Zobrazeno 1 - 10
of 1 271
pro vyhledávání: ''
Autor:
Fred H. Gage, Caroline Becronis, Amy T. Le, Krishna C. Vadodaria, Michelle K. Skime, Timothy J. Nelson, Kelly J. Heard, Callie Fredlender, Richard M. Weinshilboum, Yuan Ji, Maxim N. Shokhirev, Daniel K. Hall-Flavin, Nadia Zahid
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortis
Autor:
Sandra Orozco-Suárez, Norma Oviedo, Minerva Crespo Ramírez, Leticia Manuel-Apolinar, Miguel Pérez de la Mora, Vilma Carolina Bekker-Méndez, Vladimir Paredes-Cervantes, Emiliano Tesoro-Cruz, Sandra Angélica Rojas-Osornio, M. Magdalena Aguirre-García
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Translational Psychiatry
Translational Psychiatry
Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. In the la
Autor:
Federica Urciuolo, Federica Campanelli, Gioia Marino, Antonio de Iure, Maurizio Bossola, Veronica Ghiglieri, Giuseppina Natale, Valeria Calabrese, Paolo Calabresi, Barbara Picconi
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-6 (2021)
Cell Death Discovery
Cell Death Discovery
Patients affected by chronic kidney disease (CKD) have an increased risk of developing cognitive impairment. The cause of mental health disorders in CKD and in chronic hemodialysis patients is multifactorial, due to the interaction of classical cardi
Autor:
Gustavo Turecki, Claudio N. Soares, Andrew D. Davis, Stephen R. Arnott, Jacqueline K. Harris, Nikita Nogovitsyn, Sidney H. Kennedy, Laura M. Fiori, Glenda MacQueen, Benicio N. Frey, Roumen Milev, Jane A. Foster, Stefanie Hassel, Antoine Yrondi, Susan Rotzinger, Stephen C. Strother, Daniel J. Müller, Jean-François Théroux, Zahia Aouabed, Raymond W. Lam, Mojdeh Zamyadi
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
The pathophysiology of major depressive disorder (MDD) encompasses an array of changes at molecular and neurobiological levels. As chronic stress promotes neurotoxicity there are alterations in the expression of genes and gene-regulatory molecules. T
Autor:
Kelly K Noah, Geeta Sarphare, Elaine Tierney, Forbes D. Porter, Audrey Thurm, Irena Bukelis, Christopher A. Wassif, Joan E. Bailey-Wilson, Lisa E. Kratz, Leah Jager, Alan T. Remaley, Eun Sol Jung, Boudewien Brand
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with
Autor:
Xueyan Wang, Valentin David, Samantha Neuburg, Claire Gerber, Guillaume Courbon, Emily Lynch, Connor Francis, Myles Wolf, Jodie L. Babitt, Tamara Isakova, Aline Martin
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Bone Research
Bone Research
Bone-produced fibroblast growth factor 23 (FGF23) increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2;
Autor:
Froukje Vanweert, Dennis O. Mook-Kanamori, Esther Phielix, Renée de Mutsert, Patrick Schrauwen, Frits R. Rosendaal, Hildo J. Lamb, Sebastiaan C. Boone, Bram Brouwers, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling
Publikováno v:
International Journal of Obesity (2005)
International Journal of Obesity, 45(7), 1510-1520. Nature Publishing Group
International Journal of Obesity, 45(7), 1510-1520. SPRINGERNATURE
International Journal of Obesity, 45(7), 1510-1520. Nature Publishing Group
International Journal of Obesity, 45(7), 1510-1520. SPRINGERNATURE
Aims To evaluate whether the association between plasma branched-chain amino acids (BCAA) and intrahepatic lipid (IHL) was affected by physical activity level. Furthermore, to investigate if a conventional exercise training program, a subcategory of
Autor:
Marina Quinlan, Maria Rogdaki, Alaine Berry, Anthony C. Vernon, Thomas Whitehurst, Sridhar Natesan, Ellis Chika Onwordi, Ben Statton, Roger N. Gunn, Tiago Reis Marques, Oliver D. Howes, Ayla Mansur, Declan P. O'Regan, Eugenii A. Rabiner
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic function in vivo. Additionally, it has been proposed that N-acetyl aspartate
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-9 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background The beneficial effects of ω−3 polyunsaturated fatty acids (PUFA) vary between different sources. However, there is a paucity of comparative studies regarding the effects and mechanisms of marine and plant ω−3 PUFA on obesity. Objecti
Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar