:
Oncology Reports
The precise mechanism of intercellular communication between cancer cells following radiation exposure is unclear. Exosomes are membrane‑enclosed small vesicles comprising lipid bilayers and are mediators of intercellular communication that transpo