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Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Developmental disorders characterized by small body size have been linked to CDK5RAP2 loss-of-function mutations, but the mechanisms underlying which remain obscure. Here, we demonstrate that knocking down CDK5RAP2 in human fibroblasts triggers prema
Autor:
Salvatore Sciacchitano, Arianna Di Napoli, Benjamin Terrier, Carlo Capalbo, Frauke Goeman, Francesca De Nicola, Michela D'Ascanio, Alberto Ricci, Christian Napoli, Simona di Martino, Giulia Piaggio, Agostino Tafuri, Andrea Sacconi, Maurizio Fanciulli, Luisa de Latouliere, Darragh Duffy, Luciano De Biase, Andrea Negro, Valentina Salvati, Claudia De Vitis, Carla Mottini, Rita Mancini, Francesca Paolini, Giovanni Blandino, Paolo Anibaldi, Paolo Marchetti, Gennaro Ciliberto
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death and Disease, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death and Disease, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death & Disease
Clinical outcomes of COVID-19 patients are worsened by the presence of co-morbidities, especially cancer leading to elevated mortality rates. SARS-CoV-2 infection is known to alter immune system homeostasis. Whether cancer patients developing COVID-1
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-11 (2021)
International Journal of Oral Science
International Journal of Oral Science
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradiation. Inc
Autor:
Ben Liu, Yufan Ying, Xueyou Ma, Xiao Wang, Xiangyi Zheng, Weiyu Wang, Liping Xie, Bo Xie, Haiyun Xie, Jiangfeng Li, Jian Wu, Jiajie Fang, Shiming Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (I
Autor:
Shengnan Yang, Ziyang Hong, Qinglin Tan, Jinke Zhuge, Qiang Zuo, Xuxian Zhong, Jing Guo, Qiong Deng, Jiaqi Liao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Trastuzumab resistance negatively influences the clinical efficacy of the therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and the underlying mechanisms remain elusive. Exploring the mechanisms and finding eff
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
MicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquiti
Autor:
Guo-Dong Zhu, Jiewen Zhang, Feng-Min Shao, Guo-Long Liu, Hong-Mei Zheng, Jing Yu, Yan Chen, Shi Ou-Yang, Mei-Lan Lin, Zheng-Yu Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
Glioblastomas (GBM) is the most common primary malignant brain tumor, and radiotherapy plays a critical role in its therapeutic management. Unfortunately, the development of radioresistance is universal. Here, we identified calcium-regulated heat-sta
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck sq
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Conventional chemotherapy is still of great utility in oncology and rationally constructing combinations with it remains a top priority. Drug-induced mitochondrial apoptotic priming, measured by dynamic BH3 profiling (DBP), has been shown in multiple
Autor:
Jiewei Liu, Zihan Qu, Jiang Chen, Lu Li, Xianzhe Yu, Lingling Zhu, Qinghua Zhou, Hong-e Zhang, Li Wang
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
Several immune checkpoint blockades (ICBs) capable of overcoming the immunosuppressive roles of the tumor immune microenvironment have been approved by the US Food and Drug Administration as front-line treatments of various tumor types. However, due