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Autor:
Jee Hye Choi, Sangmyung Rhee, Sung Haeng Lee, Simon Lovestone, Lee Sael, Ah Ra Do, Jungsoo Gim, Suparna Ghosh, Sanghun Lee, Kyu Yeong Choi, SangYun Kim, Seula Keum, Juhong Park, Lindsay A. Farrer, Jang Jae Lee, Andrew J. Saykin, Gyun Jee Song, Byeong C. Kim, Kwangsik Nho, Jun Young Park, Eunae Kim, Kun Ho Lee, Immanuel Dhanasingh, Seung Hwan Moon, Hoowon Kim, Kyungtaek Park, Donghe Li, Jinyeon Jo, Tamil Iniyan Gunasekaran, Dong Soo Lee, Sungho Won, Sarang Kang, Gyungah Jun
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Established genetic risk factors for Alzheimer’s disease (AD) account for only a portion of AD heritability. The aim of this study was to identify novel associations between genetic variants and AD-specific brain atrophy. We conducted genome-wide a
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Autor:
Kong-Peng Lam, Joey Kay Hui Teo, Susana Soo-Yeon Kim, Hsueh Lee Lim, Alison P. Lee, Andy Hee-Meng Tan, Jia Tong Loh, Koon-Guan Lee
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved in immun
Autor:
Ming Shen, Haiting Dai, Runming Wang, Lixin Xie, Suhong Zhang, Hanyu Wu, Ye Hu, Wenya Li, Yiming Xing
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Transmembrane protein (TMEM) is a family of protein that spans cytoplasmic membranes and allows cell–cell and cell–environment communication. Dysregulation of TMEMs has been observed in multiple cancers. However, little is known about TMEM116 in
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Advanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly malignant tumor without viable treatment option, highlighting the urgent need to seek novel therapeutic targets. Arylsulfatase D (ARSD), localized at Xp22.3, is
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Ubiquitination displays a crucial role in various biological functions, such as protein degradation, signal transduction, and cellular homeostasis. Accumulating evidence has indicated that ubiquitination is essential in cancer progression. Ubiquitin-
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Aberrant microRNA (miR) expression plays an important role in pathogenesis of different types of cancers, including B-cell lymphoid malignancies and in the development of chemo-sensitivity or -resistance in chronic lymphocytic leukemia (CLL) as well
Autor:
Ruoyue Tan, Pan Huang, Yutao Wang, Yundong Zhang, Jianbing Hou, Yudong Liu, Hongjuan Cui, Dakun Pei
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
RAN binding protein 10 (RANBP10), a ubiquitously expressed and evolutionarily conserved protein, as a RAN-GTP exchange factor (GEF) to regulate several factors involved in cellular progression. Previous studies showed that RANBP10 was overexpressed i
Autor:
Yafang Wei, Youzhou Tang, Yeyi Yang, Jishi Liu, Yongchao Sun, Quan Zhuang, Xinyu Li, Zhihao Gao, Xianming Zhang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Previous studies demonstrated that cGAS pathway is related to the inflammation amplification in a variety of autoimmune diseases. Lysine acetyltransferase family (KATs) can regulate the nuclear transcription or cytoplasmic activation of cGAS through