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Autor:
Giorgio Zauli, Barbara Toffoli, Federica Tonon, Veronica Tisato, Bruno Fabris, Paola Secchiero, Stella Bernardi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
TNF-related apoptosis-inducing ligand (TRAIL) is a protein that induces apoptosis in cancer cells but not in normal ones, where its effects remain to be fully understood. Previous studies have shown that in high-fat diet (HFD)-fed mice, TRAIL treatme
Autor:
Rui Zhang, Lu Liu, Lu Lu, Yan Geng, Wenwei Zhu, Zhifei Lin, Lun-Xiu Qin, Ming Lu, Minghao Fan, Hu-Liang Jia, Jinhong Chen, Ju-Bo Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis. However, little is known abo
Autor:
Yuan-Ting Kuo, Kai-Ti Lin, Yi-Hsiang Wang, Wen-Hung Kuo, Chia-Yi Shen, Lu-Hai Wang, Wen-Ching Wang, Yu-Ling Hsu, Sheng-Chieh Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast ca
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Autor:
Shenshen Wu, Xiaobo Li, Xinwei Zhang, Haitao Zhu, Qingtao Meng, Michael Aschner, Michela Relucenti, Bin Li, Jun Yun, Rui Chen, Jie Xu, Hongbao Yang, Giuseppe Familiari, Hao Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients f
Autor:
Qiuji Wu, Yurong Tu, Ziyue Xiang, Yibo Ying, Sheng Sunren, Jiahui Ye, Xiaoyang Li, Chen Min, Weiyang Ying, Zhiyang Huang, Sipin Zhu, Haicheng Dou
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
The ischemia and hypoxia microenvironment after spinal cord injury (SCI) makes SCI repair a challenging problem. With various stimulus, chances for neural stem cells (NSCs) to differentiate into neurons, astrocytes, oligodendrocytes are great and is
Autor:
Rosario Caltabiano, Renato Bernardini, Chiara Burgaletto, Giuseppina Cantarella, Salvatore Saccone, Antonio Munafò, Federica Conti, Chiara Bianca Maria Platania, Giovanni Giurdanella, Concetta Federico, Claudio Bucolo, Giulia Di Benedetto
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Age-related disorders, such as Alzheimer’s disease (AD) and age-related macular degeneration (AMD) share common features such as amyloid-β (Aβ) protein accumulation. Retinal deposition of Aβ aggregates in AMD patients has suggested a potential l
Autor:
Tongguo Shi, Yuqi Chen, Yanjun Chen, Juntao Li, Jiayu Wang, Hongya Wu, Suhua Xia, Xueguang Zhang, Zhendong Yao, Linqing Sun, Weichang Chen, Jinghan Zhu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Negative immune checkpoint blockade immunotherapy has shown potential for multiple malignancies including colorectal cancer (CRC). B7-H5, a novel negative immune checkpoint regulator, is highly expressed in tumor tissues and promotes tumor immune esc
Autor:
Lei Tao, Cong He, Ying Zhou, Yaoxin Gao, Sijia Cheng, Jie Yao, Wenzheng Jiang, Yixin Duan, Mingyao Liu, Iqra Ajmal, Muhammad Asad Farooq, Li Zhang, Shijia Wu, Haizhen Lin, Dandan Guo
Publikováno v:
Oncogenesis, Vol 10, Iss 9, Pp 1-9 (2021)
Oncogenesis
Oncogenesis
Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in the treatment of hematological malignancies. However, lack of tumor-specific targets and the existe
Autor:
Shuwei Zheng, Weiqiang Li, Huijian Li, Xingqiang Lai, Tao Wang, Yuanchen Ma, Zhipeng Tan, Yi Wang, Jiancheng Wang, Peng Luo, Hong Chen, Kai Xia, Weijun Huang, Chao Wang, Lin Dong, Xiaoyan Liang, Andy Peng Xiang, Qiong Ke, Jianhui Chen, Frank Fuxiang Mao
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Cell Discovery
Cell Discovery
Premature ovarian insufficiency (POI) is defined as the loss of ovarian activity under the age of 40. Theca cells (TCs) play a vital role during folliculogenesis and TCs dysfunction participate in the pathogenesis of POI. Therefore, transplantation o
Autor:
Sonja de Groot, Evelien Jansen, C. A. J. Smit, Maria T. E. Hopman, Dick H. J. Thijssen, Thomas W. J. Janssen
Publikováno v:
Spinal Cord Series and Cases, 7, 1
Spinal cord series and cases, 7(1):54. SPRINGERNATURE
Jansen, E, de Groot, S, Smit, C A, Thijssen, D H J, TE Hopman, M & Janssen, T W J 2021, ' Vascular adaptations in nonstimulated areas during hybrid cycling or handcycling in people with a spinal cord injury : a pilot study of 10 cases ', Spinal cord series and cases, vol. 7, no. 1, 54, pp. 1-6 . https://doi.org/10.1038/s41394-021-00417-2
Spinal cord series and cases, 7(1):54, 1-6. Nature Publishing Group
Spinal Cord Series and Cases, 7
Spinal Cord Ser Cases
Spinal cord series and cases, 7(1):54. SPRINGERNATURE
Jansen, E, de Groot, S, Smit, C A, Thijssen, D H J, TE Hopman, M & Janssen, T W J 2021, ' Vascular adaptations in nonstimulated areas during hybrid cycling or handcycling in people with a spinal cord injury : a pilot study of 10 cases ', Spinal cord series and cases, vol. 7, no. 1, 54, pp. 1-6 . https://doi.org/10.1038/s41394-021-00417-2
Spinal cord series and cases, 7(1):54, 1-6. Nature Publishing Group
Spinal Cord Series and Cases, 7
Spinal Cord Ser Cases
Study design: Sub-study of a randomized controlled trial. Objectives: To examine if hybrid cycling (cycling with the legs via electrical stimulation combined with voluntary handcycling) compared to handcycling leads to different systemic vascular ada