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Autor:
Jee Hye Choi, Sangmyung Rhee, Sung Haeng Lee, Simon Lovestone, Lee Sael, Ah Ra Do, Jungsoo Gim, Suparna Ghosh, Sanghun Lee, Kyu Yeong Choi, SangYun Kim, Seula Keum, Juhong Park, Lindsay A. Farrer, Jang Jae Lee, Andrew J. Saykin, Gyun Jee Song, Byeong C. Kim, Kwangsik Nho, Jun Young Park, Eunae Kim, Kun Ho Lee, Immanuel Dhanasingh, Seung Hwan Moon, Hoowon Kim, Kyungtaek Park, Donghe Li, Jinyeon Jo, Tamil Iniyan Gunasekaran, Dong Soo Lee, Sungho Won, Sarang Kang, Gyungah Jun
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Established genetic risk factors for Alzheimer’s disease (AD) account for only a portion of AD heritability. The aim of this study was to identify novel associations between genetic variants and AD-specific brain atrophy. We conducted genome-wide a
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Autor:
Sara Hultberg, Kurt Wahlstedt, Margareta Reis, Jörgen Rosén, Kristoffer N.T. Månsson, Olof R. Hjorth, Malin Gingnell, Vanda Faria, Andreas Frick, Johanna M. Hoppe, Mark Lubberink, Mats Fredrikson, Iman Alaie, Tomas Furmark, Gunnar Antoni, My Jonasson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with serotonin transporte
Autor:
Kelly K Noah, Geeta Sarphare, Elaine Tierney, Forbes D. Porter, Audrey Thurm, Irena Bukelis, Christopher A. Wassif, Joan E. Bailey-Wilson, Lisa E. Kratz, Leah Jager, Alan T. Remaley, Eun Sol Jung, Boudewien Brand
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with
Autor:
Xiuying Li, Tiao Li, Seyed Mehdi Nouraie, Janet S. Lee, Kong Chen, Georgios D Kitsios, Rama K. Mallampalli, Bryan J. McVerry, Yingze Zhang, Yandong Lai, Chunbin Zou, Toru Nyunoya
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Lung epithelial cell death is a prominent feature of acute lung injury and acute respiratory distress syndrome (ALI/ARDS), which results from severe pulmonary infection leading to respiratory failure. Multiple mechanisms are believed to contribute to
Autor:
Naval Daver, Jing Ning, Guillermo Garcia-Manero, Tapan M. Kadia, Hagop M. Kantarjian, Nicholas J. Short, Wei Qiao, Daewoo Pak, Jabra Zarka, Farhad Ravandi, Marina Konopleva, Fadi Haddad, Zhenya Tang, Keyur P. Patel, Ghayas C. Issa, Elias Jabbour, Gautam Borthakur, Courtney D. DiNardo, Branko Cuglievan, Koji Sasaki, Michael Andreeff
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Acute myeloid leukemia (AML) with rearrangement of the lysine methyltransferase 2a gene (KMT2Ar) has adverse outcomes. However, reports on the prognostic impact of various translocations causing KMT2Ar are conflicting. Less is known about associated
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
The lncRNA ZFAS1 plays a carcinogenic regulatory role in many human tumours, but it is rarely reported in pancreatic cancer. We identify the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in
Autor:
Hillary Protas, Dimitri Avramopoulos, Kewei Chen, Eric M. Reiman, Gwenn S. Smith, Jin Hui Joo, Alena Savonenko, Yi Su, Neda F Gould, Ayon Nandi, Hiroto Kuwabara, Clifford I. Workman, Michael A. Kraut
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodegenerative mechanisms that are common to de
Autor:
Ying Zhang, Junbo Liang, Zhewen Wei, Mei Liu, Qing Zhu, Chunfeng Qu, Mo Li, Yarui Ma, Huan He, Jianqiang Cai, Yi Xin Zeng, Xiaobing Wang, Yuchen Jiao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma (HCC) in individuals infected with the hepatitis virus. However, the molecular pathways leading to its bioactivation and subsequent toxicity in he
Autor:
Zhang Zhen, Zhang Yilu, Li Weiwei, Xu Zhenchao, Xiao Xiao, Ye Hongru, Rong Dingchao, Wu Yunqi, Xiyang Wang, Xie Liqiong
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Cell Death Discovery
Cell Death Discovery
Spinal cord injury (SCI) is a salient traumatic disease that often leads to permanent disability, and motor and sensory impairments. Human umbilical cord mesenchymal stem cells (HucMSCs) have a wide application prospect in the treatment of SCI. This