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Autor:
Bartok, Osnat, Pataskar, Abhijeet, Nagel, Remco, Laos, Maarja, Goldfarb, Eden, Hayoun, Deborah, Levy, Ronen, Körner, Pierre-Rene, Kreuger, Inger Z M, Champagne, Julien, Zaal, Esther A, Bleijerveld, Onno B, Huang, Xinyao, Kenski, Juliana, Wargo, Jennifer, Brandis, Alexander, Levin, Yishai, Mizrahi, Orel, Alon, Michal, Lebon, Sacha, Yang, Weiwen, Nielsen, Morten M, Stern-Ginossar, Noam, Altelaar, Maarten, Berkers, Celia R, Geiger, Tamar, Peeper, Daniel S, Olweus, Johanna, Samuels, Yardena, Agami, Reuven, Dep Scheikunde, Veterinaire biochemie, Sub Biomol.Mass Spect. and Proteomics, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., dB&C FR-RMSC RMSC, Biomolecular Mass Spectrometry and Proteomics
Publikováno v:
Nature, 590(7845). Nature Research
Nature, 590(7845), 332-337. Nature Publishing Group
Nature
Nature, 590(7845), 332-337. Nature Publishing Group
Nature
Extensive tumour inflammation, which is reflected by high levels of infiltrating T cells and interferon-γ (IFNγ) signalling, improves the response of patients with melanoma to checkpoint immunotherapy1,2. Many tumours, however, escape by activating
Autor:
Akira Fukuya, Yasuo Takahashi, Masahiro Hirakawa, Yasushi Sato, Hiroshi Miyamoto, Kyoko Hamaguchi, Tetsuji Takayama, Naoki Muguruma, Tamotsu Sagawa, Koshi Fujikawa, Koichi Okamoto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The primary tumour location is an important prognostic factor for previously untreated metastatic colorectal cancer (mCRC). However, the predictive efficacies of primary tumour location, early tumour shrinkage (ETS), and depth of response (DpR) on mC
Autor:
Florian Zeman, Ingo Einspieler, Andreas G. Schreyer, Niklas Verloh, Jan Schaible, Philipp Wiggermann, Lukas Philipp Beyer, Reto Bale, Christian Stroszczynski, Lukas Lürken
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
In this study, we compare the primary efficacy of computed tomography-navigated stereotactic guidance to that of manual guidance for percutaneous microwave ablation of liver malignancies. In total, 221 patients (140, 17, and 64 with hepatocellular ca
Autor:
Sophia Maund, Russell Bainer, Thomas Januario, Subhra Chaudhuri, Tharu M. Fernando, Robert Piskol, Huong Trinh, Robert L. Yauch, Ethan Sokol, Zora Modrusan, Sally E. Trabucco, Marc Kschonsak, Qing Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Genomic studies performed in cancer patients and tumor-derived cell lines have identified a high frequency of alterations in components of the mammalian switch/sucrose non-fermentable (mSWI/SNF or BAF) chromatin remodeling complex, including its core
Autor:
Anna Ianza, Monica Ramello, Enrico Mini, Giandomenico Roviello, Alberto D'Angelo, Martina Catalano, Raffaele Conca, Lorenzo Dreoni, Roberto Petrioli, Stefania Nobili, Silvia Gasperoni, Michele Aieta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Neutropenia is a common side effect associated with nab-paclitaxel gemcitabine (Nab-Gem) therapy. We retrospectively investigated the association between neutropenia induced by first-line Nab-Gem and survival in metastatic pancreatic carcinoma patien
Autor:
Patrick J. Rochette, Anne-Sophie Gary
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Ultraviolet radiation (UVR) is a major environmental genotoxic agent. In skin, it can lead to the formation of mutagenic DNA damage. Several mechanisms are in place to prevent the conversion of these DNA damage into skin cancer-driver mutations. An i
Autor:
Jun-Hyeok Kang, Wen-Fang Cheng, Yoo-Young Lee, Yen-Ling Lai, Hyun Soo Kim, Kuan-Ting Kuo, Yu-Li Chen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Low-grade ovarian serous carcinoma (LGSOC) has clinical features different from high-grade serous ovarian carcinoma (HGSOC) accounting for the majority of epithelial ovarian cancer. Because of its rarity, previous studies have only focused on the hig
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) i
Autor:
Jianing Chen, Jing Zhou, Xi Huang, Sheng-Cai Lin, Yiran Shi, Hao Zhao, Changchuan Xie, Hui-Hui Hu, Shu-Yong Lin, Erwei Song, Dong-Tai Liu, Lanfen Chen, Lintao Song, Jing Ye, Ying Yang, Zhihua Liu, Terytty Yang Li, Zhi-Zhong Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary f
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Deep learning analysis of images and text unfolds new horizons in medicine. However, analysis of transcriptomic data, the cause of biological and pathological changes, is hampered by structural complexity distinctive from images and text. Here we con