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Autor:
Yan Dai, Jiaming Zhu, Zhihui Lu, Yi Fang, Hong Liu, Jing Chen, Jiachang Hu, Yiran Liang, Jianzhou Zou, Xiaoqiang Ding, Yichun Ning, Nana Song, Jie Teng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)
Podocytes are known to play a determining role in the progression of proteinuric kidney disease. N6-methyladenosine (m6A), as the most abundant chemical modification in eukaryotic mRNA, has been reported to participate in various pathological process
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Conventional chemotherapy is still of great utility in oncology and rationally constructing combinations with it remains a top priority. Drug-induced mitochondrial apoptotic priming, measured by dynamic BH3 profiling (DBP), has been shown in multiple
Autor:
Shoubao Ma, Huanle Gong, Haiyan Liu, Yuhui Huang, Bingyu Yang, Xianfeng Zhang, Chen Dong, Depei Wu, Xiaojin Wu, Chang Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-4 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-9 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background The beneficial effects of ω−3 polyunsaturated fatty acids (PUFA) vary between different sources. However, there is a paucity of comparative studies regarding the effects and mechanisms of marine and plant ω−3 PUFA on obesity. Objecti
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 6, Pp 1-9 (2021)
Blood Cancer Journal
Blood Cancer Journal
In 1957, Hillestad et al. defined acute promyelocytic leukemia (APL) for the first time in the literature as a distinct type of acute myeloid leukemia (AML) with a “rapid downhill course” characterized with a severe bleeding tendency. APL, accoun
Autor:
Walter Wang, Johan Schultz, David P. Carbone, Mohammad Hojjat-Farsangi, Håkan Mellstedt, Joseph M. Amann, Alyssa Shulman, Konstantin Shilo, Carlo M. Croce
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
Small cell lung cancer (SCLC) remains a deadly form of cancer, with a 5-year survival rate of less than 10 percent, necessitating novel therapies. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein that is emerging as a th
Autor:
Junni Wang, Jianghua Chen, Ying Wang, Huanhuan Zhu, Xi Yao, Yuan Yuan, Xianghui Fu, Weiqiang Lin, Yunjing Zhang, Yin-Wu Bao, Mengqiu Bai, Jianhua Mao, Xishao Xie, Yi Yang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Demethylase Tet2 plays a vital role in the immune response. Acute kidney injury (AKI) initiation and maintenance phases are marked by inflammatory responses and leukocyte recruitment in endothelial and tubular cell injury processes. However, the role
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Ovarian cancer is the most lethal gynecological cancer in the US. Standard treatment consists of surgery followed by chemotherapies relying on apoptotic tumor cell death. Most women with advanced stage disease will relapse, suggesting that this disea
Autor:
Patricia M. L. A. van den Bemt, Ingrid A. Boere, Roelof W F van Leeuwen, Esther Oomen-de Hoop, Juul M. Cox, Tessa M. Bosch, Ruben Malmberg, Leni van Doorn, Agnes Jager, Ron H.J. Mathijssen
Publikováno v:
British Journal of Cancer, 124(10), 1647-1652. Nature Publishing Group
Background: Ranitidine, a histamine 2 blocker, is the standard of care to prevent hypersensitivity reactions (HSRs) caused by paclitaxel infusion. However, the added value of ranitidine in this premedication regimen is controversial. Therefore, we co
Autor:
Wei Lu, Kui Guo, Jie Jiang, Chunping Qiu, Tianyi Zhao, Hong Yan, Zhiming Liu, Lina Wei, Xiaohong Ma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-21 (2021)
Cell Death & Disease
Cell Death & Disease
Progesterone resistance can significantly restrict the efficacy of conservative treatment for patients with endometrial cancer who wish to preserve their fertility or those who suffer from advanced and recurrent cancer. SREBP1 is known to be involved