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Autor:
Akos Gyenis, Jiang Chang, Joris J. P. G. Demmers, Serena T. Bruens, Sander Barnhoorn, Renata M. C. Brandt, Marjolein P. Baar, Marko Raseta, Kasper W. J. Derks, Jan H. J. Hoeijmakers, Joris Pothof
Publikováno v:
Nature Genetics, 55(2), 268-279. Nature Publishing Group
Gene expression profiling has identified numerous processes altered in aging, but how these changes arise is largely unknown. Here we combined nascent RNA sequencing and RNA polymerase II chromatin immunoprecipitation followed by sequencing to elucid
Publikováno v:
Nature Communications. 14:1-3
Autor:
Crossley, Magdalena P., Song, Chenlin, Bocek, Michael J., Choi, Jun Hyuk, Kousorous, Joseph, Sathirachinda, Ataya, Lin, Cindy, Brickner, Joshua R., Bai, Gongshi, Lans, Hannes, Vermeulen, Wim, Abu-Remaileh, Monther, Cimprich, Karlene A., Kanaar, Roland
Publikováno v:
Nature, 613(7942), 187-194. Nature Publishing Group
Nature
Nature
R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability1, which has been linked to the action of endonucleases such as XPG2–4. However, the m
Autor:
Jim Li, Gerhard Frick, Karel Herberigs, Paul Matsumura, Josh Sarkis, Willem J. Verberk, Caryl Wojcik
Publikováno v:
Journal of Human Hypertension, 37, 130-133. Nature Publishing Group
A group of experts from reputable blood pressure measuring device (BPMD) manufacturers was invited to provide industry perspectives on the global use of validated BPMD. The authors support the recommendations of (1) using the consolidated universal I
Autor:
Luca M. Zaeck, Mart M. Lamers, Babs E. Verstrepen, Theo M. Bestebroer, Martin E. van Royen, Hannelore Götz, Marc C. Shamier, Leanne P. M. van Leeuwen, Katharina S. Schmitz, Kimberley Alblas, Suzanne van Efferen, Susanne Bogers, Sandra Scherbeijn, Guus F. Rimmelzwaan, Eric C. M. van Gorp, Marion P. G. Koopmans, Bart L. Haagmans, Corine H. GeurtsvanKessel, Rory D. de Vries
Publikováno v:
Nature Medicine, 29(1), 270-278. Nature Publishing Group
medRxiv
Nature Medicine
medRxiv
Nature Medicine
In July 2022, the ongoing monkeypox (MPX) outbreak was declared a public health emergency of international concern by the World Health Organization. Modified vaccinia virus Ankara (MVA-BN, also known as Imvamune, Jynneos, or Imvanex) is a 3rd generat
Autor:
Elisabeth Bakker, Kelly Plueschke, Carla J. Jonker, Xavier Kurz, Viktoriia Starokozhko, Peter G. M. Mol
Publikováno v:
Clinical Pharmacology & Therapeutics, 113(1), 135-151. Nature Publishing Group
Real-world data/evidence (RWD/RWE) may provide insightful information on medicines' clinical effects to guide regulatory decisions. While its contribution has been recognized for safety monitoring and disease epidemiology across medicines' life cycle
Autor:
Romina Willi, Mario Widmer, Nora Merz, Caroline H. G. Bastiaenen, Björn Zörner, Marc Bolliger
Publikováno v:
Spinal Cord, 61(1), 15-21. Nature Publishing Group
Study design Multicentre-observational study. Objectives The 6-minute walk test (6mWT) is an established assessment of walking function in individuals with spinal cord injury (SCI). However, walking 6 min can be demanding for severely impaired indivi
Publikováno v:
Molecular Psychiatry. :28-33
Many psychiatric and neurological disorders present deficits in both the social and cognitive domain. In this perspectives article, we provide an overview and the potential of the existence of an extensive neurobiological substrate underlying the clo
Publikováno v:
European Journal of Human Genetics. 31(1):55-72
Carrier screening aims to identify couples at risk of conceiving children with a recessive condition. Until recently, carrier screening was primarily offered ancestry-based. Technological advances now facilitate expanded universal carrier screening (
Autor:
Lei Fan, Jean-Pierre Wigneron, Philippe Ciais, Jérome Chave, Martin Brandt, Stephen Sitch, Chao Yue, Ana Bastos, Xin Li, Yuanwei Qin, Wenping Yuan, Dmitry Schepaschenko, Liudmila Mukhortova, Xiaojun Li, Xiangzhuo Liu, Mengjia Wang, Frédéric Frappart, Xiangming Xiao, Jingming Chen, Mingguo Ma, Jianguang Wen, Xiuzhi Chen, Hui Yang, Dave van Wees, Rasmus Fensholt
Publikováno v:
Fan, L, Wigneron, J P, Ciais, P, Chave, J, Brandt, M, Sitch, S, Yue, C, Bastos, A, Li, X, Qin, Y, Yuan, W, Schepaschenko, D, Mukhortova, L, Li, X, Liu, X, Wang, M, Frappart, F, Xiao, X, Chen, J, Ma, M, Wen, J, Chen, X, Yang, H, van Wees, D & Fensholt, R 2023, ' Siberian carbon sink reduced by forest disturbances ', Nature Geoscience, vol. 16, pp. 56–62 . https://doi.org/10.1038/s41561-022-01087-x
Nature Geoscience
Fan, L, Wigneron, J P, Ciais, P, Chave, J, Brandt, M, Sitch, S, Yue, C, Bastos, A, Li, X, Qin, Y, Yuan, W, Schepaschenko, D, Mukhortova, L, Li, X, Liu, X, Wang, M, Frappart, F, Xiao, X, Chen, J, Ma, M, Wen, J, Chen, X, Yang, H, van Wees, D & Fensholt, R 2023, ' Siberian carbon sink reduced by forest disturbances ', Nature Geoscience, vol. 16, no. 1, pp. 56-62 . https://doi.org/10.1038/s41561-022-01087-x
Nature Geoscience, 2023, 16, pp.56-62. ⟨10.1038/s41561-022-01087-x⟩
Nature Geoscience, 16(1), 56-62. Nature Publishing Group
Nature Geoscience
Fan, L, Wigneron, J P, Ciais, P, Chave, J, Brandt, M, Sitch, S, Yue, C, Bastos, A, Li, X, Qin, Y, Yuan, W, Schepaschenko, D, Mukhortova, L, Li, X, Liu, X, Wang, M, Frappart, F, Xiao, X, Chen, J, Ma, M, Wen, J, Chen, X, Yang, H, van Wees, D & Fensholt, R 2023, ' Siberian carbon sink reduced by forest disturbances ', Nature Geoscience, vol. 16, no. 1, pp. 56-62 . https://doi.org/10.1038/s41561-022-01087-x
Nature Geoscience, 2023, 16, pp.56-62. ⟨10.1038/s41561-022-01087-x⟩
Nature Geoscience, 16(1), 56-62. Nature Publishing Group
International audience; Siberian forests are generally thought to have acted as an important carbon sink over recent decades, but exposure to severe droughts and fire disturbances may have impacted their carbon dynamics. Limited available forest inve