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Autor:
Sadaf Soloukey, Andreas Rowald, Claudia Kathe, Ivan Furfaro, Philipp Schonle, Valentina Paggi, Quentin Barraud, Stéphanie P. Lacour, Jimmy Ravier, Qiuting Huang, Kyungjin Kim, Thomas H. Hutson, Ileana O. Jelescu, Antoine Philippides, Noaf Salah Ali Alwahab, Chris I. De Zeeuw, Daniel Huber, Frédéric Michoud, Leonie Asboth, Noe Brun, Jerome Gandar, Grégoire Courtine
Publikováno v:
Nature Biotechnology, 40 (2)
Nature Biotechnology, 40(2), 198-208. Nature Publishing Group
Nature Biotechnology, 40, 198-208. Nature Publishing Group
Nature Biotechnology, 40(2), 198-208. Nature Publishing Group
Nature Biotechnology, 40, 198-208. Nature Publishing Group
Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultr
Autor:
Aleksandra Sobiborowicz, Dominika Nowis, Paweł Jabłoński, Agnieszka Borowiec, Anna A Marusiak, Alicja Mazan, Monika K. Prelowska, Dawid Mehlich, Adam Gorczyński, Ewa Iżycka-Świeszewska, Michał Łomiak, Łukasz M. Szewczyk, Dagmara Dymerska, Anna Mehlich
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential
Autor:
Yuan-Ting Kuo, Kai-Ti Lin, Yi-Hsiang Wang, Wen-Hung Kuo, Chia-Yi Shen, Lu-Hai Wang, Wen-Ching Wang, Yu-Ling Hsu, Sheng-Chieh Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast ca
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Autor:
Shenshen Wu, Xiaobo Li, Xinwei Zhang, Haitao Zhu, Qingtao Meng, Michael Aschner, Michela Relucenti, Bin Li, Jun Yun, Rui Chen, Jie Xu, Hongbao Yang, Giuseppe Familiari, Hao Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients f
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Melanoma originates from melanin-producing cells called melanocytes. Melanoma poses a great risk because of its rapid ability to spread and invade new organs. Cellular metastasis involves alteration in the gene expression profile and their transforma
Autor:
Li-Yun Gong, Xing-Xuan Wu, Guan-Zi Chen, Jing Zhu, Li-Yin Liang, Jing-Qiang Huang, Ting Tu, Jun-Wei Song, Chun-Hui Zhou, XingZhi Xu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largely unknown. Golgi phosphoprotein 3 (GOLPH3
Autor:
Xiangkai Zhang, Shuli Liu, Jiong Deng, Yong Han, Liu Liu, Yang Wang, Shengming Xu, Zhiyuan Zhang, Weimin Ye
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor with poor clinical outcomes due to recurrence, metastasis, and treatment resistance. Cancer stem cells (CSCs), a small population among tumor cells, are proposed to be respons
Autor:
Sandra Orozco-Suárez, Norma Oviedo, Minerva Crespo Ramírez, Leticia Manuel-Apolinar, Miguel Pérez de la Mora, Vilma Carolina Bekker-Méndez, Vladimir Paredes-Cervantes, Emiliano Tesoro-Cruz, Sandra Angélica Rojas-Osornio, M. Magdalena Aguirre-García
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Translational Psychiatry
Translational Psychiatry
Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. In the la
Autor:
Xiuying Li, Tiao Li, Seyed Mehdi Nouraie, Janet S. Lee, Kong Chen, Georgios D Kitsios, Rama K. Mallampalli, Bryan J. McVerry, Yingze Zhang, Yandong Lai, Chunbin Zou, Toru Nyunoya
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Lung epithelial cell death is a prominent feature of acute lung injury and acute respiratory distress syndrome (ALI/ARDS), which results from severe pulmonary infection leading to respiratory failure. Multiple mechanisms are believed to contribute to
Autor:
Hillary Protas, Dimitri Avramopoulos, Kewei Chen, Eric M. Reiman, Gwenn S. Smith, Jin Hui Joo, Alena Savonenko, Yi Su, Neda F Gould, Ayon Nandi, Hiroto Kuwabara, Clifford I. Workman, Michael A. Kraut
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodegenerative mechanisms that are common to de