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Autor:
Sadaf Soloukey, Andreas Rowald, Claudia Kathe, Ivan Furfaro, Philipp Schonle, Valentina Paggi, Quentin Barraud, Stéphanie P. Lacour, Jimmy Ravier, Qiuting Huang, Kyungjin Kim, Thomas H. Hutson, Ileana O. Jelescu, Antoine Philippides, Noaf Salah Ali Alwahab, Chris I. De Zeeuw, Daniel Huber, Frédéric Michoud, Leonie Asboth, Noe Brun, Jerome Gandar, Grégoire Courtine
Publikováno v:
Nature Biotechnology, 40 (2)
Nature Biotechnology, 40(2), 198-208. Nature Publishing Group
Nature Biotechnology, 40, 198-208. Nature Publishing Group
Nature Biotechnology, 40(2), 198-208. Nature Publishing Group
Nature Biotechnology, 40, 198-208. Nature Publishing Group
Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultr
Autor:
Jing Zhao, Han Xiao, Ping Liang, Ning Jiang, Li Zhang, Shuyue Zheng, Hui Gan, Xuan Zhai, Hui Chen, Lu Wang
Publikováno v:
Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1807-1818 (2021)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The NLRC4 inflammasome, a member of the nucleotide-binding and oligomerization domain-like receptor (NLR) family, amplifies inflammation by facilitating the processing of caspase-1, interleukin (IL)–1β, and IL-18. We explored whether NLRC4 knockdo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Autor:
Aleksandra Sobiborowicz, Dominika Nowis, Paweł Jabłoński, Agnieszka Borowiec, Anna A Marusiak, Alicja Mazan, Monika K. Prelowska, Dawid Mehlich, Adam Gorczyński, Ewa Iżycka-Świeszewska, Michał Łomiak, Łukasz M. Szewczyk, Dagmara Dymerska, Anna Mehlich
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential
Autor:
Yuan-Ting Kuo, Kai-Ti Lin, Yi-Hsiang Wang, Wen-Hung Kuo, Chia-Yi Shen, Lu-Hai Wang, Wen-Ching Wang, Yu-Ling Hsu, Sheng-Chieh Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast ca
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Autor:
Shenshen Wu, Xiaobo Li, Xinwei Zhang, Haitao Zhu, Qingtao Meng, Michael Aschner, Michela Relucenti, Bin Li, Jun Yun, Rui Chen, Jie Xu, Hongbao Yang, Giuseppe Familiari, Hao Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients f
Autor:
Lin Zhang, Xiao-Bo Wang, Yong Liu, Zhi-Bin Yu, Xiang Zhou, Jie Yang, Bo Jiao, Yanqi Liu, Ru-Zhou Zhao, Shuai Jiang, Zhao Xingcheng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Rapid adaptation to a hypoxic environment is an unanswered question that we are committed to exploring. At present, there is no suitable strategy to achieve rapid hypoxic adaptation. Here, we demonstrate that fasting preconditioning for 72 h reduces
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Melanoma originates from melanin-producing cells called melanocytes. Melanoma poses a great risk because of its rapid ability to spread and invade new organs. Cellular metastasis involves alteration in the gene expression profile and their transforma
Autor:
Zheng Li, Zhe Xuan, Jialun Lv, Guangli Sun, Hao Xu, Diancai Zhang, Hao Fan, Zekuan Xu, Jiacheng Cao, Linjun Wang, Yiwen Xia, Sen Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Gastric cancer (GC) ranks the third among global cancer-related mortality, especially in East Asia. Angiogenesis plays an important role in promoting tumor progression, and clinical trials have demonstrated that anti-angiogenesis therapy is effective
Autor:
Fei Zhang, Lei Wang, Yanglin Yan, Jian Zhang, Tao Wang, Hong Luo, Wuxun Peng, Zhihong Xie, Wentao Dong
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Novel therapies for the treatment of early steroid-induced osteonecrosis of the femoral head (SONFH) are urgently needed in orthopedics. Transplantation of bone marrow mesenchymal stem cells (BMSCs) provides new strategies for treating this condition