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Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading to tumor progression and metastasis. Extracellular vesicles (EVs) are n
Autor:
Tong Shen, Youlutuziayi Rixiati, Ling-Dong Cai, Jian-Ming Li, Jing-Lin Liu, Chu-Yi Wang, Yuan-Yuan Zhao, Shi Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-18 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The mechanisms and key factors involved in tumor environments for lung metastasis of CRC are still unclear. Here, using clinical samples from lung metastases of CRC patients, we found that intestinal immune network for IgA production was significantl
Autor:
Xin Wang, Wenqiang Liu, Dan Liao, Kuntai Jiang, Tiebang Kang, Ruhua Zhang, Jingjing Li, Zhiliang Cao, Miao Li, Sui Jianhua, Cuiling Zeng, Yi Xin Zeng, Jingxuan Wang, Li Zhong
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-16 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PY
Autor:
Yanping Yu, Xiaofang Zhang, Jun Liu, Xinhui Zhao, Ye Wu, Haiming Liu, Jipeng Li, Jianyong Sun, Yihuan Qiao, Angang Yang, Ke Wang, Rui Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Fork-head box protein M1 (FoxM1) is a transcriptional factor which plays critical roles in cancer development and progression. However, the general regulatory mechanism of FoxM1 is still limited. STMN1 is a microtubule-binding protein which can inhib
Autor:
Hong Yang, Jing Xu, Jinhai Tang, Qing Li, Runqiu Jiang, Xuehao Wang, Liyong Pu, Jiannan Qiu, Yong Ni, Yuanchang Hu, Liren Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possibl
Autor:
Bei Wang, Dao Wen Wang, Ingrid Fleming, Jiong Hu, Chen Chen, Lingli Dong, Lujin Wu, Jing Chen, Zheng Wen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-30 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by ph
Autor:
Xiaofei Zhou, Shao Cong Sun
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Cancer immunotherapy has become an attractive approach of cancer treatment with tremendous success in treating various advanced malignancies. The development and clinical application of immune checkpoint inhibitors represent one of the most extraordi
Autor:
Bojiang Chen, Jing Ren, Weimin Li, Zhoufeng Wang, Guoya Zheng, Peng Cheng, Yu Zhang, Sisi Dai, Xuping Chen, Wenxin Luo, Ping Zhou, Xiaodong Yang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-10 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Primary pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare non-small cell lung cancer (NSCLC) subtype. Clinical features have been described in our previous report, but molecular characteristics remain unclear. Herein, pLELC genomic feature
Autor:
Nissar A. Wani, Parvaiz Yousuf, Ajaz A. Bhat, Surinder K. Batra, Shyam S. Chauhan, Mohammad Haris, Davide Bedognetti, Mushtaq A. Siddiqi, Muzafar A. Macha, Arshi Rizwan, Wael El-Rifai, Michael P. Frenneaux
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. D
Autor:
Xiangjian Luo, Min Tang, Jianmin Hu, Luqing Zhao, Xinfang Yu, Lin Zhao, Weihua Liao, Longlong Xie, Yueshuo Li, Feng Shi, Ya Cao, Ann M. Bode
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-33 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Epstein–Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Moreover, EBV plays an etiological and pat