Zobrazeno 1 - 10
of 1 992
pro vyhledávání: ''
Autor:
Jaimie Elowsky, Soonjo Hwang, Amanda Schwartz, Avantika Mathur, Karina S. Blair, Johannah Bashford-Largo, R. James R. Blair, Ru Zhang, Matthew Dobbertin, Sahil Bajaj, Ellen Leibenluft
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry
Translational Psychiatry
Previous studies examining structural brain correlates of irritability have taken a region-specific approach and have been relatively inconsistent. In a sample of adolescents with and without clinically impairing irritability, the current study exami
Autor:
Aafke Engwerda, Maarten P. van den Berg, Wilhelmina S. Kerstjens-Frederikse, Yvonne J. Vos, Bert B.A. de Vries, Tuula Rinne, Marc T R Roofthooft, Paulien A Terhal, Patrick Deelen, Conny M. A. van Ravenswaaij-Arts, Barbara Frentz, Katharina Löhner, Trijnie Dijkhuizen, Erika Leenders
Publikováno v:
European Journal of Human Genetics, 29, 1669-1676. Nature Publishing Group
Eur J Hum Genet
Eur J Hum Genet
Deletions that include the gene TAB2 and TAB2 loss-of-function variants have previously been associated with congenital heart defects and cardiomyopathy. However, other features, including short stature, facial dysmorphisms, connective tissue abnorma
Autor:
Fred H. Gage, Caroline Becronis, Amy T. Le, Krishna C. Vadodaria, Michelle K. Skime, Timothy J. Nelson, Kelly J. Heard, Callie Fredlender, Richard M. Weinshilboum, Yuan Ji, Maxim N. Shokhirev, Daniel K. Hall-Flavin, Nadia Zahid
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortis
Autor:
Yuan-Ting Kuo, Kai-Ti Lin, Yi-Hsiang Wang, Wen-Hung Kuo, Chia-Yi Shen, Lu-Hai Wang, Wen-Ching Wang, Yu-Ling Hsu, Sheng-Chieh Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast ca
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Autor:
Shenshen Wu, Xiaobo Li, Xinwei Zhang, Haitao Zhu, Qingtao Meng, Michael Aschner, Michela Relucenti, Bin Li, Jun Yun, Rui Chen, Jie Xu, Hongbao Yang, Giuseppe Familiari, Hao Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients f
Autor:
Yifang Liu, Jiaojiao Yang, Li Luo, Wei Wu, Kaijing Zhong, Jiyao Li, Mingyue Han, Lizhong Sun, Shijie Shi, Libang He
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-14 (2021)
International Journal of Oral Science
International Journal of Oral Science
Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflamm
Autor:
Gordon D. Waiter, Claire Green, Mathew A. Harris, J. Douglas Steele, Anca-Larisa Sandu, Joanna M. Wardlaw, David J. Porteous, Heather C. Whalley, Liana Romaniuk, Emma L. Hawkins, Rebecca M. Reynolds, Xueyi Shen, Miruna C. Barbu, Aleks Stolicyn, Jonathan R. Seckl, Andrew M. McIntosh, Stephen M. Lawrie, Jonathan Cavanagh, Archie Campbell
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Green, C, Stolicyn, A, Harris, M A, Shen, X, Romaniuk, L, Barbu, M C, Hawkins, E L, Wardlaw, J M, Steele, J D, Waiter, G D, Sandu, A, Campbell, A, Porteous, D J, Seckl, J R, Lawrie, S M, Reynolds, R M, Cavanagh, J, Mcintosh, A M & Whalley, H C 2021, ' Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland ', Translational Psychiatry, vol. 11, no. 1 . https://doi.org/10.1038/s41398-021-01644-9
Translational Psychiatry
Green, C, Stolicyn, A, Harris, M A, Shen, X, Romaniuk, L, Barbu, M C, Hawkins, E L, Wardlaw, J M, Steele, J D, Waiter, G D, Sandu, A, Campbell, A, Porteous, D J, Seckl, J R, Lawrie, S M, Reynolds, R M, Cavanagh, J, Mcintosh, A M & Whalley, H C 2021, ' Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland ', Translational Psychiatry, vol. 11, no. 1 . https://doi.org/10.1038/s41398-021-01644-9
Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of results; potentially due to the predominant use of acute measures of an inherently varia
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Translational Psychiatry
Translational Psychiatry
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a subset of people with schizophrenia, with significant increases in inflammatory markers including several cytokines. Yet the cause(s) of cortical inflamma
Autor:
Sandra Orozco-Suárez, Norma Oviedo, Minerva Crespo Ramírez, Leticia Manuel-Apolinar, Miguel Pérez de la Mora, Vilma Carolina Bekker-Méndez, Vladimir Paredes-Cervantes, Emiliano Tesoro-Cruz, Sandra Angélica Rojas-Osornio, M. Magdalena Aguirre-García
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Translational Psychiatry
Translational Psychiatry
Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. In the la
Autor:
Xiuying Li, Tiao Li, Seyed Mehdi Nouraie, Janet S. Lee, Kong Chen, Georgios D Kitsios, Rama K. Mallampalli, Bryan J. McVerry, Yingze Zhang, Yandong Lai, Chunbin Zou, Toru Nyunoya
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Lung epithelial cell death is a prominent feature of acute lung injury and acute respiratory distress syndrome (ALI/ARDS), which results from severe pulmonary infection leading to respiratory failure. Multiple mechanisms are believed to contribute to