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Autor:
Alissa Visram, Francis K. Buadi, Wilson I. Gonsalves, S. Vincent Rajkumar, Angela Dispenzieri, Martha Q. Lacy, Rahma Warsame, Morie A. Gertz, Eli Muchtar, Shaji Kumar, Robert A. Kyle, Nelson Leung, David Dingli, Linda B. Baughn, Suzanne R. Hayman, Prashant Kapoor, Taxiarchis Kourelis
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 11, Pp 1-8 (2021)
Blood Cancer Journal
Blood Cancer Journal
The Mayo-2018 smoldering multiple myeloma (SMM) risk score is used routinely in the clinical setting but has only been validated at diagnosis. In SMM patients, the progression risk decreases over time. However, the utility of applying risk stratifica
Autor:
Mark-David Levin, Paula F. Ypma, Sonja Zweegman, Monique C. Minnema, Pieter Sonneveld, Esther G. M. de Waal, Eduardus F. M. Posthuma, Mirian Brink, Kaz Groen, Niels W.C.J. van de Donk, Ellen van der Spek, Avinash G Dinmohamed, Annemiek Broijl
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 11, Pp 1-7 (2021)
Blood Cancer Journal, 11(11):178. Nature Publishing Group
Blood Cancer Journal
Brink, M, Groen, K, Sonneveld, P, Minnema, M C, Broijl, A, Dinmohamed, A G, van der Spek, E, Levin, M D, Ypma, P F, de Waal, E, Posthuma, E F M W, Zweegman, S & van de Donk, N W C J 2021, ' Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands : a population-based study ', Blood cancer journal, vol. 11, no. 11, 178 . https://doi.org/10.1038/s41408-021-00571-8
Blood cancer journal, 11(11):178. Nature Publishing Group
Blood Cancer Journal, 11(11):178. Nature Publishing Group
Blood Cancer Journal
Brink, M, Groen, K, Sonneveld, P, Minnema, M C, Broijl, A, Dinmohamed, A G, van der Spek, E, Levin, M D, Ypma, P F, de Waal, E, Posthuma, E F M W, Zweegman, S & van de Donk, N W C J 2021, ' Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands : a population-based study ', Blood cancer journal, vol. 11, no. 11, 178 . https://doi.org/10.1038/s41408-021-00571-8
Blood cancer journal, 11(11):178. Nature Publishing Group
Identification of risk factors for early mortality (EM) in multiple myeloma (MM) patients may contribute to different therapeutic approaches in patients at risk for EM. This population-based study aimed to assess trends in EM and risk factors for EM
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it ur
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-7 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
This study (ORIENT-4) aimed to assess the efficacy and safety of sintilimab, a humanized anti-PD-1 antibody, in patients with relapsed/refractory extranodal NK/T cell lymphoma (r/r ENKTL). ORIENT-4 is a multicenter, single-arm, phase 2 clinical trial
Autor:
Xiangkai Zhang, Shuli Liu, Jiong Deng, Yong Han, Liu Liu, Yang Wang, Shengming Xu, Zhiyuan Zhang, Weimin Ye
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor with poor clinical outcomes due to recurrence, metastasis, and treatment resistance. Cancer stem cells (CSCs), a small population among tumor cells, are proposed to be respons
Autor:
Naval Daver, Jing Ning, Guillermo Garcia-Manero, Tapan M. Kadia, Hagop M. Kantarjian, Nicholas J. Short, Wei Qiao, Daewoo Pak, Jabra Zarka, Farhad Ravandi, Marina Konopleva, Fadi Haddad, Zhenya Tang, Keyur P. Patel, Ghayas C. Issa, Elias Jabbour, Gautam Borthakur, Courtney D. DiNardo, Branko Cuglievan, Koji Sasaki, Michael Andreeff
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Acute myeloid leukemia (AML) with rearrangement of the lysine methyltransferase 2a gene (KMT2Ar) has adverse outcomes. However, reports on the prognostic impact of various translocations causing KMT2Ar are conflicting. Less is known about associated
Autor:
Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu, Yang Wu, Da-Xuan Tang, Fu-Chun Zhang, Meng Qiu, Qi Hua, Jing-Yu He, Jun Li, Bai Du, Ting-Hai Du, Lin-Lin Niu, Xue-Jun Jiang, Bo Cui, Jiang-Bin Chen, Yang-Gan Wang, Hai-Rong Wang, Qin Yu, Jing He, Yi-Lin Mao, Xiao-Fang Bin, Yue Deng, Yu-Dan Tian, Qing-Hua Han, Da-Jin Liu, Li-Qin Duan, Ming-Jun Zhao, Cui-Ying Zhang, Hai-Ying Dai, Ze-Hua Li, Ying Xiao, You-Zhi Hu, Xiao-Yu Huang, Kun Xing, Xin Jiang, Chao-Feng Liu, Jing An, Feng-Chun Li, Tao Tao, Jin-Fa Jiang, Ying Yang, Yao-Rong Dong, Lei Zhang, Guang Fu, Ying Li, Shu-Wei Huang, Li-Ping Dou, Lan-Jun Sun, Ying-Qiang Zhao, Jie Li, Yun Xia, Fan Liu, Wen-Jin He, Jian-Cong Tan, Yang Lin, Ya-Bin Zhou, Jian-Fei Yang, Guo-Qing Ma, Hui-Jun Chen, He-Ping Liu, Zong-Wu Liu, Jian-Xiong Liu, Xiao-Jia Luo, Xiao-Hong Bin, Ya-Nan Yu, Hai-Xia Dang, Bing Li, Fei Teng, Wang-Min Qiao, Xiao-Long Zhu, Bing-Wei Chen, Qi-Guang Chen, Chun-Ti Shen, Yong-Yan Wang, Yun-Dai Chen, Zhong Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-10 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart disease. Here, in an adaptive, 31-cente
Autor:
Eli Muchtar, Prashant Kapoor, Lisa Hwa, David Dingli, Taxiarchis Kourelis, Amie Fonder, Morie A. Gertz, Matthew Ho, Shaji Kumar, Suzanne R. Hayman, Saurabh Zanwar, Francis K. Baudi, Nelson Leung, Robert A. Kyle, Miriam Hobbs, Martha Q. Lacy, Angela Dispenzieri, Rahma Warsame, S. Vincent Rajkumar
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
The optimal duration of lenalidomide maintenance post-autologous stem cell transplant (ASCT) in Multiple Myeloma (MM), and choice of therapy at relapse post-maintenance, need further evaluation. This retrospective study assessed outcomes of patients
Autor:
Betsy LaPlant, Thomas M. Habermann, Ivana N. Micallef, Luis F. Porrata, Rebecca L. King, Yucai Wang, Stephen M. Ansell, William R. Macon, Patrick B. Johnston, David J. Inwards, Thomas E. Witzig, Sanjal Desai, Grzegorz S. Nowakowski
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-7 (2021)
Blood Cancer Journal
Blood Cancer Journal
Diffuse large B-cell lymphoma (DLBCL), either concurrent with or transformed from follicular lymphoma (FL) is often excluded from clinical trials. Lenalidomide has response rates of 45% in relapsed transformed DLBCL. Herein we present an analysis of