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Autor:
Xiao Feng Zhu, Zhuo-Yan Zhong, Kaiming Zhang, Xiao-Jun Qian, Yu-Hong Chen, Yan Yu, Shun Li, Xue-Lian Xu, Dong Yang, Li-Huan Zhou, Hai-Liang Zhang, Gong-Kan Feng, Rong Deng, Jun-Dong Li, Xuan Li, Yun-Tian Li, Yun Huang, Xiao-Dan Peng, Zhi-Ling Li, Xiang Huang, Jia Mai
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial networ
Autor:
Jing Jing Zhao, Yulong Han, Hao Chen, Tong Xiang, De-Sheng Weng, Jian-Chuan Xia, Feng-Ze Sun, Qijing Wang, Yan Tang, Ruiqing Peng, Yuanyuan Chen, Yuan-Yuan Liu, Jia He, Han Li, Yongqiang Li, Chaopin Yang, J. Yang, Mengjia Song, Yue Huang, Qiu-Zhong Pan, Tingting Gong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
Most patients with hepatocellular carcinoma (HCC) are in the middle or advanced stage at the time of diagnosis, and the therapeutic effect is limited. Therefore, this study aimed to verify whether deoxythymidylate kinase (DTYMK) increased in HCC and
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
The role of Golgi/endosome-localized clathrin adapters in the maintenance of steady-state cell surface epidermal growth factor receptor (EGFR) is not well known. Here, we show that EGFR associates preferentially with both AP-1 and GGA2 in vitro. AP-1
Autor:
Jee Hye Choi, Sangmyung Rhee, Sung Haeng Lee, Simon Lovestone, Lee Sael, Ah Ra Do, Jungsoo Gim, Suparna Ghosh, Sanghun Lee, Kyu Yeong Choi, SangYun Kim, Seula Keum, Juhong Park, Lindsay A. Farrer, Jang Jae Lee, Andrew J. Saykin, Gyun Jee Song, Byeong C. Kim, Kwangsik Nho, Jun Young Park, Eunae Kim, Kun Ho Lee, Immanuel Dhanasingh, Seung Hwan Moon, Hoowon Kim, Kyungtaek Park, Donghe Li, Jinyeon Jo, Tamil Iniyan Gunasekaran, Dong Soo Lee, Sungho Won, Sarang Kang, Gyungah Jun
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Established genetic risk factors for Alzheimer’s disease (AD) account for only a portion of AD heritability. The aim of this study was to identify novel associations between genetic variants and AD-specific brain atrophy. We conducted genome-wide a
Autor:
Rui Zhang, Lu Liu, Lu Lu, Yan Geng, Wenwei Zhu, Zhifei Lin, Lun-Xiu Qin, Ming Lu, Minghao Fan, Hu-Liang Jia, Jinhong Chen, Ju-Bo Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis. However, little is known abo
Autor:
Xiaofeng Zou, Quanliang Liu, Guancheng Xiao, Kaiyang Qiu, Yuting Wu, Junrong Zou, Guoxi Zhang, Gengqing Wu, Rihai Xiao, Hui Xu, Biao Qian, Yunfeng Liao, Yanmin Li, Tianpeng Xie, Jinglin Shi, Zhihua He, Yuanhu Yuan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinom
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Mounting studies have substantiated that abrogating autophagy contributes to cardiac hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported to support autophagy and inhibit CH. However, the upstream regulation mechanism behind the regulation of SIRT1
Autor:
Cheng-Feng Qin, Yongchun Li, Fei Yuan, Jiankai Liu, Jianguo Zhao, Shujun Liu, Aihua Zheng, Junfeng Hao, Chaoyue Zhao, Hongyue Li, Yong-Qiang Deng, Dan Wen, Dong Li, Yuhang Zhang, Hongde Xu, Shuguang Duo, Jiandong Liu, Yong Wu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Autor:
Ce Dou, Ruoxian Deng, Melissa Zarr, Xu Cao, Zengwu Shao, Gehua Zhen, Lieping Chen, Linda N. Liu, Yang Dan, Yusheng Li, Ruomei Wang, Qiaoyue Guo
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Bone Research
Bone Research
Osteoporosis (OP) is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures. Pharmaceutical therapies that promote anabolic bone formation in OP patients and OP-induce