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Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-11 (2021)
International Journal of Oral Science
International Journal of Oral Science
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradiation. Inc
Autor:
Shengnan Yang, Ziyang Hong, Qinglin Tan, Jinke Zhuge, Qiang Zuo, Xuxian Zhong, Jing Guo, Qiong Deng, Jiaqi Liao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Trastuzumab resistance negatively influences the clinical efficacy of the therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and the underlying mechanisms remain elusive. Exploring the mechanisms and finding eff
Autor:
Karen L. Talia, Britta Weigelt, Yoshiki Mikami, Esther Oliva, Cathleen Matrai, Pier Selenica, W. Glenn McCluggage, Emanuela Veras, Yaser R. Hussein, Regina G. H. Beets-Tan, Takako Kiyokawa, Barbara Alemar, Kay J. Park, Rajmohan Murali
Publikováno v:
Modern Pathology, 34(6), 1213-1225. Nature Publishing Group
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Gastric-type cervical adenocarcinoma (GCA) is an aggressive type of endocervical adenocarcinoma characterized by mucinous morphology, gastric-type mucin, lack of association with human papillomavirus (HPV) and resistance to chemo/radiotherapy. We cha
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association between dysregulated WWP1 expression and cl
Autor:
Yan Zheng, Haoting Sun, Mo Chen, Yuan-Yuan Sheng, Lun-Xiu Qin, Qiongzhu Dong, Xudong Ren, Qin Luo, Bei-Yuan Hu, Yan Geng, Tiantian Zou, Xiao-Mei Gao, Kai-Li Zhang, Chaoqun Wang, Lu-Yu Yang, Shican Yan, Yan Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely unknown. Exosomes released by tumor cells have been proved to be effective cell-to-cell signal m
Autor:
Dewei Jiang, Wenli Liu, Aiham Qdaisat, Lu Li, Haixia Wang, Sai Ching J. Yeung, Wenjing Liu, Runxiang Yang, Rong Liu, Zhongmei Zhou, Ceshi Chen, Jiao Wu, Sicheng Liu, Chuanyu Yang, Zhuo Cheng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Weight loss and cachexia are common problems in colorectal cancer patients; thus, parenteral and enteral nutrition support play important roles in cancer care. However, the impact of nonessential amino acid components of nutritional intake on cancer
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates prac
Autor:
Sang-Hee Cho, Rashedunnabi Akanda, Kyung-Hwa Lee, Eun Gene Sun, Jun-Eul Hwang, Hyun-Jeong Shim, Ji-Na Choi, Ik-Joo Chung, Woo Kyun Bae, Mi-Ra Park
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Galectin 3-binding protein (LGALS3BP, also known as 90K) is a multifunctional glycoprotein involved in immunity and cancer. However, its precise role in colon inflammation and tumorigenesis remains unclear. Here, we showed that Lgals3bp−/− mice w
Autor:
Yicheng Chen, Liya Wang, Huan Wang, Zeyi Lu, Hao Zhang, Liqun Xia, Mingchao Wang, Gonghui Li, Qiming Zheng, Lifeng Ding
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Nerves are important pathological elements of the microenvironment of tumors, including those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent studies have associated perineural invasion with tumor progression and
Autor:
Wei Hwa Lee, Shao-Cheng Liu, Chi Tai Yeh, Tung Nien Hsu, Chun Shu Lin, Ting Yi Huang, Ming Shou Hsieh, Chih Ming Huang, Yang Che Wu, Chin Sheng Huang, Mao Suan Huang
Publikováno v:
Oncogenesis, Vol 10, Iss 2, Pp 1-18 (2021)
Oncogenesis
Oncogenesis
Locally advanced oral squamous cell carcinoma (OSCC) requires multimodal therapy, including surgery and concurrent chemoradiotherapy (CCRT). CCRT-resistant and recurrent cancer has a poor prognosis. We investigated the effects of Bruton’s tyrosine