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Autor:
Xiao Feng Zhu, Zhuo-Yan Zhong, Kaiming Zhang, Xiao-Jun Qian, Yu-Hong Chen, Yan Yu, Shun Li, Xue-Lian Xu, Dong Yang, Li-Huan Zhou, Hai-Liang Zhang, Gong-Kan Feng, Rong Deng, Jun-Dong Li, Xuan Li, Yun-Tian Li, Yun Huang, Xiao-Dan Peng, Zhi-Ling Li, Xiang Huang, Jia Mai
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial networ
Autor:
Herbert Chen, Ronadip R. Banerjee, Deepti Dhall, Priyanka Gupta, Fabrice Viol, Rachael Guenter, M. Shahid Mukhtar, Frank Gillardon, Eugene A. Woltering, James A. Bibb, Angela M. Carter, Chunfeng Tan, John Totenhagen, Tyler R. McCaw, Hayden H Bickerton, Nilesh Kumar, J. Bart Rose, Elizabeth M. Kurian, Wayne Howse, Rahul Telange, Joerg Schrader, Sushanth Reddy, Brendon Herring
Publikováno v:
Oncogenesis, Vol 10, Iss 12, Pp 1-13 (2021)
Oncogenesis
Oncogenesis
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous population of neoplasms that arise from hormone-secreting islet cells of the pancreas and have increased markedly in incidence over the past four decades. Non-functional PanNETs, which oc
Autor:
Jaimie Elowsky, Soonjo Hwang, Amanda Schwartz, Avantika Mathur, Karina S. Blair, Johannah Bashford-Largo, R. James R. Blair, Ru Zhang, Matthew Dobbertin, Sahil Bajaj, Ellen Leibenluft
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry
Translational Psychiatry
Previous studies examining structural brain correlates of irritability have taken a region-specific approach and have been relatively inconsistent. In a sample of adolescents with and without clinically impairing irritability, the current study exami
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
The role of Golgi/endosome-localized clathrin adapters in the maintenance of steady-state cell surface epidermal growth factor receptor (EGFR) is not well known. Here, we show that EGFR associates preferentially with both AP-1 and GGA2 in vitro. AP-1
Autor:
Giorgio Zauli, Barbara Toffoli, Federica Tonon, Veronica Tisato, Bruno Fabris, Paola Secchiero, Stella Bernardi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
TNF-related apoptosis-inducing ligand (TRAIL) is a protein that induces apoptosis in cancer cells but not in normal ones, where its effects remain to be fully understood. Previous studies have shown that in high-fat diet (HFD)-fed mice, TRAIL treatme
Autor:
Rui Zhang, Lu Liu, Lu Lu, Yan Geng, Wenwei Zhu, Zhifei Lin, Lun-Xiu Qin, Ming Lu, Minghao Fan, Hu-Liang Jia, Jinhong Chen, Ju-Bo Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis. However, little is known abo
Autor:
Min Zhou, Xiaoyu He, Yiyi Feng, Renbing Jia, Jiayan Fan, Yongyun Li, Xiaofang Xu, Chunyan Zong, Yanping Han, Jie Yang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing o
Autor:
Aafke Engwerda, Maarten P. van den Berg, Wilhelmina S. Kerstjens-Frederikse, Yvonne J. Vos, Bert B.A. de Vries, Tuula Rinne, Marc T R Roofthooft, Paulien A Terhal, Patrick Deelen, Conny M. A. van Ravenswaaij-Arts, Barbara Frentz, Katharina Löhner, Trijnie Dijkhuizen, Erika Leenders
Publikováno v:
European Journal of Human Genetics, 29, 1669-1676. Nature Publishing Group
Eur J Hum Genet
Eur J Hum Genet
Deletions that include the gene TAB2 and TAB2 loss-of-function variants have previously been associated with congenital heart defects and cardiomyopathy. However, other features, including short stature, facial dysmorphisms, connective tissue abnorma
Autor:
Mike Angstadt, Mary M. Heitzeg, Luke W. Hyde, Tristan Greathouse, Brian M. Hicks, Saige Rutherford, D. Angus Clark, Sarah J. Brislin, Aman Taxali, Daniel Kessler, Alexander Weigard, Chandra Sripada
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Translational Psychiatry
Translational Psychiatry
Convergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns as
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Tribbles homolog 1 (TRIB1) belongs to the Tribbles family of pseudokinases, which plays a key role in tumorigenesis and inflammation. Although genome-wide analysis shows that TRIB1 expression is highly correlated with blood lipid levels, the relation