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Autor:
Jian-Hong Shi, Chen Ling, Ting-Ting Wang, Li-Nuo Zhang, Wen-Wen Liu, Yan Qin, Ying-Hui Tan, Nai-Peng Cui, Zhi-Yu Ni
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
Cell Death & Disease
Cell Death & Disease
TRK-fused gene (TFG) is known to be involved in protein secretion and plays essential roles in an antiviral innate immune response. However, its function in LPS-induced inflammation and pyroptotic cell death is still unknown. Here, we reported that T
Autor:
Grimm, Juliane, Simnica, Donjete, Jäkel, Nadja, Paschold, Lisa, Willscher, Edith, Schulze, Susann, Dierks, Christine, Al-Ali, Haifa Kathrin, Binder, Mascha
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-10 (2022)
Blood Cancer Journal
Blood Cancer Journal
Hypomethylating agents (HMA) like azacitidine are licensed for the treatment of acute myeloid leukemia (AML) patients ineligible for allogeneic hematopoietic stem cell transplantation. Biomarker-driven identification of HMA-responsive patients may fa
Autor:
Ji, Peirui, Yang, Shuming, Wang, Yu, Li, Kaili, Wang, Yiming, Suo, Hao, Woldu, Yonas Tesfaye, Wang, Xiaomin, Wang, Fei, Zhang, Liangliang, Jiang, Zhuangde
Publikováno v:
Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-9 (2022)
Microsystems & Nanoengineering
Microsystems & Nanoengineering
Graphene/silicon Schottky junctions have been proven efficient for photodetection, but the existing high dark current seriously restricts applications such as weak signal detection. In this paper, a thin layer of gadolinium iron garnet (Gd3Fe5O12, Gd
Autor:
Xun Zhang, Xueling Suo, Xun Yang, Han Lai, Nanfang Pan, Min He, Qingyuan Li, Weihong Kuang, Song Wang, Qiyong Gong
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Translational Psychiatry
Translational Psychiatry
Although functional and structural abnormalities in brain regions involved in the neurobiology of fear and anxiety have been observed in patients with social anxiety disorder (SAD), the findings have been heterogeneous due to small sample sizes, demo
Autor:
Léa, Karpf, Coline, Trichot, Lilith, Faucheux, Iris, Legbre, Maximilien, Grandclaudon, Charlotte, Lahoute, Hamid, Mattoo, Benoit, Pasquier, Vassili, Soumelis
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-16 (2022)
Cell Discovery
Cell Discovery
Cells receive, and adjust to, various stimuli, which function as part of complex microenvironments forming their “context”. The possibility that a given context impacts the response to a given stimulus defines “context-dependency” and it expl
Autor:
Carabias, Pablo, Espelt, María V., Bacigalupo, María L., Rojas, Paola, Sarrias, Luciana, Rubin, Ayelén, Saffioti, Nicolás A., Elola, María T., Rossi, Juan P., Wolfenstein-Todel, Carlota, Rabinovich, Gabriel A., Troncoso, María F.
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-14 (2022)
Cell Death & Disease
Cell Death & Disease
Galectin-1 (GAL1), a β-galactoside-binding protein abundantly expressed in the tumor microenvironment, has emerged as a key mechanism of chemoresistance developed by different tumors. Although increased expression of GAL1 is a hallmark of hepatocell
Autor:
Sangeetha Venugopal, Koichi Takahashi, Naval Daver, Abhishek Maiti, Gautam Borthakur, Sanam Loghavi, Nicholas. J. Short, Maro Ohanian, Lucia Masarova, Ghayas Issa, Xuemei Wang, Bueso-Ramos Carlos, Musa Yilmaz, Tapan Kadia, Michael Andreeff, Farhad Ravandi, Marina Konopleva, Hagop M. Kantarjian, Courtney D. DiNardo
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-7 (2022)
Blood Cancer Journal
Blood Cancer Journal
Preclinically, enasidenib and azacitidine (ENA + AZA) synergistically enhance cell differentiation, and venetoclax (VEN), a small molecule Bcl2 inhibitor (i) is particularly effective in IDH2 mutated acute myeloid leukemia (IDH2mutAML). This open lab
Autor:
Yu Deng, Zhuo-Fei Fan, Bin-Bin Zhao, Xing-Guang Wang, Shiyuan Zhao, Jiagui Wu, Frédéric Grillot, Cheng Wang
Publikováno v:
Light: Science & Applications, Vol 11, Iss 1, Pp 1-10 (2022)
Light, Science & Applications
Light, Science & Applications
Chaos in nonlinear dynamical systems is featured with irregular appearance and with high sensitivity to initial conditions. Near-infrared light chaos based on semiconductor lasers has been extensively studied and has enabled various applications. Her
Autor:
Zhiyuan Zhang, Guodong He, Yang Lv, Yu Liu, Zhengchuan Niu, Qingyang Feng, Ronggui Hu, Jianmin Xu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Cell Death & Disease
Cell Death & Disease
E3 ligase is widely reported to exert fundamental functions in cancers. Through rigorous bioinformatic analysis concentrating E3 ligases based on data from Genotype-Tissue Expression (GTEx) and data from The Cancer Genome Atlas (TCGA), HERC3 was indi
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-14 (2022)
Bone Research
Bone Research
The periosteum, a highly vascularized thin tissue, has excellent osteogenic and bone regenerative abilities. The generation of periosteum-mimicking tissue has become a novel strategy for bone defect repair and regeneration, especially in critical-siz