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Autor:
Bethania Fernandes, Massimo Roncalli, Corrado Tinterri, Alberto Testori, Giovanna Masci, Wolfgang Gatzemeier, Elisa Agostinetto, Agnese Losurdo, Rita De Sanctis, Valentina Errico, Armando Santoro, Rosalba Torrisi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Triple negative breast cancer (TNBC), usually presenting with a very aggressive phenotype, is a heterogeneous entity. We aim to discuss new biomarkers, suitable for prognostic and predictive purposes. We retrospectively collected clinical variables a
Autor:
Michael F. Press, Ali Madani, Nitish Shirish Keskar, David B. Agus, Daniel Ruderman, Nikhil Naik, Richard Socher, Andre Esteva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular marker used for prognosis and treatment decisions. During clinical management, ERS is determined by pathologists from immunohistochemistry (IHC) staining of biopsied
Autor:
Maïwenn Kersaudy-Kerhoas, Olga Oikonomidou, Nick R. Leslie, Ieva Keraite, Nicholas C. Turner, Isaac Garcia-Murillas, Clare Bartos, Virginia Alvarez-Garcia, Matthew Beaney
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Sci Rep . 2020 Oct 13;10(1):17082
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Keraite, I, Alvarez Garcia, V, Garcia-Murillas, I, Beaney, M, C Turner, N, Bartos, C, Oikonomidou, O, Kersaudy-Kerhoas, M & R. Leslie, N 2020, ' PIK3CA mutation enrichment and quantitation from blood and tissue ', Scientific Reports . https://doi.org/10.1038/s41598-020-74086-w
Scientific Reports
Sci Rep . 2020 Oct 13;10(1):17082
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Keraite, I, Alvarez Garcia, V, Garcia-Murillas, I, Beaney, M, C Turner, N, Bartos, C, Oikonomidou, O, Kersaudy-Kerhoas, M & R. Leslie, N 2020, ' PIK3CA mutation enrichment and quantitation from blood and tissue ', Scientific Reports . https://doi.org/10.1038/s41598-020-74086-w
PIK3CA is one of the two most frequently mutated genes in breast cancers, occurring in 30–40% of cases. Four frequent ‘hotspot’ PIK3CA mutations (E542K, E545K, H1047R and H1047L) account for 80–90% of all PIK3CA mutations in human malignancie
Autor:
Chi Jung Huang, Yuan Soon Ho, Hsin Tien Tsai, Shih Hsin Tu, Ching Shui Huang, Ling Ming Tseng, Chih Yi Liu, Chao Chiang Tu, Chi Cheng Huang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Microcalcification is one of the most common radiological and pathological features of breast ductal carcinoma in situ (DCIS), and to a lesser extent, invasive ductal carcinoma. We evaluated messenger RNA (mRNA) transcriptional profiles associated wi
Autor:
Kathy B. Baumgartner, Stephanie D. Boone, Yunfeng Cao, Avonne E. Connor, Kala Visvanathan, Richard N. Baumgartner
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-8 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Physical activity is recommended for most cancer patients as a nonpharmacological therapy to improve prognosis. Few studies have investigated the association between physical activity and breast cancer prognosis by ethnicity, biological, and modifiab
Autor:
Belal Azab, Munir Abu-Helalah, Abdalla Awidi, Hanan Jafar, Hussam Alshraideh, Dema Ali, Nizar Drou, Rasmi Mubaidin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Familial breast cancer is estimated to account for 15–20% of all cases of breast cancer. Surveillance for familial breast cancer is well-established world-wide. However, this service does not exist in Jordan, due to the scarcity of information with
Autor:
Gyungyub Gong, Byung Hee Jeon, Kyoung-Yeon Kim, Sei Hyun Ahn, YongNam Kim, Hee Jin Lee, Cham Han Lee, Il Yong Chung, Sung-chan Gwark, Mi Young Choi, Myoung Shin Kim, Ji Yeon Park, Jong Won Lee, Jisun Kim, Sae Byul Lee, Young Hun Kim, Kyung Hae Jung, Jin-Hee Ahn, Nak-Jung Kwon, Byung Ho Son, Suhwan Chang, Jonghan Yu, Sung Bae Kim, Hee Jeong Kim, Sung Woo Hong, Beom Seok Ko
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
We evaluated the prognostic implications of the circulating tumor cell (CTC) count in non-metastatic, HER2-negative breast cancer patients who failed to achieve pathologic complete response (pCR) after neoadjuvant chemotherapy (NCT). A total of 173,
Autor:
Lixi Li, Jingtong Zhai, Xiuwen Guan, Haili Qian, Hui Li, Quchang Ouyang, Jin Li, Binliang Liu, Fei Ma, Binghe Xu, Chunxiao Li, Yanfang Guan, Guohua Rong, Ling Yang, Zongbi Yi, Wenna Wang, Xin Yi, Chang Lianpeng, Xuefeng Xia, Lifeng Li
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-8 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. However, little is known about
Autor:
Haeng-Jin Lee, Ho Yong Park, Eun Kyu Kim, S. J. Nam, Kyu-Pyo Kim, HG Moon, Sinwon Lee, Byung-Ho Son, Yun-Shik Choi, YW Ju, Wonshik Han, Sung Ho Ahn, Hwan Ki Kim, Wookyung Park, Jaewang Lee, D-Y Noh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
We investigated the relationship between the prognostic importance of anatomic tumour burden and subtypes of breast cancer using data from the Korean Breast Cancer Registry Database. In HR+/HER2+ and HR−/HER2−tumours, an increase in T stage profo
Autor:
Céline Chapelle, Jane-Chloé Trone, Edouard Ollier, Nicolas Magné, Michel Cucherat, Paul Jacques Zuffrey, Patrick Mismetti, Silvy Laporte
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
The aim of this study was to propose a methodology for the assessment of non-inferiority with meta-analysis. Assessment of hypofractionated RT in prostate and breast cancers is used as an illustrative example. Non-inferiority assessment of an experim