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Autor:
Tong Shen, Youlutuziayi Rixiati, Ling-Dong Cai, Jian-Ming Li, Jing-Lin Liu, Chu-Yi Wang, Yuan-Yuan Zhao, Shi Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-18 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The mechanisms and key factors involved in tumor environments for lung metastasis of CRC are still unclear. Here, using clinical samples from lung metastases of CRC patients, we found that intestinal immune network for IgA production was significantl
Autor:
Changsheng Xu, Renqi Li, Shanwu Feng, Xian Wang, Shaolei Ma, Mingjie Mao, Xiaodi Sun, Shijiang Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-7 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The benefits and harms of corticosteroids for patients with severe coronavirus disease 2019 (COVID-19) remain unclear. We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials from December 31, 2019 to October 1,
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-6 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
In response to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, over 200 vaccine candidates against coronavirus disease 2019 (COVID-2019) are under development and currently moving forward at an unparalleled speed. The avail
Autor:
Xiaofei Zhou, Shao Cong Sun
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Cancer immunotherapy has become an attractive approach of cancer treatment with tremendous success in treating various advanced malignancies. The development and clinical application of immune checkpoint inhibitors represent one of the most extraordi
Autor:
Nissar A. Wani, Parvaiz Yousuf, Ajaz A. Bhat, Surinder K. Batra, Shyam S. Chauhan, Mohammad Haris, Davide Bedognetti, Mushtaq A. Siddiqi, Muzafar A. Macha, Arshi Rizwan, Wael El-Rifai, Michael P. Frenneaux
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. D
Autor:
Xiangjian Luo, Min Tang, Jianmin Hu, Luqing Zhao, Xinfang Yu, Lin Zhao, Weihua Liao, Longlong Xie, Yueshuo Li, Feng Shi, Ya Cao, Ann M. Bode
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-33 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Epstein–Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Moreover, EBV plays an etiological and pat
Autor:
Yan Gao, Jun Cai, Yi Xia, Qingqing Cai, Shuyun Ma, Yuchen Zhang, Lirong Li, Xiaopeng Tian, Hang Yang, Panpan Liu, Yajun Li, Xuanye Zhang, Hui Zhou, Huiqiang Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-9 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Advanced natural killer/T cell lymphoma (NKTL) has demonstrated poor prognosis with currently available therapies. Here, we report the efficacy of anti-programmed death 1 (PD-1) antibody with the P-GEMOX (pegaspargase, gemcitabine, and oxaliplatin) r
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-15 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Fulminant myocarditis (FM) is characterized by a rapid progressive decline in cardiac function and a high mortality rate. Since the first report of FM patients in the 1980s, several clinical trials and research studies have been published increasing
Autor:
Michael Nilsson, Lin Kooi Ong, Murielle G. Kluge, Wei Zhen Chow, Frederick R. Walker, Prajwal Gyawali
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
For many chronic stroke survivors, persisting cognitive dysfunction leads to significantly reduced quality of life. Translation of promising therapeutic strategies aimed at improving cognitive function is hampered by existing, disparate cognitive ass
Autor:
John Patrick Aggleton, Emma Jane Kidd, Jilu P. Mole, John Evans, Claudia Metzler-Baddeley, Fabrizio Fasano, Rebecca Sims
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-25 (2020)
Scientific Reports
Scientific Reports
APOE-ε4 is a main genetic risk factor for developing late onset Alzheimer’s disease (LOAD) and is thought to interact adversely with other risk factors on the brain. However, evidence regarding the impact of APOE-ε4 on grey matter structure in as