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Autor:
Ben Liu, Yufan Ying, Xueyou Ma, Xiao Wang, Xiangyi Zheng, Weiyu Wang, Liping Xie, Bo Xie, Haiyun Xie, Jiangfeng Li, Jian Wu, Jiajie Fang, Shiming Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (I
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
MicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquiti
Autor:
Jing Ji, Yue Li, Bin Liu, Xiaotian Huang, Mei Ji, Zhao Zhao, Wei Liu, Zhe Li, Kaige Wang, Penglin Xu, Jia Shi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Heterogeneous nuclear ribonucleoprotein L (hnRNPL) is a type of RNA binding protein that highly expressed in a variety of tumors and plays a vital role in tumor progression. However, its post-translational regulation through ubiquitin-mediated proteo
Autor:
Zheng-Yang Wu, Zhanguo Sun, Xinwei Han, Peng Li Zhou, Miao Xu, Wenguang Zhang, Qinhui Zhang, Jianzhuang Ren
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Growing evidence has indicated that circular RNAs (circRNAs) play a pivotal role as functional RNAs in diverse cancers. However, most circRNAs involved in esophageal squamous cell carcinoma (ESCC) remain undefined, and the underlying molecular mechan
Autor:
Anna Trauzold, Anna Willms, Michelle Poelker, Alshaimaa Adawy, Steven Singh, Jan Frederik Debus, Tim Krichel, J. Fritsch, Torsten Hartwig, Silvia von Karstedt, Heiner Schäfer, Henning Walczak, Hella Schupp
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
TNF-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2) can induce apoptosis in cancer cells upon crosslinking by TRAIL. However, TRAIL-R2 is highly expressed by many cancers suggesting pro-tumor functions. Indeed, TRAIL/TRAIL-R2 also act
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Accumulating evidence has suggested that long noncoding RNAs (lncRNAs) exert crucial modulation roles in the biological behaviors of multiple malignancies. Nonetheless, the specific function of lncRNA LINC00284 in papillary thyroid cancer (PTC) remai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Growing evidence indicates that circular RNAs (circRNAs) are closely involved in tumorigenesis, but the association between circRNAs and pancreatic ductal adenocarcinoma (PDAC) is far from clear. Here, we focused on the functional investigation of ci
Autor:
Ming Hsien Chan, Michael Hsiao, Hsing Fang Tsai, Yu Chan Chang, Chien Hsiu Li, Chih Jen Yang, Yu Wen Tseng, Jean Chiou
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Cell Death Discovery
Cell Death Discovery
Phosphoglycerate kinase (PGK) is involved in glycolytic and various metabolic events. Dysfunction of PGK may induce metabolic reprogramming and the Warburg effect. In this study, we demonstrated that PGK1, but not PGK2, may play a key role in tumorig
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association between dysregulated WWP1 expression and cl
Autor:
Simona D'Aguanno, Elisabetta Valentini, Rino Ragno, Marta Di Martile, Donatella Del Bufalo, Stefania Garzoli, Manuela Sabatino
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Essential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma. In this study, we investigated the antitumor activity of a panel