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Autor:
Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010010 (2022)
PLoS Genetics
PLoS Genetics
Calcific aortic valve disease (CAVD) is characterized by a fibrocalcific process. The regulatory mechanisms that drive the fibrotic response in the aortic valve (AV) are poorly understood. Long noncoding RNAs derived from super-enhancers (lncRNA-SE)
Publikováno v:
PLoS Genetics, Vol 18, Iss 1 (2022)
PLoS Genetics, Vol 18, Iss 1, p e1009996 (2022)
PLoS Genetics
PLoS Genetics, Vol 18, Iss 1, p e1009996 (2022)
PLoS Genetics
There is a growing need to develop novel therapeutics for targeted treatment of cancer. The prerequisite to success is the knowledge about which types of molecular alterations are predominantly driving tumorigenesis. To shed light onto this subject,
Autor:
Shu Ching Yang, Nan Haw Chow, Hung Wen Tsai, Yi Lin Chen, Wan Li Chen, Yi Chia Cheng, Ming Ching Lin, Chung Liang Ho, Wu Chou Su, Chien Chung Lin
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257152 (2021)
PLoS ONE
PLoS ONE
Approximately 5–7% of non–small cell lung cancer (NSCLC) cases harbor an anaplastic lymphoma kinase (ALK) fusion gene and may benefit from ALK inhibitor therapy. To detect ALK fusion genes, we developed a novel test using reverse transcription po
Autor:
Ashok Prabhu, Judith Huettemeister, Leif-Hendrik Boldt, Sandra C. Klaucke, Frank R. Heinzel, Philipp Lacour, Florian Blaschke, Abdul Shokor Parwani, Lars Bullinger, Sanzio Dimai, Harald Stachelscheid, Felix Hohendanner, Jan Kruse, Burkert Pieske, Lukas Semmler
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255976 (2021)
PLoS ONE
PLoS ONE
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for
Autor:
Kyoung Min Moon, Mi Jung Kwon, Young Wha Koh, Il Hwan Oh, Intazur Rahaman, Eun Kyung Kim, Kyueng-Whan Min, So Myoung Kim, So Won Kim, Byoung Kwan Son, Dong-Hoon Kim
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245075 (2021)
PLoS ONE
PLoS ONE
High expression of glucose transporter family members, which augment glucose uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation and survival of tumor cells, contributing to the energy supply, biosynthesis and homeo
Autor:
D L Rotin, Daria M. Potashnikova, Wilma A. Hofmann, Grigoriy V. Knyshinsky, Evgeniy I. Veliev, Ivan A. Vorobjev, Aleena A. Saidova, Ivan V. Maly, Oxana V. Paklina, Galiya R. Setdikova, Anna V. Tvorogova
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251961 (2021)
PLoS ONE
PLoS ONE
Early diagnosis of prostate cancer is a challenging issue due to the lack of specific markers. Therefore, a sensitive diagnostic marker that is expressed or upregulated exclusively in prostate cancer cells would facilitate diagnostic procedures and e
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253112 (2021)
PLoS ONE
PLoS ONE
The chronic inflammation influences a microenvironment, where as a result of losing control over tissue homeostatic mechanisms, the carcinogenesis process may be induced. Inflammatory response cells can secrete a number of factors that support both i
Autor:
Lizhu Lin, Leihao Hu, Wei Guo, Cai-Zhi Yang, Jietao Lin, Shan Liu, Zhong-Yu Huang, Li Deng, Hong-Xing Yang, Xi Xiao, Lingling Sun
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260720 (2021)
PLoS ONE
PLoS ONE
Globally, non-small cell lung cancer (NSCLC) is the most common malignancy and its prognosis remains poor because of the lack of reliable early diagnostic biomarkers. The competitive endogenous RNA (ceRNA) network plays an important role in the tumor
Autor:
Dennis J. Ahnen, Angela N. Bartley, Wei Wei, Ajay Goel, Elizabeth L. Barry, Robert S. Bresalier, Michael N. Passarelli, Gail McKeown-Eyssen, Trupti R. Mehta, Stanley R. Hamilton, John A. Baron, Lynda J. Corley, Goretti Hernández Mesa, Jeffrey S. Morris, Jane C. Figueiredo
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0258878 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
Background Adenomas and serrated lesions represent heterogeneous sets of early precursors in the colorectum with varying malignant potential. They are often distinguished by their histopathologic differences, but little is known about potential diffe
Autor:
Krisztina Schlachter, András Kiss, Gábor Lotz, Ildikó Illyés, Milán Csengeri, Gábor Lendvai, Katalin Borka, Zsuzsa Schaff, Tímea Szekerczés, Erzsébet Szabó
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253065 (2021)
PLoS ONE
PLoS ONE
The presence of autophagy has been indicated in cholangiocarcinoma (CC), which disease has poor prognosis and limited treatment options. Recently, CC has been classified by anatomical localization as intrahepatic (iCC), perihilar (pCC) and distal (dC