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Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-7 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
This study (ORIENT-4) aimed to assess the efficacy and safety of sintilimab, a humanized anti-PD-1 antibody, in patients with relapsed/refractory extranodal NK/T cell lymphoma (r/r ENKTL). ORIENT-4 is a multicenter, single-arm, phase 2 clinical trial
Autor:
Pavel Jindra, Riita Niittyvuopio, Hervé Tilly, Jakob Passweg, Gesine Bug, Dietrich W. Beelen, Klaus Hirschbühl, Bruno Lioure, Mohamad Mohty, Arnon Nagler, Jan J. Cornelissen, Sebastian Giebel, Hélène Labussière-Wallet, Myriam Labopin, Mohamed Houhou, C. Schmid, Gerald Wulf, Ludovic Gabellier
Publikováno v:
Bone Marrow Transplantation, 56(5), 1190-1199. Nature Publishing Group
Second- and third-generation tyrosine kinase inhibitors (TKI) play an important role in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, data on feasibility and efficacy of using these drugs for pers
Autor:
Corinne Ammon Zufferey, Dominik Grathwohl, Cathriona Monnard, Katherine Macé, Yasaman Shahkhalili, Julien Sauser, Maurice Beaumont
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-11 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background/Objectives Different infant formulas, varying in protein type and quantity, are available for infants who are not breastfed or are partially breastfed. Postprandial insulinemic and glycemic responses to intact vs partially hydrolyzed prote
Autor:
Jacalyn Rosenblatt, Diane Warren, Kelly Masone, Dena Grayson, Sascha A. Tuchman, Kathleen Colson, Paul G. Richardson, Jacob P. Laubach, Robert A. Redd, Constantine S. Mitsiades
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-8 (2021)
Blood Cancer Journal
Blood Cancer Journal
Additional therapeutic options are needed for relapsed and refractory multiple myeloma (RRMM). We present data from a phase 1b, open-label, dose-escalation study (NCT01965353) of 20 patients with RRMM (median age: 63 years [range: 50–77]) and a med
Autor:
Xing Hu, Xin Liu, Weibo Zhu, Liangquan Geng, Li Zhou, Jin Xu, Juan Tong, Yongsheng Han, Xinhui Zhang, Lei Xue, Xiaoyu Zhu, Xingbing Wang, Na Zhao, Baolin Tang, Lei Zhang, Changcheng Zheng, Shanglong Feng, Zimin Sun, Huilan Liu, Xiaoyan Cai
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 1, Pp 1-5 (2021)
Blood Cancer Journal
Blood Cancer Journal
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Low circulating levels of long chain omega-3 polyunsaturated fatty acids (LC omega-3 PUFA) have been linked to major depressive disorder (MDD) and preterm birth (PTB), and prenatal depression associates with PTB. We therefore hypothesized that low Om
Autor:
Sat Byul Seo, Hyun-Kyung Cho
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
We aimed to classify early normal-tension glaucoma (NTG) and glaucoma suspect (GS) using Bruch’s membrane opening-minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer (RNFL), and the color classification of RNFL based on a deep-lear
Autor:
Alejandro Balsa, Ana M. Ortiz, Laura Nuño, Cristina Regueiro, Ana Martínez-Feito, Diana Peiteado, Ana Triguero-Martinez, Isidoro González-Álvaro, Alejandro Villalba, Holger Bang, L Rodriguez-Martinez, Antonio Gonzalez
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Scientific Reports
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Scientific Reports
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
The presence of rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) autoantibodies contributes to the current rheumatoid arthritis (RA) classification criteria. These criteria involve stratification on antibody levels, which limits
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Exhaustion of Hepatitis C Virus (HCV)-specific T cells and abnormal B cell function is a hallmark of chronic HCV infection. Direct-acting antiviral (DAA) therapies are effective in achieving sustained virologic response (SVR), however, whether succes
Autor:
Simina Crisan, Alciona Sasu, A.L. Pop-Moldovan, Lucian Petrescu, Alexandru Fica Mircea Onel, Mirela Cleopatra Tomescu, Aurora Bordejevic, Oliviana Geavlete, Alexandru Nicolae Mischie, Nelu-Mihai Trofenciuc
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Although doxorubicin (Dox) is an effective antitumor antibiotic in the anthracycline class, it often induces the undesirable side effect of cardiomyopathy leading to congestive heart failure, which limits its clinical use. The primary goal of this st