Zobrazeno 1 - 10
of 322
pro vyhledávání: ''
Autor:
Hillary Protas, Dimitri Avramopoulos, Kewei Chen, Eric M. Reiman, Gwenn S. Smith, Jin Hui Joo, Alena Savonenko, Yi Su, Neda F Gould, Ayon Nandi, Hiroto Kuwabara, Clifford I. Workman, Michael A. Kraut
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodegenerative mechanisms that are common to de
Autor:
Shoubao Ma, Huanle Gong, Haiyan Liu, Yuhui Huang, Bingyu Yang, Xianfeng Zhang, Chen Dong, Depei Wu, Xiaojin Wu, Chang Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-4 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-9 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background The beneficial effects of ω−3 polyunsaturated fatty acids (PUFA) vary between different sources. However, there is a paucity of comparative studies regarding the effects and mechanisms of marine and plant ω−3 PUFA on obesity. Objecti
Autor:
Christine Hartmann, Lena I. Wolff, Jessica Bertrand, Christine Fabritius, Stefan Teufel, Petra Köckemann, Thomas Pap
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Agonists and antagonists of the canonical Wnt signaling pathway are modulators of pathological aspects of rheumatoid arthritis (RA). Their activity is primarily modifying bone loss and bone formation, as shown in animal models of RA. More recently, m
Autor:
Takashi Nakamura, Mai Nampei, Takayo Murase, Hiroki Mizukami, Noriaki Katoh, Seigo Akari, Etsuko Satoh
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-5 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed stan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Repulsive guidance molecule-a (RGMa), a glycosylphosphatidylinositol-anchored membrane protein, has diverse functions in axon guidance, cell patterning, and cell survival. Inhibition of RGMa attenuates pathological dysfunction in animal models of cen
Autor:
Zhixia Chen, Xibing Ding, Quan Li, Mengzhu Li, Renlingzi Zhang, Lingling Zhang, Xiaoyin Niu, Zhuang Yu, Bruce R. Pitt, Yao Tong, Timothy R. Billiar, Xiaohu Yang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Imbalance of macrophage polarization plays an indispensable role in acute lung injury (ALI), which is considered as a promising target. Matrix metalloproteinase-9 (MMP-9) is expressed in the macrophage, and has a pivotal role in secreting inflammator
Autor:
Chi-Ping Huang, Junfeng Yu, Xiangyun You, Chawnshang Chang, Yin Sun, Meng Zhang, Bosen You, Zhendong Xiang, Denglong Wu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Most patients with advanced prostate cancer (PCa) initially respond well to androgen deprivation therapy (ADT) with antiandrogens, but most of them eventually become resistant to ADT. Here, we found that the antiandrogen Enzalutamide-resistant (EnzR)
Autor:
Alka Bhatia, Amanjit Bal, Neeraj Khatri, Shivani Jaiswal, Nayudu Nallabelli, Vivek Singh Malik, Deep Maheshwari, Rajesh Kumar, Neenu Jacob, Naresh Sachdeva, Savita Verma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Type-1 diabetes (T1D) is an autoimmune disease caused by progressive loss of insulin-producing beta cells in the pancreas. Butyrate is a commensal microbial-derived metabolite, implicated in intestinal homeostasis and immune regulation. Here, we inve
Autor:
Tianwu Yang, Junfei Zhou, Xue Liang, Tianzhen Han, Chen Zhao, Yu Liu, Jiaxin Li, Xuemei Ji, Nannan Kang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-13 (2020)
Cell Death & Disease
Cell Death & Disease
Bevacizumab in neoadjuvant therapy provides a new hope of improved survival for patients with triple-negative breast cancer (TNBC) by targeting vascular endothelial growth factor in combination with chemotherapy, but curative effect is limited by bev