Zobrazeno 51 - 60
of 18 630
pro vyhledávání: ''
Autor:
Xin Shu, Ni Chen, Michael A. Hill, Qian Gao, Mao Luo, Luochen Zhu, Jianbo Wu, Jiaqi Wu, Liqun Wang, Ziqian Feng, Zuoqin Du, Yi Li
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Adipose tissue serves as an essential endocrine regulator in glucose homeostasis and is involved in the progression of obesity and type 2 diabetes mellitus (T2DM), at least in part, through the induction of a chronic inflammatory state. Adipose tissu
Autor:
Yiyue Zhang, Zhibin Huang, Wenqing Zhang, Ping Meng, Yan Zhao, Jing Li, Jiakui Chen, Mei Wu, Zilong Wen, Jin Xu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Hematopoietic stem cells (HSCs) possess the potential for self-renew and the capacity, throughout life, to differentiate into all blood cell lineages. Yet, the mechanistic basis for HSC development remains largely unknown. In this study, we character
Autor:
Lindsey M. Ludwig, David B. Banks, Anika T. Thomas-Toth, Katrina M. Hawley, Megan E. McNerney, Joel D. Leverson, James L. LaBelle, Bruce R. Blazar
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
BH3 mimetics are increasingly used as anti-cancer therapeutics either alone or in conjunction with other chemotherapies. However, mounting evidence has also demonstrated that BH3 mimetics modulate varied amounts of apoptotic signaling in healthy immu
Autor:
Matías Pibuel, Daniela Poodts, Silvia E. Hajos, Paula G. Franco, Yamila Azul Molinari, Silvina Lompardía, Mariángeles Díaz
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Death Discovery
Cell Death Discovery
The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery, 7(1):293. Nature Publishing Group
Cell Death Discovery
Cell Death Discovery, 7(1):293. Nature Publishing Group
Cell Death Discovery
Liver cancer is one of the most common and lethal types of oncological disease in the world, with limited treatment options. New treatment modalities are desperately needed, but their development is hampered by a lack of insight into the underlying m
Autor:
Xiaoguo Zheng, C. Yan Cheng, Xinzhi Zhao, Yunbo Qiao, Fei Sun, Yuchuan Zhou, Hanshu Wang, Zhenhua Li, Guishuan Wang
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-22 (2021)
Cell Discovery
Cell Discovery
Paternal life experiences impact offspring health via germline, and epigenetic inheritance provides a potential mechanism. However, global reprogramming during offspring embryogenesis and gametogenesis represents the largest hurdle to conceptualize i
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Duplication of MECP2 (methyl-CpG-binding protein 2) gene causes a serious neurological and developmental disorder called MECP2 duplication syndrome (MDS), which is usually found in males. A previous clinical study reported that MDS patient has precoc
Autor:
Jun Zhang, Li Hou, Xiao Yu, Huan Zhang, Qingqing Zhang, Fei Ling, Yunliang Sun, Jinyi Meng, He Huang, Jaceline Gislaine Pires Sanches, Bo Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and metastasis is the major cause of the high mortality of HCC. In this study, we identified that AnnexinA7 (ANXA7) and Sorcin (SRI) are overexpressed and interacting protein
Autor:
Sung-Chul Lim, Joohyun Ryu, In-Youb Chang, Jeeho Kim, Ho Jin You, Jung-Hee Lee, Young Jin Jeon
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Oncogenic Ras mutations are frequently observed in solid tumor cells and are present in pancreatic cancer, colorectal cancer (CRC), and lung cancer (LC) [1, 2]. Mutational activation of K-Ras in these tissues is sufficient to initiate neoplasia in mi
Autor:
Huey-Jiun Ko, Chung-Hwan Chen, Chihuei Wang, Po-Hsu Chou, Cheng-Jung Ho, Tzu-Shao Liao, Xiang-Ren Zheng, Li-Ting Wang, Ru-Wei Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Doxorubicin-induced apoptosis only occurred