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Autor:
Bartok, Osnat, Pataskar, Abhijeet, Nagel, Remco, Laos, Maarja, Goldfarb, Eden, Hayoun, Deborah, Levy, Ronen, Körner, Pierre-Rene, Kreuger, Inger Z M, Champagne, Julien, Zaal, Esther A, Bleijerveld, Onno B, Huang, Xinyao, Kenski, Juliana, Wargo, Jennifer, Brandis, Alexander, Levin, Yishai, Mizrahi, Orel, Alon, Michal, Lebon, Sacha, Yang, Weiwen, Nielsen, Morten M, Stern-Ginossar, Noam, Altelaar, Maarten, Berkers, Celia R, Geiger, Tamar, Peeper, Daniel S, Olweus, Johanna, Samuels, Yardena, Agami, Reuven, Dep Scheikunde, Veterinaire biochemie, Sub Biomol.Mass Spect. and Proteomics, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., dB&C FR-RMSC RMSC, Biomolecular Mass Spectrometry and Proteomics
Publikováno v:
Nature, 590(7845). Nature Research
Nature, 590(7845), 332-337. Nature Publishing Group
Nature
Nature, 590(7845), 332-337. Nature Publishing Group
Nature
Extensive tumour inflammation, which is reflected by high levels of infiltrating T cells and interferon-γ (IFNγ) signalling, improves the response of patients with melanoma to checkpoint immunotherapy1,2. Many tumours, however, escape by activating
Autor:
Akira Fukuya, Yasuo Takahashi, Masahiro Hirakawa, Yasushi Sato, Hiroshi Miyamoto, Kyoko Hamaguchi, Tetsuji Takayama, Naoki Muguruma, Tamotsu Sagawa, Koshi Fujikawa, Koichi Okamoto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The primary tumour location is an important prognostic factor for previously untreated metastatic colorectal cancer (mCRC). However, the predictive efficacies of primary tumour location, early tumour shrinkage (ETS), and depth of response (DpR) on mC
Autor:
Xiaofei Zheng, Shiwen Zhang, Guomin Ou, Peng Deng, Yunshu Wu, Cun-Yu Wang, Qiwen Li, Yuchen Guo, Y. Chen, Quan Yuan, Yuting Liu, Xingying Qi, Weiqing Liu, Yuan Wang, Liyan Zhou, Weimin Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in th
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Herpes simplex virus type-1 (HSV-1), one of the most widely spread human viruses in the Herpesviridae family, causes herpes labialis (cold sores) and keratitis (inflammation of the cornea). Conventional treatment for HSV-1 infection includes pharmace
Autor:
Florian Zeman, Ingo Einspieler, Andreas G. Schreyer, Niklas Verloh, Jan Schaible, Philipp Wiggermann, Lukas Philipp Beyer, Reto Bale, Christian Stroszczynski, Lukas Lürken
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
In this study, we compare the primary efficacy of computed tomography-navigated stereotactic guidance to that of manual guidance for percutaneous microwave ablation of liver malignancies. In total, 221 patients (140, 17, and 64 with hepatocellular ca
Autor:
Anna Ianza, Monica Ramello, Enrico Mini, Giandomenico Roviello, Alberto D'Angelo, Martina Catalano, Raffaele Conca, Lorenzo Dreoni, Roberto Petrioli, Stefania Nobili, Silvia Gasperoni, Michele Aieta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Neutropenia is a common side effect associated with nab-paclitaxel gemcitabine (Nab-Gem) therapy. We retrospectively investigated the association between neutropenia induced by first-line Nab-Gem and survival in metastatic pancreatic carcinoma patien
Autor:
Patrick J. Rochette, Anne-Sophie Gary
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Ultraviolet radiation (UVR) is a major environmental genotoxic agent. In skin, it can lead to the formation of mutagenic DNA damage. Several mechanisms are in place to prevent the conversion of these DNA damage into skin cancer-driver mutations. An i
Autor:
Alka Bhatia, Amanjit Bal, Neeraj Khatri, Shivani Jaiswal, Nayudu Nallabelli, Vivek Singh Malik, Deep Maheshwari, Rajesh Kumar, Neenu Jacob, Naresh Sachdeva, Savita Verma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Type-1 diabetes (T1D) is an autoimmune disease caused by progressive loss of insulin-producing beta cells in the pancreas. Butyrate is a commensal microbial-derived metabolite, implicated in intestinal homeostasis and immune regulation. Here, we inve
Autor:
Jun-Hyeok Kang, Wen-Fang Cheng, Yoo-Young Lee, Yen-Ling Lai, Hyun Soo Kim, Kuan-Ting Kuo, Yu-Li Chen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Low-grade ovarian serous carcinoma (LGSOC) has clinical features different from high-grade serous ovarian carcinoma (HGSOC) accounting for the majority of epithelial ovarian cancer. Because of its rarity, previous studies have only focused on the hig
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) i