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Autor:
Hui Liang, Yu-Ling Li, Li Jing, Jun-Xu Li, Zheng Yong, Yan-Ting Wang, Qing Liu, Qi Gong, Jian-Hui Liang, Shoupeng Wei, Min Zhang, Andrew J Lawrence
Brucine (BRU) extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmacodynamic profiles and adverse effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eb0e6dea75271eac04106e21bc5c05
https://europepmc.org/articles/PMC4088279/
https://europepmc.org/articles/PMC4088279/
Autor:
Norman G. Bowery, Gerard D. Pratt
1. GABAB receptor binding site densities within laminar regions of the rat frontal cortex were examined autoradiographically following repeated administration (21 days) of the antidepressants desipramine, paroxetine and amitriptyline in addition to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3e9ca9a80f20708548b5ef536ea87d
https://europepmc.org/articles/PMC2175914/
https://europepmc.org/articles/PMC2175914/
1 Male Wistar rats were treated neonatally with guanethidine (following a protocol reported to produce a permanent peripheral sympathectomy) and the extent of the sympathectomy was assessed when the rats were mature. 2 The noradrenaline content of ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c22b3fa1edf2878ac8afcb7067823c
https://europepmc.org/articles/PMC2071825/
https://europepmc.org/articles/PMC2071825/
Autor:
P. Quinn, K.R. Borkowski
Bilateral adrenal demedullation of juvenile spontaneously hypertensive rats attenuated, but did not prevent, the development of hypertension. Neither did it affect the subsequent vascular reactivity to phenylephrine though it significantly reduced th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e6ef015865bcb47a806915a8b210d4
https://europepmc.org/articles/PMC2045004/
https://europepmc.org/articles/PMC2045004/
Autor:
Douglas W. P. Hay, Roger M. Wadsworth
The effects of KCl 160 mM on 45Ca uptake and efflux in the rat isolated vas deferens were investigated using a modification of the lanthanum method and a superfusion system respectively. In the prostatic half, basal cellular 45Ca uptake was 679 +/- 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0349c0f084f96c0dcab14f3f2ed43c
https://europepmc.org/articles/PMC1986861/
https://europepmc.org/articles/PMC1986861/
Rat and rabbit kidneys were isolated, perfused via the renal artery with Krebs solution and perfusion pressure monitored. Dose-response curves to noradrenaline administered as bolus doses or frequency-response curves from transmural arterial electric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5d2b6521063d091cc3bb0ba3582195
https://europepmc.org/articles/PMC1987248/
https://europepmc.org/articles/PMC1987248/
The effect of the imidazolidine Sgd 101/75 (2-[2-methylindazol-4-imino]-imidazolidine HCl) on blood pressure, as well as its alpha-adrenoceptor agonist activity and affinity for these receptors, were examined in various animal preparations. After bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166116b83c257a57b2c4e54bb3142bd2
https://europepmc.org/articles/PMC1986886/
https://europepmc.org/articles/PMC1986886/
Autonomic and cardiovascular function were assessed in rats with glycerol-induced acute renal failure (ARF). Rats with ARF had significantly lower mean arterial blood pressure and heart rates and significantly elevated plasma noradrenaline concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d60b7fe2a9f278548d87df3ad9f024
https://europepmc.org/articles/PMC2044854/
https://europepmc.org/articles/PMC2044854/
The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767b41c0ee3f9e309919de2c278abc84
https://europepmc.org/articles/PMC1986880/
https://europepmc.org/articles/PMC1986880/
Autor:
Valerio Borzatta, Stefania Geminiani, A M Morselli, Giuseppe Mascellani, Enrico Roda, Aldo Roda, Luigi Barbara, Rita Aldini, Augusta Benelli
1 Hypolipidaemic agents may increase biliary cholesterol in man, inducing a supersaturated bile. 2 To evaluate this possible side-effect, we have studied bile lipid secretion over a period of 8 h with intact enterohepatic circulation and 4 h with com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b774541cb687389679aa747db288b91
https://europepmc.org/articles/PMC2071745/
https://europepmc.org/articles/PMC2071745/