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pro vyhledávání: ''
Autor:
Zhonghua Zhao, Huijuan Wu, Jinfang Bao, Jun Liu, Yili Fang, Nan Zhu, Chenyang Qi, Zhihuang Zheng, Chuanlei Li, Kexin Xu, Qing Yu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Nod-like receptor protein 3 (NLRP3), as an inflammatory regulator, has been implicated in acute kidney injury (AKI). Failed recovery after AKI can lead to chronic kidney disease (CKD). However, the role of NLRP3 in the AKI-CKD transition is still unk
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-7 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
This study (ORIENT-4) aimed to assess the efficacy and safety of sintilimab, a humanized anti-PD-1 antibody, in patients with relapsed/refractory extranodal NK/T cell lymphoma (r/r ENKTL). ORIENT-4 is a multicenter, single-arm, phase 2 clinical trial
Autor:
Jacalyn Rosenblatt, Diane Warren, Kelly Masone, Dena Grayson, Sascha A. Tuchman, Kathleen Colson, Paul G. Richardson, Jacob P. Laubach, Robert A. Redd, Constantine S. Mitsiades
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-8 (2021)
Blood Cancer Journal
Blood Cancer Journal
Additional therapeutic options are needed for relapsed and refractory multiple myeloma (RRMM). We present data from a phase 1b, open-label, dose-escalation study (NCT01965353) of 20 patients with RRMM (median age: 63 years [range: 50–77]) and a med
Autor:
Luiza Ferreira Sperb, Juliano Soares Rabello Moreira, Luciana Verçoza Viana, Maria Elisa P. Muller, Thais Steemburgo, Tatiana Pedroso de Paula
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Scientific Reports
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Observational and experimental data reinforce the concept that vitamin D is associated with the pathogenesis of arterial hypertension. We investigated the effect of a single dose of 100,000 IU of cholecalciferol, in office blood pressure (BP), and 24
Autor:
Soon Jun Hong, Cheol Woong Yu, Jae Hyoung Park, Jae Young Cho, Duck Hyun Jang, Jong-Ho Kim, Hyung Joon Joo, Sang A. Cho, Do Sun Lim, Hyungdon Kook
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), neutrophil gelatinase-associated lipocalin (NGAL), and matrix metalloproteinase-9 (MMP-9) are inflammatory biomarkers involved in plaque destabilization resulting in acute coro
Autor:
Alejandro Balsa, Ana M. Ortiz, Laura Nuño, Cristina Regueiro, Ana Martínez-Feito, Diana Peiteado, Ana Triguero-Martinez, Isidoro González-Álvaro, Alejandro Villalba, Holger Bang, L Rodriguez-Martinez, Antonio Gonzalez
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Scientific Reports
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Scientific Reports
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
The presence of rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) autoantibodies contributes to the current rheumatoid arthritis (RA) classification criteria. These criteria involve stratification on antibody levels, which limits
Autor:
Yoji Ishizu, Kenta Yamamoto, Takashi Kumada, Norihiro Imai, Takanori Ito, Mitsuhiro Fujishiro, Masatoshi Ishigami, Daisaku Nishimura, Satoshi Yasuda, Toshifumi Tada, Hikaru Morooka, Takashi Honda, Hidenori Toyoda
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
The albumin–bilirubin (ALBI) score is calculated using only serum albumin and bilirubin levels, and was developed as a simple method to assess hepatic function. In this study, a total of 409 patients with primary biliary cholangitis (PBC) were enro
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
The current evidence regarding the association between vitamin D deficiency and cardiovascular diseases/metabolic disorders is contradictory and inconclusive. In this large-scale observational study, we investigated the relationship between the serum
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The proton pump inhibitor omeprazole is administered to dogs with gastroduodenal ulceration or oesophagitis, whereas the neurokinin-1 receptor antagonist maropitant citrate is licensed as an antiemetic drug. In people, omeprazole is overprescribed in
Autor:
Wenjing Qiao, Yiran Chong, Hailong Zhu, Jiayi Zhang, Shitao Zhao, Shutian Zhang, Yi Zhao, Wei Tao, Gang Wu, Ann M Vuong, De-Miao Zhu, Tianyi Wang, Baihui Tao, Jin-Cheng Li, Mengmeng Niu, Shuman Yang, Shuang Ma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
Scientific Reports
Scientific Reports
In vivo and vitro evidence indicates that ornithine and its related metabolic products play a role in tumor development. Whether ornithine is associated with breast cancer in humans is still unclear. We examined the association between circulating or